So two years ago my wife and I went to Ireland for the first time. Flew into Shannon and drove through Killarney National Park, did some hikes and spent the night in Kenmare. Drove Ring of Kerry the next day to Dingle and spent three nights in Dingle. Drove the next day through Cliffs of Moher and the Burren to Galway and spent a night there. Next day drove through the Connemara and spent the night in Westport. Next day back to Shannon and spent the night at hotel next to the airport for flight out next morning (all these days driving involved stops and checking out ruins, etc.) Loved the trip, but felt it was too much driving. Even though the distances aren't that much, it is definitely slower driving and mentally tiring, but not impossible.
Last month we went back, again flew into Shannon and drove directly to Dingle. Spent three nights there, then three nights in Ballyferriter, a village of about 200 people 5 miles from Dingle. Trip was incredible. Got to know many people in the pubs, particularly in Ballyferriter, explored all of the Dingle Peninsula, played a few rounds of golf at Ceann Sibeal, and just had a great relaxing time. Talked to people about Gaelic football in the pub--so cool how these tiny villages have their own team. Mentioned that I wanted to get a jersey from the local Ballyferriter team (Gallarus), and a young guy at the pub said he would drop off one of his game-worn jerseys at our hotel. The trip was incredible.