triplehorn

Yet this: "When are we going to be able to sit in a theater and watch our favorite performers up on stage again?" "I think it's going to be a combination of a vaccine that has been around for almost a year and good public-health measures," Fauci told Garner. ---> nice summary here that shows, shockingly, that we won't be facing any resurgent threat from SarsCov2 in the future, and not a year from now either, with or without a vaccine: I don't put all the blame on Fauci for no accountability and and no plan, but at some point you resign in protest to preserve integrity. So where the hell is he really coming from? it's a fucking head scratcher.

wow. not true. moving on...

what are you considering trivial vs important?

Even a hint of an actual organized directive and sense of urgency from Fauci would be appreciated. He's a milquetoast. Just my observation. With ongoing mounting evidence like this re covid and Vit D - Oral calcifediol, the main metabolite of vitamin D3, reduced ICU admission from 50% to 2% among Covid-19 patients - add this to the known list of available generic and safe options that should have led us out of this much farther by now. smh.

We've had evidence of this for long enough that most likely more should have survived than one cares to contemplate. For some reason, Fauci clearly has been in no rush to share it with all of us Americans. It's inexplicable. And I suggest inexcusable.

You can't be outside for any amount of time in PDX right now. Visibility is reduced from smoke even at 20ft where I am yet the closest fire is 30 miles away. I just drove from from TX to OR last week and got caught in WY when I-80 closed statewide from that fluke hurricane snowstorm. Drove through Green River WY where 80mph winds and snow wrecked big trees and structures. 17 inches snow reported on a mountain near Rock Springs WY. Then right into the fire hell scape.

Sweden: 2,500 randomly selected individuals were tested for ongoing covid-19. All samples were negative. Looks like Sweden is basically done with Covid. Wonder what their stance on future use/need of a vaccine will be.

forceful words from Major General (ret) Paul Eaton /siap

American J. of Medicine: Pathophysiological Basis and Rationale for Early Outpatient Treatment of SARS-CoV-2 (COVID-19) Infection

Ivermectin as a prophylactic in a study of healthcare workers in Argentina: (n=1,195) with zero infection in the treated arm vs 58% in the other. Interestingly, they also give nasal spray and oral drops to inhibit the virus at point of contact. They provide the dose ranges used when treating patients with active covid illness - totals about $15/day, cheaper than a partial* hospital bill. Ivermectin for people is readily available with an Rx from a PCP. I give my dog ivermectin every month. My dog after 3 years of continuous Ivermectin:

Outside of the large built-in costs of developing an all together new drug, what I'd like to understand is how these costs translate to working with the FDA to get use approval for substances that are naturally occurring and can't be patented, or use approval for older generics. Ordinarily new use for older generics does't require additional FDA approval as off-label use is routine once initial approval occurs for any use, but that approval would ultimately be helpful wrt insurance coverage and patient affordability (with effects on the landscape of drug competition). But for the former example, it wouldn't take much of a cost increase working with the FDA to block availability and approval for a medical use when it's not big pharma's project. This might come up where you have a naturally occurring substance that only has distinct therapeutic effects if given IV. That can necessitate compounding by a pharmacy. The FDA regulates what things are approved for compounding, and if the costs of doing that through the FDA are too high for anyone other than the big pharma co's, it likely gets smothered.

Safety first. If you're trying to translate in vitro results for in vivo human application, you first have to consider if the drug concentrations mechanistically effective in a glass contained experiment are safe concentrations applied to the human body. If not, it's a no-go. To my knowledge, the doses RECOVERY used were higher than any other known application, ever. The early safety concerns for application in covid spawned entirely from this study. OTOH, Low dose application has been repeatedly demonstrated to be safe in studies involving tens of thousands of covid patients combined and is associated with a massive beneficial treatment effect when applied before the second stage pneumonia crash happens. It's currently thought to be its anti-inflammatory effect (like used for RA and SLE) as opposed to antiviral.

A French news outlet published an interview with a RECOVERY principle investigator. The PI referenced amoebic dysentery dosing schedules as informing their dosing in a treatment arm of REVOVERY. The drugs sound very similar, but the result of such a mix-up likely could finished off a number of patients, and misinformed the world at a very early stage. Now they won't disclose their dosing methodology. Just the facts.

Thanks. It sounds like pay to play. Generally speaking, when NDA app fees increase tenfold in less than 20 years, it would appear that the result is one of culling the player pool and concentrating the the process to involve those companies that can afford to have a seat at the product approval table. If I'm one of the big pharma heavies, I'm in favor of jacking up NDA application fees even more if it diminishes competition. Again, this is not my lane, but that's one interpretation I make.

Another dodge. Shocked. Anyone could respond with the flip a coin and forever be less wrong than you. What gives? It's amusing to say the least. I've got no issue with dexamethasone at all. Unlike other safe and inexpensive early interventions, unfortunately there's not any evidence yet to support its use in the early outpatient disease state. Since it's available orally, it stands to reason it should be looked at in that capacity. However corticosteroids like dexamethasone have broad effects on innate and adaptive immunity, so getting it too soon might have unintended consequences that need to be considered first. But yeah, RECOVERY fucked up with their hcq dosing, likely killed some people (you disagree?), and as a result mislead the world.

I haven't dug into it. Perhaps the language is more nuanced in terms of how and where the money flows, but if you search 'big pharma funding FDA', just lifting up a corner of that to see what's underneath is pretty illuminating. This article jumped out: The story behind how we arrived at over $1B in US taxpayer dollars being used by Trump Admin to purchase the world's immediate supply of Gilead's remdesivir is another multi-layered story that will take time to unpack. Gilead's stock value falling back to pre-pandemic levels should tell you how that worked out. Swift maneuvering for a cool taxpayer Billion in exchange for piss.

Ana, show me a single study in the history of ever that dosed 2,400mg in 24 hrs. It ain't used for amoebic dysentery. Now, probably with the advice of legal counsel, RECOVERY investigators won't share their methodology on how they arrived at near lethal dosing for their deadly RECOVERY trial, probably because it reveals they *confused* it with a similarly sounding drug used to treat amoebic dysentery. shit happens, huh.

dotard don't run. I'll take it, but reducing mortality in "severely ill" patients is a Pyrrhic victory when better alternatives prevent advancing to severe illness and hospitalization in the first place. And that RECOVERY trial overdosed its extremely ill subjects, possibly fatally, in a particular treatment arm where they inexplicably dosed subjects in the first 24hrs an amount equal to what every other study gives over 5 days combined. it was shameful, or worse ☹️

He 'runs' faster to the bathroom after Doral fish tacos and an Ivanka garden salad.

Jenga! You can see it's the identical gait right at the 48 sec mark walking away. You will never find a video/gif of Trump running or even jogging, past or present. Will ship a mixed sixer of craft ales anywhere for anyone who can find one.

just saw this today. Some seem to think this is evidence of a stroke. To me this looks like him having knock-knees, with that Jenga gait. . If it's knock knees, he had it growing up. If he happened to have been mercilessly ridiculed about it in school growing up, that combined with those parents of his is a recipe for nuclear grade narcissism. Of course he's bragged about being some kind of stellar ball player in high school or whenever, which serves to erase the painful memory of being the opposite.

Mitch - Just pointing out what everybody already knows - the CDC's pandemic messaging and established policy implementation has been politically subverted since the beginning of this ordeal. It sounds like you have a more familiarity with the longer arc. No bones there. The FDA is a different animal because of the influence of big pharma. Harvey Risch at Yale school of Pub Health commented recently that FDA receives a third of its funding from big pharma. I can't verify that. Even if the FDA is walled off from the influence of big pharma, if you have a cheap generic that looks to be a slam dunk for a new indication going up against a patented product that is x200 more expensive per pt. and is less effective than the generic, pharma's less effective expensive drug wins out. I expect this happens mainly because there is NO ONE who is going to spend the time and effort to promote the generic option. Trump is inept at it. And if you heard his convention acceptance speech, he made a comment about being worked over by big pharma and gave a facial expression suggestive of someone being rectally probed by an unapproved medical device. The relevant HCQ data is in: That is a massive treatment effect for low dose with early administration before pneumonia sets in. 6 independent studies from 5 western nations, meaning different potential biases and covariates between studies, yet highly consistent results in direction and magnitude among all 6 studies. Over 35,000 subjects combined. No new safety issues observed with HCQ in Covid using low doses of a med that has had FDA approval for 65 years and is used off label for tens of thousands of patients daily in the US. Given the US covid caseload since March, best case is that those study results would translate into tens of thousands of Americans being alive today had this been utilized from the beginning.

I had forgotten about this re Erik Prince: NYT: Erik Prince Recruits Ex-Spies to Help Infiltrate Liberal Groups CNN: Erik Prince recruiting former spies to help with Project Veritas stings Be it Blackwater, Xi, or some yet to be recognized operation, trafficking in trained spies, agent provocateurs, and assassins is right up Prince's alley. This deliberate election strategy targeting the American public to generate a spike in fear and division needs death and chaos to succeed. Left-wing domestic terrorism and murder perp'd by "Antifa" is essentially a myth. So if you're not getting the desired level of death and chaos in the streets, what is someone like Erik Prince with his like-minded assets capable of coordinating to push it over the edge? When Trump tweets that we haven't seen nothin yet re the course of protests in "Democrat cities", in this case it's probably fair warning about whatever is planned next.

damn.