that would be nice but the real explanation is far more boring unfortunately.
it is entirely a function of different wavelengths of light and what scatters light at each wavelength. you'll notice that in the optical image from hst (which is optical), there does not appear to be a hole but instead light, (blueish colored) non-dense dust and gasses. in jwst, it looks like it is just an empty hole of space. that is because jwst is capturing the infrared wavelength instead of optical. infrared is a longer wavelength than the visible light from hst and passes through denser regions of space than optical without the light scattering...meaning it looks like nothing is there. so the distant high energy infrared light sources appear to just pass through the gas/dust untouched through a hole even thought it isn't really a hole. it's just a non-dense area of dust/gas and matter in that portion of the galaxy in which the infrared just passes right through without scattering. you see the same thing in the top right of the image.
a terrible, but easily understood analogy would be imagine everything in the left picture is skin. that's what we see when we look at it with our eyes. now imagine everything on the right is bones. when we look at it in x-ray wave lengths, it looks like the skin goes away and all that is left is bones. sure, there was non-dense skin that doesn't scatter x-ray light there, but there are no bones either so it looks like a big hole in the image. why there is such a drastic change in density there is simply a function of the governing dynamics of galactic formation.