triplehorn

HCQ seemed possibly promising early on, but it was still misunderstood and misapplied -late - in severe hospitalized patients. The meta-analysis @Captainant linked just above includes studies ONLY involving severely ill hospitalized covid patients. Can't say if it's plain useless or just unfortunate they stopped including studies published after July 25. Numerous large studies have come out since then showing mortality reduction even in hospitalized patients, not to mention this week a US study showing that hazard risk of even being hospitalized is reduced almost in HALF with early outpatient use of HCQ. I know you're not posting to talk medical science, but whatever. oh, and I'm not a stock jockey. the one quoted below is. I get some satisfaction from this. It's what Ana does when he's out of answers. That, and gifs. Ana is a smart fool and occasional un-closeted misanthrope who's a sucker for the quick high. Whether it relates to subjects where he's wrestling with political betrayal or incomplete science, over time as a different reality emerges, it devolves into both-sides anastasis and evasive garden style bullshittery. Time to unblock! lollol We've thought we've had nothing to offer after testing positive yet aren't very sick or short of breath. Just stay home and hope for the best. Now we have multiple large studies in the last week (NJ n=1,067, Italy n=3,451, Belgium n=8,075) building a very solid foundation showing we have a safe available option that can save lives when started in the early stages of infection. The Belgian researchers have concluded that the mortality reducing effect of HCQ in covid is anti-inflammatory. Some will remain allergic to considering it, and some will make a call. People make personal choices affecting their health every day. It's just good to know there is even a good, safe, available choice supported by medical science.

Right, this is more about Trump trying show one time he’s not packing his beak than anything about Biden. If Biden counter offers to be drug tested every day including on the stage of every debate, Trump would pretend he ever mentioned it.

In this matter, not even a shithouse rat would understand what you're talking about. In other news, it took until late August for it come out: study from New Jersey posted yesterday shows the risk of needing hospitalization is down a massive 47% with early outpatient tx with HCQ. Not 5% less, not 10% less, almost 50% less likely to end up hospitalized with severe covid with outpatient initiation of HCQ. Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: A multi-center observational study

Here's a useful table comparing the large scale studies to date: Guess which study above had the key major impact on public perception early on? Yes, the one where the investigators may be facing criminal investigation for dosing subjects at 2400mg HCQ in the first 24hrs. It looks like a strong case can be made that they negligently overdosed patients possibly resulting in death. The other study that shaped American perception? That would be the fraudulent study published by Lancet and NEJM, later retracted. The US developed a permanent allergy to HCQ/CQ from early bad info and mistrust of leadership (not misplaced). The result appears to translate into tens of thousands of American lives that could otherwise be with us today. And not for one second do I blame any physician for avoiding treating their patients with this in the US. Even if is were green-lighted here, there's no way it would be applied to make a difference. The chaos and confusion, and lack of a coherent federal response means that the greater population, and docs, have largely been on their own. Very few docs are going to go out on a limb by themselves in this environment. Tragic, but understandable. Posting about it now almost feels like a post-mortem because indications are that globally this is a one and done pandemic that is burning out. The need for a vaccine for SARS-CoV-2 may well be obsolete by Nov/Dec. A vaccine that can help knock out annual common cold coronaviruses would be nice.

Large studies are now rolling in: Italian retrospective study (n=3,451) concludes that hydroxychloroquine reduces risk of death by 30% in COVID-19 hospitalized patients especially notable considering late stage application. What we really need to know is how much of the observed benefit from CQ/HCQ is due to early upstream anti-inflammatory actions. Yale immuno lab found that this virus codes to immediately start driving maladaptive immune responses at the outset. The viral genome is programmed to drive abnormal immune responses regardless of age or health status. Inability to clear virus quickly can lead to further maladaptive immune amplification and variably death. But looking at studies like this one: Signs of Cardiac Damage Even in Younger, Nonhospitalized COVID-19 Patients , where biopsy showed lymphocytic infiltration without presence of virus, it raises questions about broader application beyond those targeted as being at highest risk of death. As someone of low risk of death from this virus, I would be hard pressed not to briefly utilize this medication early if shown to minimize the process leading to even a glancing kiss of inflammatory myocarditis. The comparative risk of the med here is next to zero.

Your confusion over timelines is consistent with how checked out most in the US are about "what direction the evidence is growing." The evidence continuing to accumulate today shows a clear and undeniable benefit when applied early in disease course. Perhaps more significantly evidence continues to show that it is safe when applied with covid infection. Yesterday, this large study from Belgium with 8,075 subjects was published. It found that mortality hazard ratio was down 32% in multivariate analysis for patients treated with hydroxychloroquine vs standard of care. Again, no sign whatsoever of safety issues in the >4,500 subjects in the hcq group. Less than one week old, this large retrospective study from Spain focused on eosinophil recovery with 9,644 hospitalized patients and showed lower mortality for HCQ (14.7% vs 29.2%, p<0.001), and AZ (15.3% vs. 18.4%, p<0.001). With a multivariate model including potential confounding factors, HCQ and AZ are associated with lower mortality, HCQ OR 0.662, p=0.057. In light of the recent Yale immunology revelations regarding Covid gene products hacking our immune signaling pathways to amplify dangerous maladaptive immune responses, I really like this one month old study: Critically, note that treatment with HCQ is associated with lowered levels of inflammatory cytokines IL-1B and IL-6. This lends support to an anti-inflammatory mechanism of action of HCQ in reducing Covid mortality, the earlier the better. Also the other week, news from India reported 108 Million doses of HCQ have been distributed to its population for free since March. At 3.2M cases today, India has the third most cases in the world behind the US (5.9M cases) and Brazil. Deaths per 1M population? India=43 US=548. RIP indeed.

Aussie Pete Evans expands the consideration:

"A media company linked to former Trump political adviser Steve Bannon and exiled Chinese businessman Guo Wengui raised more than $300 million in a private offering this spring that is now being investigated by federal and state authorities, say people familiar with the matter. JPMorgan Chase & Co. and Wells Fargo & Co. have frozen accounts tied to fundraising for the company, GTV Media Group, some of these people said. Bank of America Corp. also closed an account for GTV Media’s parent company shortly after it was opened in recent months, another person with knowledge of the situation said. The federal probe is being conducted by the Federal Bureau of Investigation and the Securities and Exchange Commission, people familiar with the investigation said. The investigators have been examining whether GTV Media or associates of Mr. Guo violated securities laws through the private share placement. The New York state attorney general’s office has also been examining the matter, these people said." per WSJ

all of it, not just the tip ? what else do the feds know lol.

Not sure what it's going to take, but it's all too obvious there needs to be international cooperation around true global banking reform and oversight to staunch the growing decades-long river of illicit cash flow via mass international money laundering - the ability to use banks to mask transactions and conduits through the trillion dollar off-ledger economy nestled offshore. Cut off the illicit money flow and you neuter this shit from the global economic and political elite all the way down. The money fuels and sustains all this fuckery. all of it.

Just keep in mind apart from Dotard, Trump Org execs Eric, Don Jr., and Ivanka face some real criminal legal exposure here separately from NYDA and NYAG. Barr can't quash. Kiddos being indicted before or after the election would be the pin getting pulled. Even if Trump steals the election, they're going down.

Boats for Trump will all be 12 nautical miles out to sea by sunset.

One thing that ties a lot together is the money laundering - the banking. To what extent there's banking conduit/scheme overlap between Bannon and MAGA universe money laundering, this potentially could be a flare that the trail is lit.

What's this? JAK Inhibitors, a class of drug also used to treat rheumatoid arthritis appear to offer a targeted mechanism to counter the maladaptive immune inflammatory response associated with severe covid disease; particularly thought to be beneficial when applied as early as possible in the infection. Sounds familiar. What I'd like to see is an HCQ study with a control looking at Covid patients' before and after chemokine and cytokine levels guided by insights from Iwasaki's Yale collab immune signature work. Yale collab also found that increased IL-18 was the molecule MOST associated with covid mortality. That relates to inflammasome activation. HCQ has been shown to suppress inflammasome activation, not to mention its use in treating rheumatoid arthritis. There already is a lot of evidence pointing to substantial benefits of HCQ when applied in the outpatient early first stage of Covid. I suspect that looking at its specific anti-inflammatory actions as it relates to Covid pathology will help explain more specifically why it appears to be beneficial in the clinical setting, and is safe. I don't see a reason they couldn't look for a HCQ/immune mechanistic effect using the Covid infected transgenic mice.

That's certainly part of it. Burnout happens when there's still plenty of available targets, but not enough available targets to sustain active spread. It appears that there may be far fewer targets available today than we expected in order for covid to keep going and to bridge to a coming winter apocalypse and so on. An Oregon seroprevalence study out last week found x10 the number of people in OR have positive antibodies with no history of a test than was predicted. Signs are pointing to this sars-cov-2 hitting a ceiling and collapsing, and it looks to be done in various states in the US and other countries around the globe with no indication yet that it's poised for a major resurgence in those places where an apparent ceiling has been hit (~20k cases/1M pop).

In this case, it's important to consider absolute numbers of cases then and now, not deaths, as the potential we're witnessing actual global viral burnout appears to be front and center now. Various nations/regions are ahead of others.

Another explanation is that if you assume the death/case ratio is more or less the same over time within a nation/region (absent mass introduction of some effective treatment), it would suggest a whole lot more infections were occurring back in March than were tested, like maybe x30. Seems hard to think that learning on the fly to better adapt vent settings accounts for the difference lack of deaths today.

cue buffalo springfield

Yale immunobiologists identified four genetic signatures that are predictive of how you fare with covid infection. There might be some association between blood type to one or more of the genetic groups. Seems reasonable to assume that different populations within nations and between nations have variable representative distributions between the four genetic signatures. ^^^ Clusters 2 and 3 do worse. Not blood type, but yes, they can look at individual demographics and very early immune bio-marker levels to predict who's going to have more trouble before they ever crash.

Spain's increase appears to be regional. I believe their initial surge was pretty confined to greater Madrid. What Spain is seeing now likely isn't happening in and around Madrid. It's like what we saw first in NY, then with a similar delay in other states/regions. Spain still has a comparatively low incidence at about 8k cases/1M population. The US aggregate is at 17k/1M today. The select states/regions in the US that are well beyond that figure, especially >20k/1M, seem to be showing signs of spontaneous viral burnout with little to no rebound so far.

looks encouraging siap

We won't find much to agree about politically, but I'm leaning to your conclusion as well. VVVV This graph isn't from having a come to Jesus moment around masks and staying home, it's largely about being caught flat footed or opening too much too soon, and facing viral spread burnout. Re states that were late to respond/opened too much too soon, or had pops resistant to masks and isolation/distancing, once hitting 20k infections/1M population, there seems to be a progression to rapid burnout of viral spread. States that were early to shut down and got comparatively good cooperation are at post-peak levels with smaller cases/1M population. But 20k/1M is shaping up to be some kind of ceiling. Don't see this strain of SARS-CoV-2 coming back nearly as bad as the first global wave, if at all.

I wanted to summarize the Prof. Iwasaki presentation at the bottom of last page, the transgenic mouse study in particular. She describes how the coronavirus viral genome codes for multiple genes that interfere with our own cell signaling and recognition: interferon production, IFN receptor signaling, and innate INF induction and signaling pathways. The betacoronaviruses (like MERS, SARS1) are known to code for multiple evasion molecules. Her team studied the molecular cellular process of Covid infection using their ACE2 expressing transgenic mice. They selectively interfered with host innate immune responses by blocking mouse interferon regulatory transcription factors, IRF-3 and 7, integral transcription factors that drive Type I and Type III interferon production. They also knocked out the mouse Type I interferon receptor. They observed that covid virus induces interferon production despite key innate host signaling pathways being blocked. So it's a function of the viral hack that its genome products appear to be driving the induction of pro-inflammatory pathways outside of our own regulatory signaling. The thinking follows that the higher the viral load, and the extent to which it grows without early suppression, the greater the volume of direct viral signaling for induction IFN to the point where it becomes pathologic. Two of several things that appear to be linked to Covid demise are advanced age and low Vit D. Both have links to diminished innate T cell function, which is important for what we use to fight infection before antibodies are available to further suppress an ongoing infection. When our early initial viral suppression (T cell) is weak, we're more likely to have viral load grow to a point where direct viral amplification of pro-inflammatory pathways causes an array of bad things that can disable or kill us. It underscores the importance of slowing and containing the growth of viral load, and slowing or suppressing potentially key contributory inflammatory pathways, as early as possible, until even elderly with co-morbidities can clear it. Iwasaki's Conclusion slides:

Wuhan is home to a particular secure virology lab. They'll handle the transport fine I’m sure.