Triads and inversions are a great way to understand chords and their relationships to scales on the guitar, and it’s an easy skip from their to jazz arpeggios adding the 7ths.
As for alternate tunings, yeah, your fretboard knowledge may diminish, but it might make it easier to do some things. Like slide with open G tuning. I mostly stick to standard and drop D tuning where most of my fretboard knowledge stays intact.
But, I use other more disruptive alternate tunings a lot for fingerpicked acoustic pieces, where you can get some really interesting things going with your left hand that would be impossible in standard tuning. Meaning, the intervals being played with an arpeggiated finger picked arp would be impossible to fret with your left hand in standard tuning. In this type of music, I’m not looking to play scale runs. I’m thinking very little about scales at all and more about arpeggiated chords and chord melody.