One elephant in the room in the future is the quality gap between the Big 10 and SEC. The Big 10 just isn't that deep with elite teams. 2/3rds of the league are Big 12/ACC schools with nicer, richer parents. The SEC is about 25% schools that fit that bill, by comparison.
Another thing is people keep asking "what's the end game?" like there's a tight cabal that has a specific outcome in mind and is just slow rolling the whole thing. I think it is FAR more chaotic and random than that, with decisions being made on what's profitable in that moment, with no centralized goal whatsoever. Over the last 20 years there have been many guarantees in realignment that didn't pan out. The 4 x 16 superconferences with the champions in the playoffs made up of pods, with the conferences being the Big 10, SEC, Pac 12, and ACC as the Big 12 died was the guarantee. Now the Pac 12 is dead, and the Big 12 is as well positioned as the ACC if not better. The current guarantee du jour is that the Big 10 and SEC will break away into somewhere between 32-48 schools into an NFL Lite.
I have little doubt there will be future brand consolidation (the big ACC brands going to the SEC/Big 10) but I don't think that straight AFC/NFC model unfolds like that. I think there's some kind of split in D1 with the current G5 in one group and the current P4 in one group. The Big 10 and SEC will have the bulk of the money and power, but whatever playoff exists will have some token access to the third conference (if we even call them that at that point) that shakes out when the ACC left-behinds that still care about sports merge with the Big 12 into a third conference. I believe that ultimately walling off access to the roughly 60 schools not in a top 48 would lead to less interest in that level of the sport, and therefore less revenue created.
Basically, I think it continues on the same path it's kind of on already, just with some more deck reshuffling and brand consolidation.