Labor Force Participation Rate (LFPR) = CLF/CNP
Civilian Labor Force (CLF) = All persons 16 or older that are considered employed or unemployed. Basically all persons that are either working or looking for/available to work. CLF excludes people who choose not to work (including retirees), have given up on looking for work, and people unable to work.
Civilian Non-Institutional Population (CNP) = All persons age 16 or older, excluding active duty military, incarcerated persons, and those in residential care facilities.
So, to answer your question, LFPR is effected negatively by disability. Per BLS, only like 21% of persons with a disability are employed. The remaining 79% do not work and have either no ability to work or any intent to work, and are not considered part of the labor force.
While that sounds dramatic, the same holds true for non-disabled. The vast majority of persons considered "not in the labor force", whether disabled or not, have no intent to be employed and are not looking for work.
We're at historically low levels of U-6 unemployment, which is currently 6.7%. All time low was 6.5% back in December. U-6 is the "regular" headline unemployment (3.5%) plus individuals who would like to work but have given up looking, and individuals working part-time that want, but are unable to find, full-time employment.
By comparison, U-6 was up to almost 17% in the depths of the GFC in 2009, and took close to 6 years to get below 10.0%. It stood at 7.0% in February 2020 before COVID.