COVID-19 vaccine discussion

34 minutes ago, kevwun said:

They all had their antibody levels tested.  The higher the number the better.

My rheumatologist indicated that the antibody testing was a very inexact science and not a good predictor of efficacy. 

4 minutes ago, Nonbryan said:

Are those chart antibody numbers taken right after they received the 2nd shot?  Or are they #s from the recent past?

Mine from yesterday 

So I've been on Tigerdroppings a bit lately as we play them on 9/4.  They are losing their marbles over LSU's decision to mandate vaccines or negative tests to attend a game at Tiger Stadium.  

1 minute ago, Sbbruin said:

My rheumatologist indicated that the antibody testing was a very inexact science and not a good predictor of efficacy. 

My GP said the same thing. But it is a good indicator the vaccine is still on the job.

there’s also a theory that the reason for breakthrough infections of Delta is simply due to the enormous viral load overwhelming antibodies, and that the reason most of those breakthroughs are not serious is that T-cells and other components kick in and defeat it after the initial overwhelming. 
 

A corollary theory to that is that higher total antibodies might mean less chance of breakthrough.  
 

Just theories though

22 minutes ago, Brisketexan said:

Which re-raises my question.  There is an annual "variant" of the flu every year.  That is, the flu vaccine is different from one year to the next in terms of the exact virus it targets, but there's not a whole FDA approval process for each year's version.  So....how does that work, and could the COVID vaccine follow a similar path -- that is, it can be adjusted for new variants without having to do the whole long-term new approval process?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947948/

Annual update of seasonal influenza vaccines

To maintain effectiveness, the composition of seasonal influenza vaccines must be reviewed and updated periodically to include the most current HA antigens expressed by circulating influenza wild‐type viruses. This is a complex, lengthy process that requires extensive collaboration among influenza manufacturers, vaccine regulators, and global public health laboratories. The process begins with the recommendations, coordinated globally by the World Health Organization (WHO), for the virus strains to be included in the vaccine.⁴ The WHO recommendations for the Northern Hemisphere, which are based on recent global surveillance data available each February, provide a guide to national public health authorities and vaccine manufacturers for the development and production of influenza vaccines for the following winter influenza season. However, as noted in the WHO recommendations, it is the responsibility of each national regulatory authority to approve the composition and formulation of the vaccines used in that country. Each year, soon after the WHO Northern Hemisphere vaccine recommendations are finalized, the FDA convenes its Vaccines and Related Biological Products Advisory Committee (VRBPAC), typically in late February or early March, to recommend the virus strains that should be included in FDA‐licensed influenza vaccines for the next winter influenza season in the United States.

In the United States, licensed influenza vaccine manufacturers must submit a supplement to their license for review and obtain FDA approval before the updated version of the influenza vaccine containing new virus antigens can be distributed. Such supplements to inactivated and recombinant protein seasonal influenza vaccines do not require additional clinical data specific for the new strain. Supplements to the licensed live influenza virus vaccine require a study in approximately 300 adults prior to approval of the new strain to verify adequate attenuation. Manufacturing of influenza vaccine takes place over an approximately 6‐month time frame beginning prior to the VRBPAC strain selection and lasting until mid‐summer, when the trivalent or quadrivalent vaccine is formulated, filled, and distributed. The manufacturing timelines are tight and the process of producing influenza vaccine involves many sequential steps and overlapping processes. Even with technologic advancements, each of these steps and processes still requires time to complete, and there is limited flexibility in the timelines for manufacturing. A schematic diagram of the process and key steps is shown in Figure Figure11.

 

 

Personally, I think it is risky with an mRNA vaccine. The new vaccine target could cause unforeseen problems like myocarditis and death. But, I do not like how the FDA handles diseases like COVID. If you wanted to select for better COVID strains, you would target a portion of a single variable gene in COVID. If you want to eradicate the disease, you would target multiple genes so the virus would have to mutate in multiple spots to remain viable. The FDA process makes targeting multiple genes difficult, however.

1 hour ago, fluff said:

	Vaccine	Last Shot
Fluff	Moderna	March	1154
TexEx15	Moderna	February	994
KaiserSoze	Moderna	January	978
JesusSweatDuck Wife	Moderna	April	1290
Babysdaddy	Pfizer	March	714
Liquor and Poker	Pfizer	February	587

 

Thought I would see if there are any trends here...Let me know if I missed anyone and I will add them.

Moderna/March/2115

1 hour ago, fluff said:

	Vaccine	Last Shot
Fluff	Moderna	March	1154
TexEx15	Moderna	February	994
KaiserSoze	Moderna	January	978
JesusSweatDuck Wife	Moderna	April	1290
Babysdaddy	Pfizer	March	714
Liquor and Poker	Pfizer	February	587

 

Thought I would see if there are any trends here...Let me know if I missed anyone and I will add them.

Ha!  I was doing the same thing but plotting it, then got sidetracked. Here's the data that includes conViNCEd and L&P's update on his own numbers (which seriously skews the Pfizer data and makes it impossible to plot a trendline).

 

 

DP

 

 

 

Edited August 24, 2021 by utee94

43 minutes ago, Pato del Muerto said:

I wonder if a higher than average antibody count would hint at a successfully fought off exposure/infection that triggered the war machine. 

 

As part of this study they also test you for SARS-CoV-2 antibodies... I had none (which aligns with me not having been sick). 

DP

Edited August 24, 2021 by utee94

2 minutes ago, utee94 said:

Ha!  I was doing the same thing but plotting it, then got sidetracked. Here's the data that includes conViNCEd and L&P's update on his own numbers (which seriously skews the Pfizer data and makes it impossible to plot a trendline).

 

 

Always an outlier

8 minutes ago, utee94 said:

Ha!  I was doing the same thing but plotting it, then got sidetracked. Here's the data that includes conViNCEd and L&P's update on his own numbers (which seriously skews the Pfizer data and makes it impossible to plot a trendline).

 

 

Awesome, I will let you take it from here!!  Good stuff!

1 hour ago, StruggleBus said:

 

Most companies can't pay an invoice within thirty days. A 95 day timeline is incredible. 

I'm just looking at the original timeline the vaccines were developed:

Jan 11th - Genetic sequence of virus is released publicly

Feb 24th - Moderna sends vaccine to NIH for testing

March 16th - First volunteer gets the shot

That is 65 days. I know there's probably some manufacturing challenges that would need to be addressed, but it also seems like you wouldn't need to have as much time waiting on testing for a fully approved vaccine. 

That chart needs to have time relativity.  My levels are 5 months post 2nd shot

Just had blood drawn for the antibody test (4.5 months after 2nd Pfizer shot). Will report back in a few days

1 hour ago, StruggleBus said:

Most companies can't pay an invoice within thirty days. A 95 day timeline is incredible. 

It is, but then FDA/CDC/etc. are all prioritizing anything related to that, and throwing money at the pharmas to get it done.

And covid-19 has been studied extensively at this point.  

 

1 hour ago, Sbbruin said:

So I've been on Tigerdroppings a bit lately as we play them on 9/4.  They are losing their marbles over LSU's decision to mandate vaccines or negative tests to attend a game at Tiger Stadium.  

Maybe they saw it as the 2021 version of a massive chicken pox party.

10 minutes ago, babysdaddy said:

That chart needs to have time relativity.  My levels are 5 months post 2nd shot

All levels are "current."  The point is to note that the numbers are likely to be higher, the more recent the second shot.  It should decline, the further away in the past the second shot was.  And the data bears that out, aside from L&P's crazy outlier.

 

 

20 minutes ago, babysdaddy said:

That chart needs to have time relativity

So I've been on Tigerdroppings a bit lately as we play them on 9/4.  They are losing their marbles over LSU's decision to mandate vaccines or negative tests to attend a game at Tiger Stadium.  

But how hard is it really to fake a vaccine card?

And who is really going to check them when being bum rushed by a billion mouth breathers at the gate?

Also, anyone laminating or putting their card in any sort of case? Seems like carrying that thing around and whipping it out on the reg will do it in quickly.

I have an electronic vax record from APH I keep on my phone.

12 minutes ago, tbone_ said:

Also, anyone laminating or putting their card in any sort of case? Seems like carrying that thing around and whipping it out on the reg will do it in quickly.

I made a two-sided color photocopy of mine, which I laminated and keep in my wallet.  The original stays at home with my (other) passport.

Yeah, sounds like it depends on the jurisdiction, but I have an app on phone that when opened pulls up a QR code which reveals my vaccine dates and locations.

14 minutes ago, tbone_ said:

Also, anyone laminating or putting their card in any sort of case? Seems like carrying that thing around and whipping it out on the reg will do it in quickly.

take a picture of it and save on your phone. that's what I was told and have done.

 

3 hours ago, TexEx15 said:

Just got mine back.  Second shot (Moderna) was beginning of February.  994.  

How long did it take from blood draw to your getting the results?

9 minutes ago, dcbc said:

How long did it take from blood draw to your getting the results?

24 hours or so

10 minutes ago, dcbc said:

How long did it take from blood draw to your getting the results?

Blood draw yesterday around lunch and results this morning.  If you have not already done so register your account on the CPL website.  Text response is a simple positive or negative.  Details including antibody number are on the web.

2 hours ago, conVINCEd said:

Not part of this study, but I had my 2nd Moderna shot in late April, caught a mild case of COVID in early June and was 1163 3 weeks ago.

That sounds like a solid strategy...

 

35 minutes ago, JesusSweatDuck said:

 

God fucking damn. I don't want to agree with that arkie piece of shit

Edited August 24, 2021 by StruggleBus

3 minutes ago, StruggleBus said:

 

God fucking damn. I don't want to agree with that arkie piece of shit

I'll set aside decades of hate for a global pandemic

I'll set aside decades of hate for a global pandemic

Works for me. Doesn’t make him not total failure at running a football team.

2 minutes ago, JesusSweatDuck said:

I'll set aside decades of hate for a global pandemic

A drunk, broken down clock is right twice a day.

Got my antibody test back. Pfizer. Second shot on 01/19/2021. Third shot 08/17/2021. Tested on 08/23/2021.

Out of Range. >2,500. Outlier because of booster. But I will be able to track it over the next 6 months. No prior COVID infection.

6 minutes ago, dcbc said:

Got my antibody test back. Pfizer. Second shot on 01/19/2021. Third shot 08/17/2021. Tested on 08/23/2021.

Out of Range. >2,500. Outlier because of booster. But I will be able to track it over the next 6 months. No prior COVID infection.

Lambda says hi....

26 minutes ago, dcbc said:

Got my antibody test back. Pfizer. Second shot on 01/19/2021. Third shot 08/17/2021. Tested on 08/23/2021.

Out of Range. >2,500. Outlier because of booster. But I will be able to track it over the next 6 months. No prior COVID infection.

Nice. Think I will go this weekend and get my 1st Pfizer. Wink wink. 
Seriously though do pharmacies have both and they ask you or do you have to research where your previous is being administered?

4 hours ago, StruggleBus said:

Most companies can't pay an invoice within thirty days. A 95 day timeline is incredible. 

I've spent most of my career training our customers that they either pay now or fuck off.  We're not a bank.  I suspect the companies that still insist on paying you when they feel like it are run by mouth breathing aggies with horse paste in their veins.  Get with the times or die on a ventilator.  We've managed to drag a few of the big boys into the modern era, to the chagrin of their accounting departments.

31 minutes ago, dcbc said:

Got my antibody test back. Pfizer. Second shot on 01/19/2021. Third shot 08/17/2021. Tested on 08/23/2021.

Out of Range. >2,500. Outlier because of booster. But I will be able to track it over the next 6 months. No prior COVID infection.

So the third shot doesn’t have the two-week lagtime before it starts working?

21 minutes ago, Shaddie said:

Nice. Think I will go this weekend and get my 1st Pfizer. Wink wink. 
Seriously though do pharmacies have both and they ask you or do you have to research where your previous is being administered?

I finally convinced a family member to get the vaccine. They used CVS and the options were J&J or Moderna. Pfizer wasn't an option for them

This was north DFW fyi

Just now, Zepol87 said:

I finally convinced a family member to get the vaccine. They used CVS and the options were J&J or Moderna. Pfizer wasn't an option for them

This was north DFW fyi

Thanks

51 minutes ago, dcbc said:

Out of Range. >2,500.

2 hours ago, DDD Dad said:

I made a two-sided color photocopy of mine, which I laminated and keep in my wallet.  The original stays at home with my (other) passport.

I just have them scan my arm

Meanwhile, in the Ozarks...

2 minutes ago, Sawbonz said:

I just have them scan my arm

Problem with that is did guv website designers do the code or did private industry do the code. 
 

6 minutes ago, Sawbonz said:

I just have them scan my arm

Except the scanner will stick to your arm from all the magnets in your arm.

5 minutes ago, SizzleChest said:

Meanwhile, in the Ozarks...

Hail merry.

Thank God! 
 

Just got a text from wife saying my Florida sister got her 1st vax today. 
Me and my other sis have been working on her for awhile about it. Last week I texted “God made the scientists who made the vax” 

I was never clear if it was religious or trump views for her reasons but I don’t care. Will keep slightly hounding her so hopefully she gets 2nd. 
 

By the way I am agnostic so me saying that is just to appease the religious 

What is crazy about my sister, is she has had bad asthma since birth. 
She and her husband were stationed in Spain about 1985 and she had bad attack and was hospitalized.  Me and my other sis went to Houston to get passports cause she might not make cause she was intubated. 
 

You would think somebody who has been there would do anything not to be there again.  
We need to absolutely kill this right wing bullshit that this is leftist or against freedumbs.