https://www.nytimes.com/2021/04/13/us/politics/johnson-johnson-vaccine-blood-clots-fda-cdc.html#click=https://t.co/NkjtHukwHQ
Shit. Not good. A major mistake IMO
I guess it’s time for ol HemeDoc to weigh in vis a vis the clotting and platelet issues surrounding the AZ vaccine and now maybe J&J...so let me wave something shiny in front of you monkeys.
The AZ vaccine has reported a rare form of blood clots plus low platelets. ~60% involve veins of brain. Almost all after 1st dose.
Risk from the UK is about 1 in 250,000 people
Risk of dying: 20-25% of people with these clots have died
Approximately half of the deaths in the UK (11 of 19) were under age 50.
The benefits of the AZ vaccine according to regulators appear to outweigh risks in all except those less than age 30.
While blood clots occur at a certain rate in population what is unusual about these clots is the association with low platelets. Platelets help make blood clots & when platelets are low we are at risk of bleeding not clotting.
Low platelets in context of blood clots is unusual. This type of combination of low platelets and blood clots occurs in patients exposed to heparin (HIT). It can also occur with hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, and sometimes with antiphospholipid antibody syndrome.
Emerging data suggest that the mechanism of the clots may involve antibodies generated (presumably by the vaccine - most likely the adenovirus vector) that target platelet factor 4 (PF4), similar to the process that happens in some people after exposure to heparin (HIT)