Everything posted by Anastasis
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Charlie Kirk Assassinated [Shooter in custody]
Yep. The close up of the neck shot looks straight jugular. He's dead.
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Charlie Kirk got ded, Erika Kirk grifts in place
Maybe better to say it's gonna get to be more popping.
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Charlie Kirk got ded, Erika Kirk grifts in place
This shit is about to pop the fuck off.
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Charlie Kirk got ded, Erika Kirk grifts in place
That's a neck shot and he is dead. If that was a deer it wouldn't make it 20 yds.
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RFK Jr. off the chain and off his rocker
I would prefer an outright ban on DTC, but the argument is that that would trigger cases on 1st Amendment grounds. The ads are already mostly a recitation of adverse effects. I guess if you force them to read the whole package insert you could make the ads cost prohibitive and more annoying than they already are, but this doesn't get rid of them. The social media component is also a good area that needs some cleaning up. I don't have much hope that this actually does anything useful until we see actual enforcement and some skull cracking.
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Surly #Stonks
And certainly in a heavily regulated space like pharma/healthcare. I've lost far more money in small biotech than I have ever made. I swore them off for a while. Well shit, I guess it was.
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Surly #Stonks
Re: IBRX, this release today. Positive phase 2 data in lung cancer, let's land a phase 3. ImmunityBio’s ANKTIVA® Reverses Lymphopenia and Extends Overall Survival in Patients With Advanced Non-Small Cell Lung Cancer Resistant to Checkpoint Therapy September 8, 2025 PDF Version Severe lymphopenia, an adverse treatment effect associated with chemotherapy, radiotherapy, and immunotherapy, significantly lowers overall survival in non-small cell lung cancer and multiple types of cancer.1,2 With ANKTIVA, the first FDA-approved lymphocyte-stimulating agent, 80% of patients exceeded or maintained absolute lymphocyte count (ALC) above 1,000 cells/µL. With ALC counts greater than 1,500 cells/µL, statistically significant prolonged median overall survival (OS) of 21.1 months occurred with patients alive ranging as long as over 4 years in stark contrast to the historical 7 to 9 months survival with docetaxel in these patients with advanced lung cancer. Findings from the Phase 2 QUILT-3.055 study presented at IASLC 2025 World Conference on Lung Cancer in Barcelona, Spain represent a paradigm change in a chemotherapy-free treatment of lung cancer by activating Natural Killer cells and T cells, the lymphocytes key to inducing cancer cell death. Patients are currently being enrolled in the randomized Phase 3 ResQ201A trial (NCT06745908), which is evaluating ANKTIVA + tislelizumab, a checkpoint inhibitor versus docetaxel alone in second-line NSCLC patients who have progressed after all standard therapies, including checkpoint inhibitors.
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Tracking Trump Administration and Cabinet picks
lol at the propaganda.
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Things not going well in Venezuela
*laughs in drone strikes*
- Austin FC
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Things not going well in Venezuela
They are using the 2001 AUMF as cover for this shit. Are we ever gonna fn learn.
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RFK Jr. off the chain and off his rocker
His buddies at Mt Sinai and TH Chan. Shit they are regretting that paper at this moment, and probably looking for ways to walk it back. Or angling for the gov grant funding, more likely. Nothing like that tit.
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RFK Jr. off the chain and off his rocker
Not sure I learned and certainly don't recall the specific MOA either. NSAIDs of course, and CoxII's. Fn Merck man.
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RFK Jr. off the chain and off his rocker
Oh, and if this is type of stuff they are talking about in the Sept big reveal, it is as I expected. No new novel data, or studies. It's not even meta analytic work, just a lit review. Should not move the needle in a substantive way at all. Maybe they announce funding for studies, but certainly not landing anything substantive.
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RFK Jr. off the chain and off his rocker
Seems like there has been an ongoing line of inquiry into APAP exposure and neurodevelopmental issues. Wasn't something I was aware of at all. Here is a systematic review published last month. Lead author from Mt Sinai, senior author from Harvard TH Chan: https://ehjournal.biomedcentral.com/articles/10.1186/s12940-025-01208-0 Man, that's a epi challenge. You will never get a definitive answer. Exposure misclassification (OTC drug), impossible to assess all the potential confounders, outcome potentially influenced by variety of genetic and environmental exposures, unethical to do RCT work. The swedish study cited up thread is included in the review, and discussed in some detail in the discussion section. Even if you see an association, you are never gonna pull the drug...guidance will be as it is in current state...minimize dose and duration as indicated. Results We identified 46 studies for inclusion in our analysis. Of these, 27 studies reported positive associations (significant links to NDDs), 9 showed null associations (no significant link), and 4 indicated negative associations (protective effects). Higher-quality studies were more likely to show positive associations. Overall, the majority of the studies reported positive associations of prenatal acetaminophen use with ADHD, ASD, or NDDs in offspring, with risk-of-bias and strength-of-evidence ratings informing the overall synthesis. Conclusions Our analyses using the Navigation Guide thus support evidence consistent with an association between acetaminophen exposure during pregnancy and increased incidence of NDDs. Appropriate and immediate steps should be taken to advise pregnant women to limit acetaminophen consumption to protect their offspring’s neurodevelopment.
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RFK Jr. off the chain and off his rocker
Wait. Who is getting sued? The WSJ?
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Austin School Shooting Threats
Don't take it personal, was just a jump off point. I am past having any tolerance for parents of minor children that are involved in these situations. Default is "throw them in jail too." Certainly, if you can provide evidence that they don't deserve to get rung up, I am happy to accept that.Too many recent examples man. But default is now "fuck them too until proven otherwise". I say this as a man with a shit load of guns and a couple boys, so believe me I understand the implications.
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The Fuck This Scumbag Thread
That can't be a real quote. Also would like some tight in shots of the mom.
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Who's been covid vaxxed? Stand up and be counted.
Pfizer is charging too much, so we need to recommend that all 15 year old boys get the booster is some next level galaxy brained absurdity. What a fucking system.
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Cheese Enchiladas
- Who's been covid vaxxed? Stand up and be counted.
Because it is not true. Any physician in the US can prescribe or directly administer a COVID booster based on their individual risk profile. I realize that some states put restrictions on what pharmacists can administer without a physician order. I am generally opposed to those state laws and would support changing them as Colorado recently did. I think that an insurer would be foolish to restrict coverage. But you've evaded the point as to whether the CDC should be making a universal recommendation for healthy adolescent males. ACA requirements that tie required coverage to ACIP/CDC guidance is not a recommendation based on medical evidence and risk/benefit analysis, it's a justification based on the dysfunction of our healthcare financing system.- Who's been covid vaxxed? Stand up and be counted.
This is like discussing with religious fundamentalists. Booster uptake is shit. 10-20% depending on which numbers you look at. The messaging is not and has not been working. But maybe we should just do more of the same.- Who's been covid vaxxed? Stand up and be counted.
Let me ask you this Twice. Based on what you know, do you think that we should be boosting a healthy male adolescent? You think it invalid to point out that this is a silly recommendation, and to point out the absurdity of the position that we have to tell that adolescent male to boost because we don't know how to get 70 year olds with COPD to take a booster any other way.- Cheese Enchiladas
Let's be honest. I'd probably just eat the tortillas and the extra beans and not have any leftovers.- Who's been covid vaxxed? Stand up and be counted.
Yeah, that was the other politically charged topic I was referring to in that quote that fuggled picked up. The juxtaposition with stable flu vax recs across countries and citing the environment factors that are part of the consideration are reasonable points. But everyone is working with the same evidence wrt COVID boosting. Our approach has largely been to take that evidence and spit out one size fits all recs. I'd call that reductive, and I certainly would not call it strongly evidence based. What we are talking about here is ongoing adjustment and refining of COVID booster recs. Sweden, UK and Australia, as examples, all recently tightened up their booster recs to focus on high-risk individuals. You don't hear the absolutely political wailing and gnashing of teeth about it like we get here when people start talking about tightening up the recs. I am open to the argument that most Americans are too stupid to digest risk-based recommendations, so we just tell everyone they need to do something. But don't act surprised if that approach ends up undermining the credibility of the messenger. But tell me more about misleading others intentionally, lol. - Who's been covid vaxxed? Stand up and be counted.
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