triplehorn

With this drug, they can go straight to human trials for Covid. The article says that even relatively high dose of this med is safe in people from studies looking at dengue viral infection (which isn't particularly effective vs dengue) "Importantly, recent reviews and meta-analysis indicate that high dose ivermectin has comparable safety as the standard low-dose treatment, although there is not enough evidence to make conclusions about the safety profile in pregnancy28,29. The critical next step in further evaluation for possible benefit in COVID-19 patients will be to examine a multiple addition dosing regimen that mimics the current approved usage of ivermectin in humans. " There's also this important consideration: "Ultimately, development of an effective anti-viral for SARS-CoV-2, if given to patients early in infection, could help to limit the viral load, prevent severe disease progression and limit person-person transmission." With Covid, a lot appears to hinge on early detection and intervention. If you wait until pneumonia has set in, the damage is done. That's one area where testing limitations in availability and rapid results are still biting us in he butt.

It's a medication that already has an established safety profile when people take it, hence the FDA approval for use to treat parasites. It's potent at knocking out this covid virus with a single dose in a petri dish. Need to see if that knockout dose translates into a safe effective dose in people. Hopefully you don't have to take x10 the normal parasite dose in order to kill the virus. But basic re-purposing an established med would be fast head start.

The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro •Ivermectin is an inhibitor of the COVID-19 causative virus (SARS-CoV-2) in vitro. •A single treatment able to effect ∼5000-fold reduction in virus at 48h in cell culture. •Ivermectin is FDA-approved for parasitic infections, and therefore has a potential for repurposing. •Ivermectin is widely available, due to its inclusion on the WHO model list of essential medicines.

A shift to paper ballots kills some of the most reliable voting machine driven voter suppression tactics. Can’t have that!

Exactly. All the way up to one week ago Thursday, it was Trump Easter sugar plum tales. The press is just getting rolled on this point, repeatedly. Even a blip of acceptance and response beginning in Feb and early March still makes a huge difference compared to where we are headed today.

Covid-19 Hitler-in-a-bunker edit coming soon.

now: "France reports 5,233 new cases of coronavirus and 1,120 additional deaths, including 532 people who died in nursing homes and were previously not counted" The uncounted nursing home deaths is something we've been hearing about in Italy as well. We also know a lot of people have simply died at home in Italy, but no idea on death counts there. I get the feeling a whole lot of Americans will succumb to this at home, in rural SE areas in particular, especially during the time all available hospitals are overrun. People will relegate themselves to survival on their own terms and it may or may not ever be adequately quantified. 14 days ago, the US was at 5k new cases per day, yet we're already at 1k deaths per day today. And today we're at about 30k new cases per day. So two weeks from now can only be substantially more grim.

Study: Published: 03 April 2020 Respiratory virus shedding in exhaled breath and efficacy of face masks cont. --> no surprise here, just that the viral transmission limiting effects of basic masks is increasingly evidence based. It's counter-intuitive, but masks actually are probably best at reducing the hand to face transmission of covid, which by some experts is thought to be the primary mode of infection. Basic paper surgical masks, (n95 not needed) reduce spray onto nearby surfaces that other people touch, more so than inhaling aerosol. Masks reduce infected people from touching their faces then touching surfaces that other people touch (door handles, hand rails, counter tops). Masks also prevent non-infected people from face touching after they've touched a contaminated surface. It's easy to see how everyone in the community benefits from masks to reduce risk of infection and spread whether you have it or not.

When people repeatedly get conflicting information, sense appeasement through falsehood telling, witness lack of leadership and wisdom, chaos is a lot more likely. When it's leveled and effectively communicated that the alternative is worse than the restrictions, people get it, and society itself becomes an enforcer. When that fails, start showing more films of people drowning to death from lungs full of blood and fluids, speechless and alone.

Again, within weeks of the outbreak, Taiwan mobilized national mask production capacity to 13 million masks per day. juice for the orange one > initiating maximum DPA generated mask capacity for Americans. There is no excuse. Negligent homicide doesn't adequately describe it..

Don't see how tests are going to be spent on the deceased when they're not available for the symptomatic. It's unconscionable, but this is a very real scenario that could lead to gross underreporting of mortality. So when someone like Rush is floating the idea that numbers of deaths are being exaggerated, that should set off a trip wire per the Trump related axiom "every accusation is a confession".

The failure to prepare and be prepared with material support is massive on multiple levels, but the inability to comprehend and accept basic measures in a timely manner to immediately reduce spread, like social distancing/SIP, is particularly unforgivable. January was China, but on March 3rd, Italy already had 2.5K cases with 500-1000 new cases per day. Yet even one week ago today, March 26th, Trump was still waxing about beautiful filled pews on Easter and messaging that the threat was not severe and would soon be over. A basic coordinated message at the national level during the first week of March about the reality of the threat and proven success of social distancing/SIP would have resulted in exponential reduction of the morbidity and mortality we're now getting because of Trump's failure. DeSantis and Kemp are peak enablers of Trump's market worshipping death cult.

It’s an open secret that the fed messaging to downplay the need for, or benefits of, public mask wearing is intended to reduce hoarding and diversion from health care. after its covid outbreak started, within a couple weeks Taiwan generated the national capacity to make 13 million masks per day. it’s an absolute failure that we don’t have a nationalized emergency manufacturing effort underway. In so many ways it feels too late, but every day we wait makes it so much worse than acting now.

The act of singing is like viral Napalm. that’s what lit up that whole church population in SoKo leading to thousands of cases. Scores of people side by side using their diaphragms to thrust through their larynxes at max frequency. If talking is a dripping faucet, singing is a crop irrigation gun.

This vid has been posted a couple time in threads and worth re-posting. This is a top SK medical official heading their national covid response. It's general consensus (and cultural norm) in SK/China/HK/Taiwan/Singapore that the public wearing masks significantly reduces risk of both being infected and spreading infection. We're not talking about 99% barriers for those repeatedly being exposed to known sick patients. You don't need 99%. He also references masks inhibiting unconscious face touching, which is arguably the most common way we get infected with covid. If covering your nose and mouth prevents automatic face touching until you wash your hands, practically anything is a whole lot better than nothing. He talks about their view on masks from starting at the 15 min mark. I'm comfortable wearing a neck gaiter/balaclava and wash it after I use it in public - about x1-2/week. It's crazy how reflexive face touching is. You don't even realize it until it's too late.

Finally, on April 1st. Now just need to threaten the use of flamethrowers in the streets like the Italians. and not use pseudo-lockdown strategy:

Given the primary asserted route being droplet touched by hand/hand to face, the statement about people unconsciously touching their face on average 20 times per hour really stands out. It’s about wearing a mask as a barrier to your own hands. In that case, no need for a standard surgical grade mask. We would just need the human equivalent of a dog cone for our hands. And hand washing. A single use between washes clean bandana/scarf would go a long way. Anything washable would help conserve. Spreading by sustained contact mostly among people who are together for 30 minutes or longer is probably also mostly by hand to face as well. When you are at home for instance you don’t wear a mask and are more likely to touch your face. It’s also a lot harder to keep every surface clean in your home compared to avoiding a door handle or elevator button. Quadruple that if there are kids in the house. Outside of home any place you spend 30 minutes or more with other people you’re likely to touch shared surfaces between cleaning with the likelihood of touching your face.

Plus they'll have some highly relevant hands on experience to pass on when they return.

make it through to the other side ...and for good measure

Need to start a Covid Sanctuary members thread

No Donald, that Large Blue Mountain Blix referenced isn’t your paunch (Donald peers down)

They have sanctions imposed and they're still better off than us ? Let that sink in.

Historical "Black mirror" The big difference between now and then is vaccine therapy. So not likely to be a factor long term.

I saw the one month (to death) number batted around a few pages back:

If we don't completely drop the hammer, it will take longer, but the numbers will still get really, really bad. R naught (R0) has to maintained at <1. 3/30 Imperial College study: