Went to Charleston a couple of weeks ago. Stayed at The Dewberry. Booked through AmEx and got some nice perks. Free breakfast which was delicious. The people there were great - setup a tour of an oyster farm and used one of the hotel's Volvos to get there. Great rooftop bar as well.
Raw 167 was tremendous. Pricey but worth it. They're known for their pastrami-ed swordfish sandwich. Get it. After reading this thread your expectations could get very lofty. Hope they don't ruin your experience.
We ate at HUSK and FIG. Loved both. Rabbit potpie at HUSK was fantastic and had schnitzel at FIG - weird choice I know, but very good.
R Kitchen was a very cool dinner. 3 young chefs in an old house. Two seatings per night. Five courses - no menu. Would recommend.
Gin Joint was my favorite bar.
Many hot young ladies walking around - they kinda ignored my old, fat ass. Same as in Texas.
Have fun.