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Txzen

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Everything posted by Txzen

  1. Compassionate use of Remdesivir for Patients with Severe Covid-19 : New England Journal of Medicine, April 10 Details : 53 patients with severe complications, international cohort 34/53 (64%) were on mechanical ventilation Treatment resulted in an improvement in oxygen support class for 68% or patients over a median of 18 days following the first dose More than half were extubated 47% were discharged following treatment Clinical improvement less frequent among patients on severe ventilation versus noninvasive ventilation, and among patients at least 70 years of age
  2. Perhaps for a few who are very ill, but it's a placental-derived stem cell therapy, and not likely to be mainstream therapy any time soon.
  3. Perhaps, but it's also the scale of production for whatever that treatment is. We know already that there are shortages of hydroxycholoroquine (and that's due to some minor hoarding and its expanded used in trials), and while Gilead is spooling up production of rendemisvir, right now the supply is only 1.5 million doses. It's possible that the production and rollout of a vaccine may be the only way to really 'control' this. I'm not sure there's enough supply of drugs worldwide for everyone to be prescribed these meds, and certainly not for prophylactic use.
  4. Daily reported deaths per capita (7 day average) vs. total reported cases:
  5. Study to test if COVID was in California earlier than previously thought Will be interesting to see the data from this.
  6. Yes, cardiac issues are a potential side effect of both hydroxychloroquine and azithromycin for a population of patientis even when given individually, which is why co-administration is potentially tricky. American College of Cardiology
  7. Full disclosure, I'm a cancer research guy, not infectious disease. But certainly many of the animal models for human infectious diseases are fraught with limitations just like those in oncology. The Gilead drug remdesivir, for instance, looked good in vitro for Ebola, and pretty good in primate disease models models - but perhaps has not shown as much promise in the field. The primate models are so-called semi-permissive for Ebola (and also some respiratory viruses), meaning that the disease often doesn't quite take hold as well in monkeys or is not as sustained as it is in humans. So, testing of the drugs in these models often is early on after exposure to the infectious agent to show if it has an impact. Compare that to treating people in the field where Ebola has sprung up - people in all the various stages of disease, long after being infected with various levels of disease burden and the resulting complications of other systems involved. It's not so simple to make the leap from preclinical to clinical. It all highlights the need for the continued clinical trials of all of these agents alone or in combination, as is ongoing now. Sporadic reports of a few patients treated here or there is not conclusive evidence of efficacy.
  8. COVID deaths, per capita by state for April 5th : link. Low numbers likely 'noisy' due to low death counts. Regional incidence, per capita : East South - DC coming on strong, hoping LA begins to flatten Midwest West
  9. One never knows if this is just lazy science ignorant journalism, or if he actually said this. Among all the mechanisms of action described for hydroxycholorquine from it's use in rheumatology, autoimmunity and infectious disease, 'opening a channel' ain't one of them. The fact that he thinks this illuminates the need for the (current ongoing) world-wide clinical trials.
  10. Best source of graphs, per capita at state/regional level, as percent of population (super helpful way to look at the data, frankly) : https://twitter.com/isfBob Case density as percent of population, worldwide: Mid-West : South: Northeast: West:
  11. No. Not approved - authorized for emergency use, there's a difference. Along those lines, Gilead pulled back remdesivir from compassionate use - which is a process that allows a new, unapproved drug to be used for people who have no other treatment available. The issue is that those are often done as one-off, small group studies as was done for Ebola. It's not the best way to understand the efficacy of a drug during a pandemic. This was done to enable larger, world-wide clinical studies like the SOLIDARITY Study by the WHO, as a part of a process called 'Expanded Access' which allows the testing of larger groups of people simultaneously under a single blanked designation. The study will test thousands across the globe in a randomized adaptive trial looking at multiple single-agents and combinations :
  12. 45/60 choir singers contract COVID from one practice. It’s likely the setting, proximity and nature of singing contributed but at least shows how easily it can be spread by airborne droplets.
  13. On the topic of when we knew, there were certainly some in the scientific community who had predicted this some time ago.
  14. https://i.ibb.co/k9RXRKh/IMG-2432.jpg
  15. Amid frenzy over potential COVID-19 drug, patients see shortages and states fight reckless scripts
  16. Sorry if already posted : Party Zero : How a Soiree in Connecticut Became a 'Super Spreader'
  17. Liquor store is open in my Bay Area neighborhood. Not sure if it’s an anomaly but I’m not questioning it.
  18. Was there right before New Years. Wife ripped up her knee - went to the Vail hospital at the base. Couldn’t get a room as the place was overrun with flu patients. Too early for COVID I think, but certainly there’s been a few hot spots worldwide at resorts.
  19. How about published research then : The proximal origin of SARS-CoV-2, Nature Medicine In-depth molecular analysis, with the final conclusion:
  20. Perfectly fine for pre-teen. No blood, very cartoon-like. Creative mode where you build your own world, is fun. My 12yo has been playing since he was ~10.
  21. A cloth. To clean. Between people sharing a highly communicable disease. That's some real turn-of-the-century logic here. Bet you didn't pull the paper. I did. Interesting first that simply putting this text in google pulls up mentions on dozens of Christian websites, so this clearly this argument makes the rounds in the religious circles. And I quote : link In 1988 - which is why they were looking at HIV transmission. Do you know how different COVID-19 is from HIV and hepatitis B? Just curious.
  22. Also : https://www.penguinrandomhouse.com/books/200682/the-coming-plague-by-laurie-garrett/
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