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MILLION DOLLAR IDEA: "The World's Best Sandwich"
Sound like a protein nightmare for the shop to be running. There is probably a good reason business and otherwise for regional specialization.
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Anastasis started following MILLION DOLLAR IDEA: "The World's Best Sandwich"
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Greece Thread
Just booked the front end trip of a trip for this summer, AUS-LHR-CHQ (Crete). Haven't decided how long we want to stay on Crete, thinking about jumping over to Milos or Paros and then making way back to Athens for the return.
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Greece Thread
We stayed here in Psyrri: https://www.booking.com/hotel/gr/downtown-athens-lofts.html 1.3mi to acropolis. Cool area. Roof top patio view:
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Covid/Influenza/Black Death. 2024 and beyond
Good talk doc.
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Covid/Influenza/Black Death. 2024 and beyond
How many black box warnings, issued by the FDA under any administration you wish to interrogate over the last 25 years, meet your standard of hard evidence of causal relationship? I understand that lawyers have a predecilition to thinking that they understand things in particular subject matter areas when in fact their ignorance is deep and their understanding shallow. Axiomatic truths? LOFL. We do agree I think however on the struggle and motivations of parents in particular as they navigate wrongheaded public health messaging and seek answers to hard questions.
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What's happening in Iran?
I’d go pro shahshamaran or whatever if the Iranians could take that piece of shit out.
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What's happening in Iran?
John Bolton on cnn right now. I thought that piece of shit was in jail or something. Hopefully soon.
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Bomb Bomb Bomb, Bomb Bomb Iran.
Draft is not gonna be politically viable in my lifetime or my children’s timeline and probably not my grandchildren’s timeline. Thats silly talk. But I am a bit more worried after seeing helo opine
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What's happening in Iran?
Furk.
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What's happening in Iran?
Hopefully seems to only be sports related consulting.
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Covid/Influenza/Black Death. 2024 and beyond
The research is not definitive. Some studies show association with neurodevelopmental disorders, others don't. Findings appear sensitive to the methodology and design, which I think should be expected when you have complex neurodevelopmental conditions potentially influenced by a wide range of factors, genetics, epigenetics, environmental exposures, etc.
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Covid/Influenza/Black Death. 2024 and beyond
And here is the physician notice that the FDA sent out. Notice to Physicians on the Use of Acetaminophen During Pregnancy In recent years, evidence has accumulated suggesting that the use of acetaminophen by pregnant women may be associated with an increased risk of neurological conditions such as autism and ADHD in children. Some studies have described that the risk may be most pronounced when acetaminophen is taken chronically throughout pregnancy to childbirth. These concerns may be magnified by the fact that a very young child’s liver may still be developing and thus a child’s ability to metabolize the drug may be limited. To be clear, while an association between acetaminophen and autism has been described in many studies, a causal relationship has not been established and there are contrary studies in the scientific literature. The association is an ongoing area of scientific debate and clinicians should be aware of the issue in their clinical decision-making, especially given that most short-term fevers in pregnant women and young children do not require medication. In the spirit of patient safety and prudent medicine, clinicians should consider minimizing the use of acetaminophen during pregnancy for routine low-grade fevers. This consideration should also be balanced with the fact that acetaminophen is the safest over-the-counter alternative in pregnancy among all analgesics and antipyretics; aspirin and ibuprofen have well-documented adverse impacts on the fetus.
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Covid/Influenza/Black Death. 2024 and beyond
Oh good. Now the blustery bang on the table and sermonize part. You can certainly disagree with the messaging from the admin (esp in that stupid press conference). The reality is that there aren't other good solutions to bring down fever or treat mild/moderate pain in pregnant women. NSAIDs are clearly disfavored compared to APAP. So the position should be, as is reasonable, to weigh the potential risks vs. benefits, and to minimize exposure. Here is the paper that came through from DA's link earlier: https://link.springer.com/article/10.1186/s12940-025-01208-0 And the abstract: Background Acetaminophen is the most commonly used over-the-counter pain and fever medication taken during pregnancy, with > 50% of pregnant women using acetaminophen worldwide. Numerous well-designed studies have indicated that pregnant mothers exposed to acetaminophen have children diagnosed with neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), at higher rates than children of pregnant mothers who were not exposed to acetaminophen. Methods We applied the Navigation Guide methodology to the scientific literature to comprehensively and objectively examine the association between prenatal acetaminophen exposure and NDDs and related symptomology in offspring. We conducted a systematic PubMed search through February 25, 2025, using predefined inclusion criteria and rated studies based on risk of bias and strength of evidence. Due to substantial heterogeneity, we opted for a qualitative synthesis, consistent with the Navigation Guide’s focus on environmental health evidence. Results We identified 46 studies for inclusion in our analysis. Of these, 27 studies reported positive associations (significant links to NDDs), 9 showed null associations (no significant link), and 4 indicated negative associations (protective effects). Higher-quality studies were more likely to show positive associations. Overall, the majority of the studies reported positive associations of prenatal acetaminophen use with ADHD, ASD, or NDDs in offspring, with risk-of-bias and strength-of-evidence ratings informing the overall synthesis. Conclusions Our analyses using the Navigation Guide thus support evidence consistent with an association between acetaminophen exposure during pregnancy and increased incidence of NDDs. Appropriate and immediate steps should be taken to advise pregnant women to limit acetaminophen consumption to protect their offspring’s neurodevelopment.
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Covid/Influenza/Black Death. 2024 and beyond
Again, you should not lecture anyone on reasoning and understanding of the english language. I asked a question. When flippantly responded to, I replied that they did not report any clinical outcomes one way or the other. You are litigating against a hallucination, persisting even upon going back and re-reading the exchange. Enjoy the wet shoe.
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Covid/Influenza/Black Death. 2024 and beyond
Attacking reasoning and ability to understand the English language while pissing down your own leg is certainly a rhetorical tactic. "We recommend judicious acetaminophen use—lowest effective dose, shortest duration—under medical guidance, tailored to individual risk–benefit assessments, rather than a broad limitation."