What happens on the road, stays on the road (only kind of kidding)
I have a friend who has done this for almost 20 years. For he and his wife (family) it has worked well but he is an extreme extrovert, never met a stranger, kind of guy and his wife is a an introvert who he would drive crazy if he was home all the time. Honestly it has probably been the best thing for them and they have already discussed that when he retires they'll probably get a weekend place in the mountains so they (mainly his wife) can still have some solitude.
I only travel about 15% of the time and that is plenty for me and my wife's personalities.
If you go this route and kiddos arrive, after the DNA test, make sure you plan on giving your wife some real breaks (send her away by herself for the weekend) on the regular. If y'all have kids will your wife continue to work or stay home with the kids. If you're gone all the time and she is working full time that can be an added strain as well.