Bevo

Oh, kind of like Joe Burrow and Quinn Ewers.

Fuck that. Let me know when Swift and Kelce go.

Would you really hold that against her?

Generics don’t make the largest companies profitable. In fact, I don’t know where things stand now, but 20 years ago, most pharmaceutical companies divested their OTC products and generics were an insignificant portion of sales. Basically all of their profits come from patented products and pharmaceutical companies attempt numerous workarounds to try to extend their patents as long as possible. Some of that has changed more recently due to the difficulty for companies to get generic biologics approved by the FDA, but still pharmaceutical companies don’t care about their generic products. All pharmaceutical profits are derived from innovation whether new targets or simply improved side effect profiles, method of delivery, etc. Anyway, it stands to reason that pharmaceutical companies strive to keep their product pipelines full. So, what do you think would happen if the industry were less profitable, had PEs similar to commodities, and earned exactly what the government thought was their right to earn? First, we would see good things - smaller sales forces, lower drug prices, less advertising. But later we would also see more mergers and acquisitions as the industry continued to mature. And we would see a decrease in development as the return on investment would justify fewer innovative, riskier products. Does this mean that innovation would die? Of course not. It would only slow down initially. However, in this scenario where government controls pharmaceutical prices, what happens as the government still has shortfalls in what it has budgeted to pay for pharmaceuticals? Well of course it would lower pharmaceutical prices even more. At some point without profits, development of pharmaceuticals comes to a crawl verses the rapid innovations that have occurred since penicillin was commercialized during WW2.

My guess is that he led with NIL demands.

Oregon and tOSU will be a battle. They should have the exact same chance to win it all. PSU will advance. We will advance. Georgia and Notre Dame will be a battle. Then it will be PSU vs the winner of the GA vs ND. And us vs the winner of OR vs OSU. PSU will lose because they aren't that good. And our game will be a tossup.

Like alligator tackling?

In conference play, we beat Mississippi State, OU, and Florida by a lot, Kentucky was somewhere in the middle, and A&M, Vanderbilt, and Arkansas we kept in the game through dumbassery. This is an away game against an opponent who would be middle of the pack in the SEC. It's possible that we could blow them out, but I think it is more likely that we will gift points and keep them in it similar to how the Clemson game went.

Yeah, unfortunately this year Sark and our QB have a penchant for close games. Whether it is a timely interception, a poor coaching decision, a costly penalty, or a fumble, we have notoriously kept lesser teams feeling like they have a chance. We totally dominated Clemson and could have easily been up by 21+ points and forced them to panic or lay down, but that didn't happen. And it hasn't happened all season. I guess this time could be different, but I won't count on it. We will win, but I can't remember our last blowout victory.

Closest I could find but no numbers: Ukraine Gets Major $266 Million F-16 Boost From US Published Dec 11, 2024 at 5:42 AM EST Updated Dec 12, 2024 at 11:33 AM EST Ukraine Approves New Droid Fighter Robot With Mounted Machine Gun By Hugh Cameron The U.S. has authorized a $266 million military package for Ukraine, aimed at supporting the services and repairs required to maintain the country's fleet of F-16 fighter jets. The announcement came on Tuesday from the U.S. Defense Security Cooperation Agency (DSCA), a branch of the Defense Department focused on weapons transfers and related support to allied nations. In its release, the DSCA said the State Department had approved the quarter-billion-dollar support package and Congress had been notified of the proposed sale, which when finalized will comprise "sustainment services and related equipment" for Kyiv's fighter jets. These include the Joint Mission Planning System, a software-based tool used by the Defense Department to coordinate missions for military aircraft and other assets, as well as maintenance services, personnel training and spare parts. "This proposed sale will support the foreign policy goals and national security objectives of the United States by improving the security of a partner country that is a force for political stability and economic progress in Europe," the DSCA said. It added that the sale will "improve Ukraine's capability to meet current and future threats by further equipping it to conduct self-defense and regional security missions with a more robust air defense capability" and that the country "will have no difficulty absorbing these articles and services into its armed forces." F-16 A Danish F-16 at the Farnborough International Airshow 2024, U.K. On Tuesday, the U.S. DSCA announced the approval of a $266 million military package for Ukrainian F-16s. John Keeble/Getty Images As well as facilitating the transfer of the jets to Ukraine from European nations, the U.S. has in the past helped to upgrade Kyiv's existing fleet. In late August, the U.S. Department of Defense's Defense Visual Information Distribution Service announced that jets supplied by the Netherlands and Denmark had been fitted with new systems allowing them to conduct "full-spectrum electromagnetic warfare." "The F-16s are operational and actively participating in Ukraine's combat operations," a State Department official told Newsweek. "The United States, along with its allies and partners, remains committed to supporting the expansion of Ukraine's F-16 program, which includes increasing the number of aircraft, as well as training pilots and maintainers." Ukraine announced that it had received its first batch of American-made F-16 fighter jets, originally developed for the U.S. Air Force, in August. Ukrainian President Volodymyr Zelensky expressed gratitude to the U.S., Denmark and the Netherlands for their support but did not specify which country supplied the shipment. Read more Ukraine Ukraine's NATO allies—including Denmark, the Netherlands, Norway and Belgium—have together promised to send nearly 100 F-16s to Kyiv, according to FlightGlobal, though it is unclear how many have been received or are yet operational. However, this sum is still insufficient, according to Ukraine. Zelensky told AFP in May that his country would require "120 to 130" F-16s to achieve "parity" with Russia's forces. When contacted for further information, a State Department official told Newsweek that they were unable to disclose the exact number of F-16s currently in Ukraine "for operational security reasons." On December 7, Zelensky said his country had received its second shipment of F-16s from Denmark, describing this as "an example of leadership in defending lives that sets Denmark apart." "The aircraft from the first batch, provided by the Danish people, are already intercepting Russian missiles, saving our people's lives and our infrastructure," Zelensky posted to X. "Now, our air shield has been further strengthened. If all partners were as determined, Russian terror could already have been made impossible."

How many jets have been delivered to Ukraine? I heard lots of announcements when countries offered them.

Ding ding ding. For the most part, research stops at research. As @TwiceHorn would attest, that doesn't help consumers. Ideas need to be developed and then commercialized. Those commercialized products are what we consume. There are tons of good ideas out there. Only the few that are well-funded, developed, and commercialized make it to market.

Wrong, but I worked in the biotech industry for 15 years in licensing, business development, marketing management and consulting. So, I have enough experience to be considered an expert in university technology transfer, basic research, biotech companies, pharmaceutical companies and immunohistochemistry diagnostic companies (not much experience in medical equipment). And now I have 15 years of experience in patient care. Just since we are discussing the issue, besides being a consumer, what is your experience?

Have you been watching this season?

Also, we have a pretty big alumni base in Atlanta. The Mellow Mushroom would always have a big game watching party.

@NowThis can give you some pointers.

Yeah, but what does he remember?

Did we win?

And they kind of screw the developing universities. Univ. of Minnesota, University of Wisconsin and the Medical College of Wisconsin together pretty much invented modern MRI machines. GE, Siemens, and Toshiba license some of the tech and steal some of the tech and none of them enforce the patents. More important, GE throws some money to the researchers and the researchers keep the university from enforcing the patents.

Over the weekend, a savage massacre in Port-au-Prince, Haiti, resulted in at least 184 deaths, highlighting the escalating instability in a nation already beset by rampant gang violence for several years. According to reports, the murders targeted elderly inhabitants in the Cité Soleil district and were allegedly commanded by Monel “Mikano” Felix, the Wharf Jérémie gang’s leader. The National Human Rights Defense Network (RNDDH) reports that Felix sought advice from a voodoo priest when his child fell ill and eventually died on Saturday. The priest allegedly pinned the blame on the senior citizens in the area, accusing them of witchcraft. As per the RNDDH, “Felix ordered the killings, and at least 110 people aged 60 and older were slaughtered over the weekend, many with machetes and knives.”

Archie Manning - Red Zone replacement.

Or another way to look at it is that the US consumer pays for the world's medical advances.

A 6 Tesla MRI machine is up to $7M and a stent can cost up to $5000ea and an anesthesia workstation is probably $40K and a home dialysis machine is $45K. But the simple stuff like sutures aren't that cheap either.

We are talking recent history, right? Because sure you could talk about Louis Pasteur and the Pasteur Institute, but that was many years ago. Now we are talking about multinational companies with headquarters in places like Basel and London and Paris and New York. But if you look at the revenue of any of them, half their worldwide revenue comes from the US. And that equates to about 80% of their profits. And the biotech industry is even more US centric. University research is a little more diverse, but NIH funding pretty much dwarfs research funding from other countries at $45 billion. So yeah, the development of the worlds' medical advances are mainly derived from the US. Perhaps you should do some research before arguing with medical experts. Jesus, the arrogance of some attorneys is breathtaking.

Profits in the pharmaceutical and medical device industries leads to patient well-being. Without money, there is some research but there is no development and no commercialization.