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PsychMike

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Everything posted by PsychMike

  1. Yes, CV safety. There's a section titled "Risks‐Benefits of Combining the 2 Drugs" in the article I linked above.
  2. I'm not going to try to copy/paste due to formatting issues, but here's a link to an interesting article discussing the putative MOA of HCQ +/- AZ, along with a Table summarizing evidence to date. It's quite interesting. Unfortunately it's only got two legs of the proverbial tripod (can't speak for Zn). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280673/
  3. FYI, when I took Drug Study Design during my PharmD coursework back in the early to mid 90's, the faculty was from McMaster University in Canada. Guyatt is the guru. There is a systematic approach to evaluating the base of evidence to inform practice. As has been mentioned here, sometimes you don't have good RCTs to inform practice. You do your best with extant data. If you are a well-trained clinician, you use your experience, intuition, and things you learned from pedagogic teachings to fill in the gaps. Now here's the thing. If you DO have good RCTs that point in one direction, but you want to bend towards a bias (wherever the bias comes from, ie cute sales rep), you deserve whatever malpractice suits and negativity headed your way...especially when your patients are harmed. All this said, in the absence of effective, curative medicines, there are numerous strategies clinicians must employ. There's no question that politics has entered the arena on this approach, which is unfortunate because some clinicians are still trying to do their best with what they have in front of them. Bottom line: multiple RCTs demontrated no benefit of HCQ, which outweighs the supportive evidence base, which consists of zero blinded, well-designed RCTs that I can find. If the scientific community can sort through everything learned thus far regarding HCQ, I have no issue with informing new strategies to be tested via adequately powered, well designed RCTs, although Anastasis make a good point about the competition between studies and the precious resource of how many eligible patients are proximal to qualified research sites.
  4. Level of evidence (LOE) Description Level I Evidence from a systematic review or meta-analysis of all relevant RCTs (randomized controlled trial) or evidence-based clinical practice guidelines based on systematic reviews of RCTs or three or more RCTs of good quality that have similar results. Level II Evidence obtained from at least one well-designed RCT (e.g. large multi-site RCT). Level III Evidence obtained from well-designed controlled trials without randomization (i.e. quasi-experimental). Level IV Evidence from well-designed case-control or cohort studies. Level V Evidence from systematic reviews of descriptive and qualitative studies (meta-synthesis). Level VI Evidence from a single descriptive or qualitative study. Level VII Evidence from the opinion of authorities and/or reports of expert committees.
  5. Agree. Also, if the medical community at large doesn't seem to do a good job of sorting out levels of evidence, how can we expect the lay public to do so? BTW, I'm not suggesting doctors don't understand levels of evidence, but rather it is common to see rampant disregard of evidence-based medicine based on bias or other factors (an example is the use of antidepressants in Bipolar I Depression). Take a look at this quote from Dr. Birx around the time the task force was rolled out: So I know that she is highly trained and I am sure she understands levels of evidence, but WTF? I have always hoped she was pressured into saying that, or that she just worded her sentence poorly and meant something else. Argumentum ad populem is a BS political tactic and should never be amplified by medical experts.
  6. Ya know, I enjoyed the hell out of Reggie McNeal lighting up OU for 4 TDs, despite the fact that I can't stand the dude and that lame ass program that he played for. But I have no regrets enjoying the hell out of it.
  7. Did they use the Fisher's exact test? There's always something fishy about stories like this where they get the test bass ackwards.
  8. Excellent name for the band that plays at his campaign events.
  9. You know the fucked up thing about this situation is not that your statements are true (they are), but that the TEA fucking admits it in their Planning Guidance document released on July 7, 2020: Oh, OK. Mitigation is the key, right? So...one of the few things we know about this virus is that the people who are spreading it the most are the asymptomatic ones. So how the fuck is this mitigation strategy going to work? Last I checked, most schools don't have a tricked-out, plutonium-fueled DeLorean to go back in time and remove the super spreaders from the rest of the kids. Am I over-reacting? I want my son to be in a classroom again, and he wants it more than I do, but neither of us want him there until we feel it is safe. For everyone.
  10. I wish I could remember where I saw some video report on the guy showing up to Comet (the location of Pizzagate), but at least here's a Tweet about it back when the news broke:
  11. I found this one to be fascinating. It should be a satisfactory primer. https://jurneywrites.wordpress.com/2020/04/17/pizzagate-and-the-research-that-nobody-wanted-to-do/
  12. He's a war hero and Sharon Stone's cousin. He can't lose.
  13. I remember when that pissant Dotard acolyte was interviewed when he tauted his own ability to understand the data better than Fauci. I will never suffer from hypotensive episodes as long as jerk off sycophants like this are running our country into the ground, it just shoots my blood pressure up higher than the DJIA on a day when record unemployment numbers are released. https://www.cnn.com/2020/04/06/opinions/peter-navarro-anthony-fauci-hydroxychloroquine-expertise-hemmer/index.html
  14. See, this type of human excrement is an example of how political hacks could cause a massive amount of unnecessary deaths/disability/human suffering. The assholes like this bitch that have cultivated the suspicion that vaccines are harmful were the reason that once "eradicated" diseases like smallpox made a comeback. Fuck her and the herd she eroded in on.
  15. "But I thought there was only one peak, sir." "Well, that'll save a bit of time. Well done. Now the object of this expedition is to see if we can find any traces of last year's expedition."
  16. Yes, that was the first thing I thought when I clicked the link (sorry I forgot to mention that). So I looked at the name and title of the investigator that was mentioned (Prof. Sara Gilbert) and found this website: https://www.ovg.ox.ac.uk/news/covid-19-vaccine-development Here is an excerpt, which led me to believe their work is legit, but I'd like to see the data and methods of the results that led to their claim that was the focus of the article (hence my cautious optimism): Scientists around the world are working hard to develop a vaccine to prevent COVID-19, but there is a lot to be done. A team in Oxford led by Prof. Sarah Gilbert, Prof. Andrew Pollard, Prof. Teresa Lambe, Dr Sandy Douglas and Prof. Adrian Hill started work designing a vaccine on Saturday 10th January 2020. The current status is that they have identified a vaccine candidate and are working towards the first clinical testing phase. A chimpanzee adenovirus vaccine vector (ChAdOx1), developed at Oxford’s Jenner Institute, was chosen as the most suitable vaccine technology for a SARS-CoV-2 vaccine as it can generate a strong immune response from one dose and it is not a replicating virus, so it cannot cause an ongoing infection in the vaccinated individual. This also makes it safer to give to children, the elderly and anyone with a pre-existing condition such as diabetes. Chimpanzee adenoviral vectors are a very well-studied vaccine type, having been used safely in thousands of subjects, from 1 week to 90 years of age, in vaccines targeting over 10 different diseases. Coronaviruses have club-shaped spikes on their outer coats. Immune responses from other coronavirus studies suggest that these are a good target for a vaccine. The Oxford vaccine contains the genetic sequence of this surface spike protein inside the ChAdOx1 construct. After vaccination, the surface spike protein of the coronavirus is produced, which primes the immune system to attack the coronavirus if it later infects the body. Prof. Gilbert and team have previously developed a vaccine for another human coronavirus disease, which is Middle East Respiratory Syndrome (MERS), and this has shown promise in early clinical trials. At the same time as preparing for and conducting the first clinical trial, production of the vaccine is being scaled up ready for larger trials, and potentially, future deployment. Researchers at Oxford University are working with great care, and due haste, in developing a new vaccine for coronavirus. Production is underway and we are recruiting for a clinical trial. If proven effective, a safe coronavirus vaccine could provide an exit strategy for the pandemic and save lives. While we understand the interest, we ask that the media do not continue to contact researchers while this critical work is underway so that they can focus on these efforts. We will issue press releases in due course.
  17. Would love to see a modern day remake of Python's Upper Class Twit of the Year sketch with those guys competing. Instead of shooting themselves they could infect themselves with covid. Herman Cain could root them on from his hospital bed.
  18. Seems like a legit group but I'd like to see their data, methods, etc. Call me cautiously optimistic that their approach will be successful.
  19. https://gov.texas.gov/news/post/governor-abbott-establishes-statewide-face-covering-requirement-issues-proclamation-to-limit-gatherings Governor Abbott Establishes Statewide Face Covering Requirement, Issues Proclamation To Limit Gatherings July 2, 2020 | Austin, Texas | Press Release Governor Greg Abbott today issued an Executive Order requiring all Texans to wear a face covering over the nose and mouth in public spaces in counties with 20 or more positive COVID-19 cases, with few exceptions. The Governor also issued a proclamation giving mayors and county judges the ability to impose restrictions on some outdoor gatherings of over 10 people, and making it mandatory that, with certain exceptions, people cannot be in groups larger than ten and must maintain six feet of social distancing from others. "Wearing a face covering in public is proven to be one of the most effective ways we have to slow the spread of COVID-19,” said Governor Abbott. “We have the ability to keep businesses open and move our economy forward so that Texans can continue to earn a paycheck, but it requires each of us to do our part to protect one another—and that means wearing a face covering in public spaces. Likewise, large gatherings are a clear contributor to the rise in COVID-19 cases. Restricting the size of groups gatherings will strengthen Texas’ ability to corral this virus and keep Texans safe. We all have a responsibility to slow the spread of COVID-19 and keep our communities safe. If Texans commit to wearing face coverings in public spaces and follow the best health and safety practices, we can both slow the spread of COVID-19 and keep Texas open for business. I urge all Texans to wear a face covering in public, not just for their own health, but for the health of their families, friends, and for all our fellow Texans.” Additionally, the Governor released a new video message to coincide with his Executive Order, encouraging Texans to do their part to mitigate the spread of COVID-19 and keep their communities safe. The video can be downloaded at this linkand can also be viewed on YouTube. View the Governor's Executive Order. View the Governor's Proclamation. Home
  20. You can say that again. Wait, what does that mean? Maybe they meant irrelevant because LOL at thought of them making an NY6 bowl?
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