Bump. I was on an immunotherapy drug (Opdivo) the first half of '23, and it quite literally ripped me a new asshole, or at least plenty of holes in my colon. Had to stop the Opdivo, but the uclerative colitis, which had always been held in check with Remicade, has been fucking me up to no end for months and months. Tried all manner of steroids with little relief. So after chasing various solutions, the next step is to drop the remicade (which I've been taking for almost 2 decades and which works wonders on my ankylosing spondylitis) in favor of Rinvoq, which treats both AS and UC. But it does lead to clotting, and having been diagnosed with having had a stroke sometime in June, there is a concern there. God I'm a fucking mess. Even though it appears the cancer is in remission, the fallout has been brutal. And although it's only January, I think I have the shart thread all locked up for '24. In no way do I document all my misgivings, but suffice it to say numerous underwear have been tossed, at work and otherwise. FML.