Like gator said, there’s many, many different drugs, so there can be a spectrum. I took AAVD for Hodgkin‘s Lymphoma. This includes Adcetris (name brand for Brentuximab vedotin), Adriamycin (the ‘Red Devil’), Vinblastine, and Dacarbazine. They will generally give you an antiemetic first, along with Benadryl (this is how I learned that I am allergic to fosaprepitant; the only thing I have ever been allergic to so far in my life). In my case, the only thing that really gave me issues was the Adriamycin. They call this one the Red Devil for a reason (it is also red in color compared to colorless for the order three I took). It sucks. It can also cause mouth sores and thrush, so they suggest sucking on ice to help prevent it. I wound get so nauseous while receiving it that I could not do the ice after a while. Luckily for me I did not develop mouth sores. When you pee it out your pee also looks like rosé, so that’s something, I guess. Speaking as someone who received chemo thru a port in my chest, I didn’t really “feel” anything physically when receiving the actual infusion, except for when they did the port flush with heparin. You could almost taste it in your mouth when they did that. Mostly a kind of saline solution taste. What comes after is the worst part for most people. I was okay for about 1-2 days after, then the heavy nausea and flu-like symptoms set in. These would last about a week for me, sometimes 10 days or so. My chemo cycles were 14 days, so I was lucky if I got a few days of feeling “OK” before starting all over. I also had really bad insomnia for about the first 4 weeks, but luckily that mostly cleared up. I lost my appetite for a while and subsequently lost a lot of weight. I lost a ton of muscle in my lower legs due to motor neuropathy, and still have weakness and nerve damage there and in my hands, which I’ve posted about in here before (I am still improving though). I could actually feel my calves getting tight from the start, and while I mentioned this to my oncologist, if I had known what this meant I would have spoken up about it even more (I did get dosage reduction later in my regimen). That said, some people experience almost nothing except a bit of the flu-like symptoms. Some get to toxicity level and have to stop a drug completely. Some of the drugs can increase chances for other cancers later or damage your heart, lungs, liver, or just about anything, really. There so, so, much more that I have forgotten, and also many, many more things that others experienced that I did not that I could not tell you about.