I think there is certainly a possibility of a realignment, with some transitional period where a third party is generated, pulling significantly from both the conservative Dems and never-Trump Republicans - sort of the old guard.
In Omaha, this is sort of thing is happening now. Kara Eastman is running as a progressive challenger to Republican Don Bacon. In 2016, Bacon had defeated Brad Ashford, a centrist Dem who had previously been a Republican. In 2018, Kara beat Brad in a close primary. In the 2020 primary, Brad's wife Ann Ashford was throttled by Kara, in roughly a 2:1 margin. A couple of weeks ago Brad endorsed Bacon against Kara. Earlier this summer, County Attorney Don Kleine, a registered Dem, decided not to press charges against a bar owner who had killed a black protester and claimed self defense. He was pressured into calling a grand jury, which indicted the bar owner. Eastman had called out the killing of the protester. Kleine criticized her for it. Now Bacon is running ads with an endorsement from Ashford and the criticism from Kleine. Kleine has even publicly stated he voted for Trump. It is definitely an old conservative white guy faction (both R and D) against the progressive Dem. Granted, I think a lot of this personal rather than policy, but there is a cultural difference that will lead to personal rifts.
I could see that kind of dynamic happening on the local level elsewhere, and nationally. If the Dems win the White House, the Senate, and the House, there will be a lot of in-fighting on what needs to be fought for. That will put a lot of pressure on any existing cracks in the party. I think the progressives win control of the party. They are making too much money to be ignored. It is a little ironic.