The "Dave Chappelle is just an edgy comedian doing edgy comedian things" defense is wrong, IMO.
DC is the closest thing we have to a mainstream public intellectual, at this point.
He is extremely intentional and thoughtful and communicative-- he has an obvious gift that has transcended comedy in the later years. Watch any of this publicly accessible stuff from 8:46 to the Netflix Redemption song two parts. It's a master class in not only story telling but also communicating directly with the audience and cutting out the middle man. There is a whole huge write-up I'll find and share about how he handled the Netflix situation which was awesome.
That being said, I find it hard to believe that DC doesn't harbor at least a bit of personal animus towards the Trans community. Like others have said, he should just own it with a "I said what I said", like JK Rowling before him, because there is, or at least should be, room for interpretation and beliefs about basic things like gender and other social constructs. And he should take on the chin whatever comes his way for saying what he says.
But like others have mentioned, DC is smart enough to spout off after gaining credibility in his ability to think and form opinions, as well as having a huge platform and popularity that insulates him from being "cancelled". If he were just a guy having done Def Jam VHS specials and a bit (albeit funny) part on the Nutty Professor, he would be sunk.