That's a good time to come. Bummer that the Twins won't be in town.
I'm really not aware of many new and trendy spots downtown, but some of the spots already listed in this thread are gone, so I'll restate my favorites.
Spoon and Stable- Get a reservation soon
Bar La Grassa- I've never been disappointed
Butcher's Tale- Used to be Butcher and the Boar. The place to go for a whiskey drink.
Union Hmong Kitchen- This one's pretty new and I haven't been yet, but it's a Beard nominee and where the hell else are you going to get Hmong food than the Twin Cities (huge community here)?
Key's Cafe- Hangover breakfast.
Freehouse- It's more of a restaurant, but they brew their own beer and it's location is a perfect lunchtime jumping off point for a North Loop beer crawl.
Trivia Mafia- If you like trivia, this company operates hosts trivia at a bunch of different spots. Their website will tell you what you need to know.
Breweries... Damn, there's so many. First, read this to help develop a plan: https://wanderlustinreallife.com/twin-cities-brewery-crawl/
My favorites (in no particular order) are Modest, Pryes, Duel Citizen, Fulton, Surly, Indeed, Barrel Theory, Tin Whiskers, Dangerous Man. That's off the top of my head. I'm sure I'm missing some.
Oh, one more. Though I don't go there often, you may really appreciate the concept behind The Lab https://thelabmn.com/