Nope, you have 30 cal cans which cover most of the mainstream calibers You’ll also have .46 cal cans for a bigger collection of calibers including more pistol rounds. What it will come down to is how you intend to use it, ie hunting, simple range days, heavy use/training, full auto dumps. Also how quiet you want a specific platform. For example I’ll use 2 dead air lines since I have experience. The Sandman line is built like a tank, it’s full auto rated with no barrel restrictions outside of no .22lr. The Nomad line is built to be quieter and lighter than the sandman but it also not suggested for sustained full auto, although Dead Air does list it as full auto rated they often say you should go sandman if that’s your kink. So both lines can go up to 300win mag and down to 22 hornet but the nomad will shave an average or 2-3db off the tone while the sandman is built to survive everything except a baffle strike. That being said you can go find a can designed to be put on a 5.56 ar15 and it optimizes the suppression etc, or a .22lr can or 9mm pistol can etc. deadair also sells 5.56 end caps for their .30 cal cans to help control the 5.56 beast. Most of us buy a .30 cal can to start and then keep adding to fill new needs.