Baylor beat them at home 46-0 in 1901 (according to Google AI) ... Worst loss at pyle for the farmers. I can see Texas putting a 65 - 10 or less beating on them next season.
From the Google AI on the prompt - Worst loss at home for Texas A&M Football -
Defining "worst" can be tricky, but there are a couple contenders for the worst home loss in Texas A&M history depending on how you weigh factors like score and opponent. Here are two that frequently come up in discussions:
1901 vs. Baylor (0-46): This one holds the dubious honor of being the biggest defeat ever suffered by the Aggies at home. Baylor, which is now a Big 12 conference foe, was a much weaker program at the turn of the 20th century.
2008 vs. Arkansas State (14-17): This loss was a shocker because Arkansas State was a major underdog from a much smaller Sun Belt Conference. It was also the Aggies' first home opening loss in over two decades, marking a low point for the program at that time.
Some fans might also mention the 2017 Rose Bowl vs. UCLA (44-45), where the Aggies famously choked away a huge lead. However, that wasn't a home game.