What's pretty goofy is that so far I've found out that the best run defense, for me so far, is a cover 3 or cover 3 match. No, that absolutely should not be the case. The Will and the dollar back on the outsides are supposed to float back and cover the seam but they see the run instantly. Even bad players in that defense will crash down on any outside run, making it easier to funnel the back inside toward traffic. Also, the mike will float close to the middle and pursue the edge or the inside at the same time. Kinda dumb, but it works.
If I run blitz or guess with slides I get roasted by the running back. Stacking the line usually leads to the back hitting a clean gap in traffic and they're gone.
Outside of that and the instant pass rush, the concepts are mostly spot on. It's the best gameplay in any football game I've ever played. If you try to spam the same play just twice or even run similar route trees in different formations the cpu will slap you in the mouth.