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PsychMike

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Everything posted by PsychMike

  1. This is from the study protocol, Page 4, beginning at Line 58: They used a loading dose plus high doses to get what they calculated as the levels needed to inhibit the virus. The key to getting effective kill rates with antimicrobials is getting sufficient drug levels to the target, while avoiding excess toxicity. It seems like a reasonable approach for a hospital study with adequate monitoring in the context of severely ill patients.
  2. yeah, that Pence, he like boys.
  3. That title is too complicated. I'd just go with "The Aristocrats."
  4. And now she's into Dynamic Meteorology, so I am sure your statement applies for that too. She may be cray, so use false names and have an exit strategy...
  5. Just so we are clear, peanut butter-rubbed brisket, specifically Butterfinger-rubbed, is a thing and it's delicious!
  6. I've been wondering this myself (well, I wasn't limiting my thoughts to those organ systems). My friend's wife is having strange neurological symptoms that they're getting checked out. He was wondering if she has some sort of post-viral syndrome, but she never had any Covid symptoms. I mentioned that stat above about most people being asymptomatic, and we both wondered if asymptomatic carriers can eventually develop some sort of organ toxicity. I've given up on trying to apply my clinical intuition to this virus. It's an enigma.
  7. Hell yeah, and keep her there. None of the Veep speeches to elementary schools and scouts while Congress is in session.
  8. Holy shit, it's Lady Liberty! And there's no tourist crowd! Honey, clear your schedule, we are going to the Center of the World.
  9. Now there's a guy I could vote for...RIP Mr. Candy!
  10. Narrator: no, but it does have to be effective and it needs to have a more pronounced effect than the two drugs that have proven effective!
  11. Given this thread and your avatar, is there a thread where I can read some of your stories on this? (I know this thread is not the proper place) I saw that Galveston county had 5% yesterday. Does anyone remember how many days in a row this threshold should be met?
  12. Aw, shit, didn't see that you already posted.
  13. too slow
  14. Also, I think Louis Gohmert's mask had a role in Herman Cain's death.
  15. Ernst and Collins took the same advertising class I see. Political advertising has no class at all. Mays Gilliam. He's for Cancer!
  16. You forgot the Pay Per View aspect to help pay down our National Debt. "Get your tickets to Trumpacobra 2020!"
  17. Yes, CV safety. There's a section titled "Risks‐Benefits of Combining the 2 Drugs" in the article I linked above.
  18. I'm not going to try to copy/paste due to formatting issues, but here's a link to an interesting article discussing the putative MOA of HCQ +/- AZ, along with a Table summarizing evidence to date. It's quite interesting. Unfortunately it's only got two legs of the proverbial tripod (can't speak for Zn). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280673/
  19. FYI, when I took Drug Study Design during my PharmD coursework back in the early to mid 90's, the faculty was from McMaster University in Canada. Guyatt is the guru. There is a systematic approach to evaluating the base of evidence to inform practice. As has been mentioned here, sometimes you don't have good RCTs to inform practice. You do your best with extant data. If you are a well-trained clinician, you use your experience, intuition, and things you learned from pedagogic teachings to fill in the gaps. Now here's the thing. If you DO have good RCTs that point in one direction, but you want to bend towards a bias (wherever the bias comes from, ie cute sales rep), you deserve whatever malpractice suits and negativity headed your way...especially when your patients are harmed. All this said, in the absence of effective, curative medicines, there are numerous strategies clinicians must employ. There's no question that politics has entered the arena on this approach, which is unfortunate because some clinicians are still trying to do their best with what they have in front of them. Bottom line: multiple RCTs demontrated no benefit of HCQ, which outweighs the supportive evidence base, which consists of zero blinded, well-designed RCTs that I can find. If the scientific community can sort through everything learned thus far regarding HCQ, I have no issue with informing new strategies to be tested via adequately powered, well designed RCTs, although Anastasis make a good point about the competition between studies and the precious resource of how many eligible patients are proximal to qualified research sites.
  20. Level of evidence (LOE) Description Level I Evidence from a systematic review or meta-analysis of all relevant RCTs (randomized controlled trial) or evidence-based clinical practice guidelines based on systematic reviews of RCTs or three or more RCTs of good quality that have similar results. Level II Evidence obtained from at least one well-designed RCT (e.g. large multi-site RCT). Level III Evidence obtained from well-designed controlled trials without randomization (i.e. quasi-experimental). Level IV Evidence from well-designed case-control or cohort studies. Level V Evidence from systematic reviews of descriptive and qualitative studies (meta-synthesis). Level VI Evidence from a single descriptive or qualitative study. Level VII Evidence from the opinion of authorities and/or reports of expert committees.
  21. Agree. Also, if the medical community at large doesn't seem to do a good job of sorting out levels of evidence, how can we expect the lay public to do so? BTW, I'm not suggesting doctors don't understand levels of evidence, but rather it is common to see rampant disregard of evidence-based medicine based on bias or other factors (an example is the use of antidepressants in Bipolar I Depression). Take a look at this quote from Dr. Birx around the time the task force was rolled out: So I know that she is highly trained and I am sure she understands levels of evidence, but WTF? I have always hoped she was pressured into saying that, or that she just worded her sentence poorly and meant something else. Argumentum ad populem is a BS political tactic and should never be amplified by medical experts.
  22. LOL at her 2nd tweet!
  23. Ya know, I enjoyed the hell out of Reggie McNeal lighting up OU for 4 TDs, despite the fact that I can't stand the dude and that lame ass program that he played for. But I have no regrets enjoying the hell out of it.
  24. What kind of name is Yoho, anyway?
  25. Did they use the Fisher's exact test? There's always something fishy about stories like this where they get the test bass ackwards.
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