I'm surprised this caliber argument persists so well with time. Since scopes have both evolved and become more readily available to allow a quick adjustment of dope, almost any caliber can be made into a shooter at practical hunting ranges. This has been said above, but practice with your own and knowing the rifle, the load, and the conditions around you all matter more than the caliber (imho).
I have a lot of friends that spend a lot of money (in my accounting) on multiple factory rifles...I always recommend selling them and going custom build with one caliber that you can then work towards achieving excellence with it. You don't even have to go all in...just get a local smith to throw on a good barrel, bed the action, maybe work the trigger a bit, and thread the fucking barrel. Get a high quality scope (2nd hand is fine). Purchase the equipment and learn to load (or join a friend to help get you started....or test out 4-5 different custom loads from suppliers and see what works best for your setup, as an alternatively to loading yourself). Suppress it if within your means.
For CenTex, I love my little 300BO Rem 7 build...it's quiet, light weight / convenient, insanely accurate with tsx handloads, and I trust my little NF 2.5-10x24 to dial it in at any range within 300 yds (limiting to that because I haven't practiced with it further). It eats venison and piggies all day long.