TwiceHorn

Another thing I might add, all you can do is the next right thing, whatever that is. So, all this grief and everything else threatens to overwhelm. Just do the next thing you gotta do, whatever it is. Don't look past it, just do it. Then do the next one. Take a break in between. Rinse and repeat.

Exactly what I was driving at with the third sentence. There's something strangely comforting in knowing you're not alone in your struggles.

Just started it after seeing a rec somewhere online. I am a sucker for matters nautical in all cases, so the depiction of shipboard life in the mid-19th century captivates. So, setting that aside, enjoying the rest of it too. Glad others concur.

The arrests of these people were not overnight, they're still ongoing. And these being convicted after trial are exercising their right to a trial or jury trial, which 90% of federal criminal defendants do not do. Trials take a minute or two. And we the people don't fund enough courts, judges or prosecutors to hold the number of trials necessary to get the plea-bargain rate down. This particular guy was arrested last September, so that is lightning fast. A year is about the fastest trial resolution you'll find in any court anywhere (other than maybe JP courts on shitsplat civil matters or traffic tickets).

Good advice here all around. As pointed out, getting out and making yourself of service to others can be a big help to your mental well-being. Also, you are indeed going through a very rough period with which we can all sympathize and empathize. Personally, but your mileage may vary, but I often find it helpful to remember (or be reminded) that everyone goes through variants of the same shit, death, divorce, depression, etc. Most of us survive it and prosper and you will. too. As much as I like to think I'm special, my problems tend not to be worse than anyone else's, and I am no more especially capable of dealing with them than anyone else. This too, shall pass. Please do not take this as minimizing your pain. I get it. Just offering a bit of perspective.

Even had it emerged from the congress, I'm sure ratification would have been a long, hard road.

Aren't most or all of Leddy boots custom made?

I agree that any pricing shenanigans, predatory, gouging, whatever, should not be effective, but over a longer term. And consumers seem to have been quite complicit in the inflationary pressure by not changing their buying behavior much at all, despite bitching to high heaven about it.

Every time I see Pitt in a suit, I think "Westray." I actually like that movie, quite a lot.

I think that is (or at least was) patently unconstitutional. https://en.wikipedia.org/wiki/Privileges_and_Immunities_Clause

Only Cougar high would have the Houston skyline as part of that design.

Many of you are too young to remember, but back when Nocona made real boots.

Not nearly as easily as 30 years ago. I'm not sure I would set hard limits on where my kids could go. But I might apply gentle pressure as my mother did when aggy was on my list: do you really want to deal with being an aggy all your life? No, Mom, you are right thanks for the reminder.

While you could be correct that it is overblown or out of context, numerous articles state that Andy Groff, Kroger's pricing head, confronted with emails, admitted that they raised prices beyond that necessary to pass through cost inflation.

@Bozo_Casanova Your thoughts? From what I can see, Kroger has had consistently lower prices by a little bit, than tt/albertsons.

So, should have known the 88 is a Nazi reference, not birth or graduation year. https://www.facebook.com/mhanna88/videos/ Piece of shit.

Who is this embarrassing motherfucker?

Stupid and inferior.

It looks like what they did is treat an NDA as an act of infringement, which is a thing, like Patent Term Restoration, only available to pharma. And, it's not just Abbott. It's errbody. I am unaware of any pharma the doesn't "game the system." Pharma patentees are somewhat disadvantaged because the FDA approval process could prevent marketing and selling (and profiting and recoupment of costs), until well into the 20 year patent term, depriving pharma of the rights more or less available to everyone else. But the compensations we have in the system, restoration and shit like an NDA is an act of infringement, seem to have gone overboard. Also, the grant of exclusivity by the FDA upon approval, patent or no, seems extravagant. https://www.fda.gov/files/drugs/published/Exclusivity-and-Generic-Drugs--What-Does-It-Mean-.pdf

Also thought I would look at their European Patent. It appears they only sought patents in US, EU, and JP. One of the biggest knocks on the US system is that you can file endless continuation applications, which are all the same application, but with different claims (sometimes to markedly different subject matter, sometimes not). Regardless, continuations themselves do not extend patent term, they all expire on the same day, 20 years from filing of the first application. In a lot of senses, a "family" of continuation patents can be regarded as one big patent. The EU and most other jurisdictions don't allow that. But Abbott let the first European Patent application, corresponding to the above, die on the vine, and have filed a "divisional." A divisional is allowed when an Office tells you you are claiming more than one invention in an application, that is, you have claims to a composition, a dosage, etc. Each would be regarded as a different invention and you have to file a second, third, etc. to seek the other types of claims/inventions identified. So, shenanigans have ensued. The biggest booger in the US is the Patent Term Restoration act, which treats drugs and devices subject to approval differently than everything else. The maximum attainable term is supposed to be 14 years from approval.

Yeah not sure where I got the "month's supply" re-reading, Just says 85gpb for a vial. Yikes

On a semi related note, I see that RR has tarted up the Defender significantly. That seems like a shame.

I did find what seems to be the basic patent for the composition. https://patents.google.com/patent/US20190224220A1/en What's interesting is that that one there was allowed, but instead of letting it grant, they have filed four continuations, none of which have been granted. And each of them has a non-publication request, so are unpublished, meaning the public and competitors can't see what they're doing with the coverage. The earliest filing date of that family is 2017, so all patents would expire in 2037 or thereabout. So this strategery I guess delays grant until something closer to marketing in the US, but has also eaten seven years of term, or half of it. But I guess they're going to get some of that back due to Patent Term Restoration. https://www.fda.gov/drugs/cder-small-business-industry-assistance-sbia/small-business-assistance-frequently-asked-questions-patent-term-restoration-program I saw they charge 85GBP for a vial (a month's supply) in the UK, before discounts etc. Don't see what they charge for the pump.

I'd be interested to see the patent situation here. As you note, C/L is a standard, old treatment, so I'm sure the chemical composition with efficacy patents are long expired. There may be something chemically/pharmacalogically new about this variant, though. That may leave dosage patents and the infusion machine, to the extent there's anything patentable about that. Patents or no, Abbott is going to get 6 years of exclusivity upon approval.

Get a front row bulkhead seat. It's really no worse than any other domestic airline these days.