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triplehorn

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Everything posted by triplehorn

  1. Following up on the Yale collab above, notice the attention Dr. Iwasaki pays to "inflammasomes" : Inflammasomes are non-membrane bound cytosolic protein complexes that appear to be associated with a variation of programmed cell death called pyroptosis. Pyroptosis is a highly inflammatory form of cell death often associated with intracellular pathogens - like viruses and certain bacteria. Here's a graphic of inflammosomal activation (hook'em UT Southwestern). Note the release of IL-18 and IL-1b. The pinwheel stucture is the inflammasome (originally characterized around 2002). Also note the association with cytosolic lysosomes (membrane bound organelle): So maybe it would be helpful, if not extremely helpful, if we could find a way to attenuate the role of Covid associated inflammasome activation and cell death to reduce the cascade resulting in tissue and multiple organ damage observed with Covid. You had to know where I was going with this lol. Naturally I wondered if there's a possibility that HCQ fits into this somewhere. HCQ is generally thought of as inhibiting replication of Covid virus via a Zinc mechanism that inhibits viral RNA dependent RNA polymerase which has been clearly demonstrated in vitro. But we also know HCQ has anti-inflammatory properties. It's why it's used every day to treat Lupus and Rheumatoid Arthritis. Every freaking day. So where in the vast array of immune function does the anti-inflammatory mechanism of HCQ fit ? Turns out in this study Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation. Also from this research on rheumatologic mechanisms of action of Chloroquine and Hydoxychloroquine: "These drugs interfere with lysosomal activity and autophagy, interact with membrane stability and alter signalling pathways and transcriptional activity, which can result in inhibition of cytokine production and modulation of certain co-stimulatory molecules." Look again at the picture above. Lysosomal activity works through the cathepsin and NLRP3 pathway to activate inflammosomes resulting in a highly inflammatory response with IL-18 and IL-1b. So it appears the anti-inflammatory mechanism of CQ/HCQ has a direct and intimate tie to inhibiting a key pathway for multi-organ pathogenesis with Covid-19 that has just now been uncovered as crucial by the Yale collaboration I posted above. Would this have potentially beneficial protective effects when applied pre-cytokine storm in Covid-19 infection? Sure appears that way, and is consistent with clinical observations.
  2. This intra-Yale collab just yielded some amazing insights with potential immediate impact on clinical decision making: Longitudinal analyses reveal immunological misfiring in severe COVID-19 this entire twitter thread is an ultra-dense cliffs notes of the above article by one of the PI's an worth close consideration: excerpted tweet: The last tweet stands out ---> one key feature of severe disease formation is low T cell number. Should make you go straight to thinking about the role of Vit D here. Quick reference points to Vit D levels playing a role in T cell numbers and modulating T cell function, and may induce many different anti-inflammatory functions. Read that correctly, anti-inflammatory, or the opposite of having an immune response run amok, ie what we've come to associate with with severe disease formation in covid. See general discussion: The Link. They then progressed to identifying 3 clusters of patients based on 4 immune signatures leading to the ability to form new targets for early diagnostic recognition that could also better inform specific types of early intervention revealed by those immune signatures.
  3. This is damn horrific - study shows almost 8 of 10 infected with covid have persisting cardiac abnormalities irrespective of health status or severity of illness. JAMA: Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19) - 78% of Covid-19 patients had abnormal cardiac markers “independent of preexisting conditions, severity [illness]" -Cardiac function remains impaired in most recovered patients, even middle aged people. -Lymphocytes can invade the heart, causing edema and fibrosis. Cardiac fibrosis. -Persisting impaired cardiac function nearly as likely in outpatient cases as hospital cases.
  4. First, I'm not propping up this doc. Never heard of her until yesterday and watching her lose it in that outside interview made me cringe. But I don't think she's lying. In listening to her rant, I did pick up that she said what sounded like sick Covid patients are coming to her from the greater Houston area outside of Katy. Traveling less than 30 miles to see a physician for specialized treatment is pretty ordinary. So i wouldn't call her a liar based off of a comparison to absolute caseload of Katy proper. She's brought a national spotlight on herself, so I expect the digging to proceed at full steam ahead. We'll know soon enough if she's a fraud or just a truthful well intentioned doctor who still has some cultural beliefs that carry over from her life being raised in Nigeria. A lot of physicians have different religious beliefs, some consider it magical thinking, but that doesn't influence their telling the truth and helping people to the best of their ability.
  5. I laughed. ☝️
  6. I'm well aware. Yale epidemiologist Harvey Risch MD PhD spoke to this in his recent article in Newsweek. Read the whole damn article. Don't expect to find anything about demon seed.
  7. I can't speak about applied human chorionic gonadotropin, but the safety of hcq has been long since established. To my knowledge a screening EKG is not even recommended in people who do not have known cardiac health or conduction problems. The drug is over the counter in a lot of countries around the world and the number of adverse events recorded during routine use of this medication is almost undetectable in relation to the tens of millions of doses taken over the last 60 years. Safety is not the issue at all. It's an irrational scare that materialized in the US out of thin air back in March. How and when during the course of illness it's use is best applied and to what quantifiable effect is still open for further clarification. But 65 studies and counting show positive results, particularly when used as early as possible and prophylactically.
  8. At least 350 around Katy, evidently, and reporting zero deaths. Somebody show she's lying or hiding even one patient dying of heart block and it's open and shut. I'll hang up and listen.
  9. Sad, not giddy. A 100% uniquely American shit show. Our numbers reflect it in so many ways. This Dr. Stella won't convince me about anything regarding Nigerian demon sperm, but I don't believe she's lying or deluded about no deaths occurring in 350+ patients she's treated in TX. Quite a lot of docs in TX prescribing this regimen and taking it themselves prophylactically. They're keeping it in office with their patients and choosing to not draw public attention to themselves, for reasons that are all way too obvious today. Most health care providers are accustomed to seeing people every day who are misinformed, have odd personal beliefs about medicine, and who routinely use bad judgement that negatively affects their prospects for health. It kind of pays the bills.
  10. Like the ukraine whistleblower thread that led to the third ever impeachment of a sitting president. I’ll give you that one jj lol
  11. I'll give this a few more days before starting a new thread on it, but I think it's lit. No blue thing on his account that's doubled in the last 24hr, but the detail is pinpoint. This is the kind of detail that lands you testifying under path on the Hill: I think he approached and already is cooperating with Congress (House). I also suspect he's done it with known others also coming forward to the House. In the second re-quoted tweet above he says "Others will tell the Libya and Russia side of the story." To whom? To Congress. What is the last and only not entirely corrupt body that can investigate and publicize evidence of this scale and kind? The House. If shit's coming down and you're in a position to get silenced from very high levels, what's the best place today to go to talk about stuff of this scale and kind? The House.
  12. Get DC Lafayette Square protesters on board:
  13. Here's a follow-up article to the large Israeli study demonstrating the importance of sufficient Vit D levels for fighting/limiting Covid infection: Vitamin D helps us fight Covid-19, major study finds - Israeli population-based study supports research showing that vitamin D supplements could help people avoid serious respiratory effects of Covid-19. While there is a lot of attention being paid to adaptive immunity, like antibody formation, it's important to keep in mind the essential role T cell mediated immunity plays in fighting novel infections. Adequate Vit D levels play a significant role in T cell mediated immune responses. I saw this graph depicting the relationship between Vit D blood levels and Covid infection: The pink column represents normal range (ie 30 ng/mL). For general purposes, taking 5000 IU of Vit D3 should get you at and above 30ng/mL within a few weeks if your levels are insufficient. There is a potential for Vit D toxicity at levels above ~150 ng/mL but that is very rare and seems to happen only with gross misadministration. Blood level testing is a good idea if folks are on prolonged high dose Vit D. So adding any med that can even slow the rate of viral replication might allow enough time for a decisive T cell mediated victory over Covid with adequate Vit D. Just a hunch, but I don't think the T Cell immunity just snaps into peak function with a loading dose of Vit D in those who are deficient. There's likely a sequence of cellular/molecular events that take days to weeks to correct to optimize the role for immune response.
  14. So much for the 'health care plan' Trump promised the other week.
  15. 'These are his people': inside the elite border patrol unit Trump sent to Portland Bortac, a quasi-militarised outfit equivalent to the Navy Seals, has been deployed in Iraq and Afghanistan Bortac? Navy Seals? Sounds like Erik Prince.
  16. If there's any meat at all, best case is tipping off the public now comes only well after relevant officials have been informed. And it very well may be that he's not the one that's going break news, just that he was involved and knows what's coming out.
  17. Assuming for the moment it's the real Gregg Smith, what would separate what he's indicated is going to drop from all those other investigations is that this is apparently about Prince's involvement in "fucking with the 2016 election" which he suggests contributed to tipping PA, MI, WI electoral outcomes. What's more important than Prince et al going to prison over past transgressions? That whatever they may have succeeded in doing in 2016 doesn't happen again. Whistleblowing has that very effect whether or not anyone gets punished. Waiting until this late also has a perhaps unintended effect of allowing less time for a well coordinated Plan B to get hatched. As Noel Casler described in the podcast I linked last page, so many people knew for years about Trump's insanity and unfitness and chose to not speak up in 2016 out of the belief it was impossible for him to ever actually get elected. In 2020, people are looking at stopping a repeat of the 2016 playbook as opposed to ratting people out so they go to jail.
  18. 🍿 Prince was a SEAL. This man is a Marine. opened his twitter account in June.
  19. Wow. They all fucking knew. This is something to watch when you've got a little free time. As NYC and LA insiders, they all offer a unique insight into the respective compartmentalized cultures that fed this Trump catastrophe. Also, surgical repair of his nose from cocaine addiction/Trump properties/Felix Sater/Russian mob/Jeffrey Epstein.
  20. Generic over-the-counter mucolytic medication, bromhexine, showing signs of efficacy against Covid in this RCT in Iran with collab from U of Arizona and U of Toronto: Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial Note these are patients who already have progressed to advanced illness/pneumonia. Mechanism of action thought to be inhibition of TMPRSS2 transmembrane protease involved in viral entry to cell via ACE2 receptor. This is a different path of inhibition than other agents under investigation, which means it potentially could be used in combination with other meds/mechs of action to achieve a greater therapeutic effect. Used safely in adults and children
  21. The protest area is concentrated now and there isn't any appreciable new property destruction. You can go 2 blocks in any direction and not know what's happening outside the Fed courthouse. Peaceful protesters are mostly policing themselves against outliers. The last 3 nights, the feds have been progressively spending less time making a show of force and tear gas seems to be getting used less. The fence in front of the courthouse is still not getting torn down or breached. Protesters were rattling the cage last night, making noise banging on it shouting "Feds go home" but not much more. Feds announced over bullhorn that they were about to start arresting people for fucking with the fence. The thousand or so protesters crammed up against the fence simply stopped banging on it and watched the faceless building. No feds came out to make arrests. Then it picked up again with less fence involvement. News coverage of this will move on while this cat and mouse game continues indefinitely until the shadow brutes leave.
  22. The shadow military rollout in DC Lafayette Sq got everyone's attention. AG Barr and Joint Chiefs of Staff Gen. Mark Milley walked alongside Trump in that violent photo-op. Gen. Milley immediately and publicly expressed regret for appearing there. So it got hobbled from the start. And now no one is buying the "city in anarchy at the hands of antifa" trope. I'm hearing people here not forgetting that police and criminal justice reform is necessary, but that this militaristic force turned on peaceful protesters with snatch and grab and use of blinding munitions is dangerous as hell. The protest will continue with or without the militarized feds there, but will die down to normal portland_prolonged _protest (could easily be months), and move on from national attention once the feds leave. I've been watching some live periscope protest feeds from downtown the last couple nights. It's looks like they're leaving the fence alone, not defacing it or trying to breach it or pull it down. No fire setting, but there are fireworks randomly getting set off. I've seen a couple times where it looked like fireworks got tossed over the fence but not clearly at a fed. All throwing shit over the fence should stop. The leaf blower brigade is organized and effective. If the perimeter fence is left alone and shit doesn't get hurled over the fence, this will stall and completely bleed out any benefit Trump imagines. And now ACLU already has a hold of a leg.
  23. Nightly crowd mostly in early 20's plus a city historically tolerant of prolonged encampment of protests (not to mention homeless) means over under on duration is 6 more months.
  24. Paper on observational study that shows how critical sufficient levels of Vit D are to weather Covid infection: Vitamin D Sufficiency Reduced Risk for Morbidity and Mortality in COVID-19 Patients
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