Formerly DT: COVID-19 - Featuring Lots of Politics, now CR because political talk not going away

[Sandman 3403]

About 5 years or so ago, I tried to get my office to move into the 21st century and move most of our processes online. Yeah, my main goal was to try to work from home but my point was valid, our shit is incredibly outdated. Nobody wanted to hear it, everything was fine, it would be a disaster to change anything. Now they're scrambling to figure out how to get shit done remotely. We had the $$$ to implement this plan and nobody could be bothered to do anything. They always seem to figure this shit out after it's too late. 

[Mrs Whiggins 13050]

5 minutes ago, SydneyCarton said:

 

It has to be incredibly frustrating position to be in right now--good daycare is already a scarce commodity, and I don't want to CR in here about the policies that make things worse but employers need to loosen up right now and let their employees find workable solutions. It may take some time to work out, but I believe most parents are doing their best.

I'm waiting for some one to pose the idea that parents drop off their children at the park where each child is tethered to a peg with a six foot radius given how little compassion for working parents there has been.

Be nice to each other, each day each hour.

[NotActuallyALonghorn 4976]

22 minutes ago, CleverNickname said:

Literally in the Basin right now. Park is effectively in government shut down. No visitors centers. Little store is open, but they have a cap on number inside.  Basin restaurant is basically take out only plusbthe 4 outside tables. We've eaten 100% of our food from our own stores. I saw only 1 other truck in the state park yesterday. Today may be a little busier - grapevine hills and walking tornillo creek. 

Man, they tightened up quickly. We left Monday afternoon and everything seemed like business as usual.

[Nice Guy Eddie 13510]

19 minutes ago, horncyclist said:

I wouldn't be surprised if this brings the Iranian regime down.

At some point, when govts fail to govern, they cease to exist.

[GabrielsHorn 2183]

1 hour ago, tantric superman said:

Word to the wise:  If you get a chance to listen to an interview with Gov. Cuomo, don't. 

Guy is pretty grim.

On the other hand, Fauci came on Pardon My Take, and he did a pretty good job of not being so grim while being serious about it.

[NoName 16351]

talk about out of touch...

The Verge: Medical company threatens to sue volunteers that 3D-printed valves for life-saving coronavirus treatments

Quote

 

A medical device manufacturer has threatened to sue a group of volunteers in Italy that 3D printed a valve used for life-saving coronavirus treatments. The valve typically costs about $11,000 from the medical device manufacturer, but the volunteers were able to print replicas for about $1 (via Techdirt).

A hospital in Italy was in need of the valves after running out while treating patients for COVID-19. The hospital’s usual supplier said they could not make the valves in time to treat the patients, according to Metro. That launched a search for a way to 3D print a replica part, and Cristian Fracassi and Alessandro Ramaioli, who work at Italian startup Isinnova, offered their company’s printer for the job, reports Business Insider.

However, when the pair asked the manufacturer of the valves for blueprints they could use to print replicas, the company declined and threatened to sue for patent infringement, according to Business Insider Italia. Fracassi and Ramaioli moved ahead anyway by measuring the valves and 3D printing three different versions of them.

 

Quote

“[The patients] were people in danger of life, and we acted. Period,” said Fracassi in a Facebook post. He also said that “we have no intention of profit on this situation, we are not going to use the designs or product beyond the strict need for us forced to act, we are not going to spread the drawing.”

Full Text:

Spoiler

 

Medical company threatens to sue volunteers that 3D-printed valves for life-saving coronavirus treatments
39
The valve typically costs about $11,000 — the volunteers made them for about $1

By Jay Peters@jaypeters  Mar 17, 2020, 5:51pm CDT
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Image: Massimo Temporelli
A medical device manufacturer has threatened to sue a group of volunteers in Italy that 3D printed a valve used for life-saving coronavirus treatments. The valve typically costs about $11,000 from the medical device manufacturer, but the volunteers were able to print replicas for about $1 (via Techdirt).

A hospital in Italy was in need of the valves after running out while treating patients for COVID-19. The hospital’s usual supplier said they could not make the valves in time to treat the patients, according to Metro. That launched a search for a way to 3D print a replica part, and Cristian Fracassi and Alessandro Ramaioli, who work at Italian startup Isinnova, offered their company’s printer for the job, reports Business Insider.

However, when the pair asked the manufacturer of the valves for blueprints they could use to print replicas, the company declined and threatened to sue for patent infringement, according to Business Insider Italia. Fracassi and Ramaioli moved ahead anyway by measuring the valves and 3D printing three different versions of them.

 
The new coronavirus is spreading through the US, and several states have made emergency declarations. The World Health Organization has declared it a pandemic. Here are the basics:

EVERYTHING YOU NEED TO KNOW ABOUT THE CORONAVIRUS
So far, the valves they made have worked on 10 patients as of March 14th, according to Massimo Temporelli, the founder of Italian manufacturing solutions company FabLab who helped recruit Fracassi and Ramaioli to print the replica valves.

“[The patients] were people in danger of life, and we acted. Period,” said Fracassi in a Facebook post. He also said that “we have no intention of profit on this situation, we are not going to use the designs or product beyond the strict need for us forced to act, we are not going to spread the drawing.”

Here’s a good look at the valves, shared by Italy’s Minister of Technological Innovation Paola Pisano on Twitter.

 

Italy has more than 31,500 confirmed infections of COVID-19, the disease caused by the novel coronavirus, and more than 2,500 confirmed deaths. Both figures trail only China.

 

 

[Js1 85311]

9 minutes ago, Sandman said:

About 5 years or so ago, I tried to get my office to move into the 21st century and move most of our processes online. Yeah, my main goal was to try to work from home but my point was valid, our shit is incredibly outdated. Nobody wanted to hear it, everything was fine, it would be a disaster to change anything. Now they're scrambling to figure out how to get shit done remotely. We had the $$$ to implement this plan and nobody could be bothered to do anything. They always seem to figure this shit out after it's too late. 

Similar-ish. Turns out not only is this rotational staffing plan for COVID-19, it’s also a test program for working remote 3 days a week. 

Some good may come of this. 

[Captainant 27654]

1 minute ago, NoName said:

talk about out of touch...

The Verge: Medical company threatens to sue volunteers that 3D-printed valves for life-saving coronavirus treatments

Full Text:

  Reveal hidden contents

 

Medical company threatens to sue volunteers that 3D-printed valves for life-saving coronavirus treatments
39
The valve typically costs about $11,000 — the volunteers made them for about $1

By Jay Peters@jaypeters  Mar 17, 2020, 5:51pm CDT
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Image: Massimo Temporelli
A medical device manufacturer has threatened to sue a group of volunteers in Italy that 3D printed a valve used for life-saving coronavirus treatments. The valve typically costs about $11,000 from the medical device manufacturer, but the volunteers were able to print replicas for about $1 (via Techdirt).

A hospital in Italy was in need of the valves after running out while treating patients for COVID-19. The hospital’s usual supplier said they could not make the valves in time to treat the patients, according to Metro. That launched a search for a way to 3D print a replica part, and Cristian Fracassi and Alessandro Ramaioli, who work at Italian startup Isinnova, offered their company’s printer for the job, reports Business Insider.

However, when the pair asked the manufacturer of the valves for blueprints they could use to print replicas, the company declined and threatened to sue for patent infringement, according to Business Insider Italia. Fracassi and Ramaioli moved ahead anyway by measuring the valves and 3D printing three different versions of them.

 
The new coronavirus is spreading through the US, and several states have made emergency declarations. The World Health Organization has declared it a pandemic. Here are the basics:

EVERYTHING YOU NEED TO KNOW ABOUT THE CORONAVIRUS
So far, the valves they made have worked on 10 patients as of March 14th, according to Massimo Temporelli, the founder of Italian manufacturing solutions company FabLab who helped recruit Fracassi and Ramaioli to print the replica valves.

“[The patients] were people in danger of life, and we acted. Period,” said Fracassi in a Facebook post. He also said that “we have no intention of profit on this situation, we are not going to use the designs or product beyond the strict need for us forced to act, we are not going to spread the drawing.”

Here’s a good look at the valves, shared by Italy’s Minister of Technological Innovation Paola Pisano on Twitter.

 

Italy has more than 31,500 confirmed infections of COVID-19, the disease caused by the novel coronavirus, and more than 2,500 confirmed deaths. Both figures trail only China.

 

 

For profit healthcare institution (the IP holder) putting their profits above the health outcomes of their patients?? I don't believe it!

[Chewy's Hairy Horn 868]

24 minutes ago, NoName said:

this is also relevant to discussions in prior pages

text below

  Reveal hidden contents

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1
March 17, 2020
DOI: 10.1056/NEJMc2004973
Metrics 

TO THE EDITOR:
A novel human coronavirus that is now named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (formerly called HCoV-19) emerged in Wuhan, China, in late 2019 and is now causing a pandemic.1 We analyzed the aerosol and surface stability of SARS-CoV-2 and compared it with SARS-CoV-1, the most closely related human coronavirus.2

We evaluated the stability of SARS-CoV-2 and SARS-CoV-1 in aerosols and on various surfaces and estimated their decay rates using a Bayesian regression model (see the Methods section in the Supplementary Appendix, available with the full text of this letter at NEJM.org). SARS-CoV-2 nCoV-WA1-2020 (MN985325.1) and SARS-CoV-1 Tor2 (AY274119.3) were the strains used. Aerosols (<5 μm) containing SARS-CoV-2 (105.25 50% tissue-culture infectious dose [TCID50] per milliliter) or SARS-CoV-1 (106.75-7.00 TCID50 per milliliter) were generated with the use of a three-jet Collison nebulizer and fed into a Goldberg drum to create an aerosolized environment. The inoculum resulted in cycle-threshold values between 20 and 22, similar to those observed in samples obtained from the upper and lower respiratory tract in humans.

Our data consisted of 10 experimental conditions involving two viruses (SARS-CoV-2 and SARS-CoV-1) in five environmental conditions (aerosols, plastic, stainless steel, copper, and cardboard). All experimental measurements are reported as means across three replicates.

Figure 1.

Viability of SARS-CoV-1 and SARS-CoV-2 in Aerosols and on Various Surfaces.
SARS-CoV-2 remained viable in aerosols throughout the duration of our experiment (3 hours), with a reduction in infectious titer from 103.5 to 102.7 TCID50 per liter of air. This reduction was similar to that observed with SARS-CoV-1, from 104.3 to 103.5 TCID50 per milliliter (Figure 1A).

SARS-CoV-2 was more stable on plastic and stainless steel than on copper and cardboard, and viable virus was detected up to 72 hours after application to these surfaces (Figure 1A), although the virus titer was greatly reduced (from 103.7 to 100.6 TCID50 per milliliter of medium after 72 hours on plastic and from 103.7 to 100.6 TCID50 per milliliter after 48 hours on stainless steel). The stability kinetics of SARS-CoV-1 were similar (from 103.4 to 100.7 TCID50 per milliliter after 72 hours on plastic and from 103.6 to 100.6 TCID50 per milliliter after 48 hours on stainless steel). On copper, no viable SARS-CoV-2 was measured after 4 hours and no viable SARS-CoV-1 was measured after 8 hours. On cardboard, no viable SARS-CoV-2 was measured after 24 hours and no viable SARS-CoV-1 was measured after 8 hours (Figure 1A).

Both viruses had an exponential decay in virus titer across all experimental conditions, as indicated by a linear decrease in the log10TCID50 per liter of air or milliliter of medium over time (Figure 1B). The half-lives of SARS-CoV-2 and SARS-CoV-1 were similar in aerosols, with median estimates of approximately 1.1 to 1.2 hours and 95% credible intervals of 0.64 to 2.64 for SARS-CoV-2 and 0.78 to 2.43 for SARS-CoV-1 (Figure 1C, and Table S1 in the Supplementary Appendix). The half-lives of the two viruses were also similar on copper. On cardboard, the half-life of SARS-CoV-2 was longer than that of SARS-CoV-1. The longest viability of both viruses was on stainless steel and plastic; the estimated median half-life of SARS-CoV-2 was approximately 5.6 hours on stainless steel and 6.8 hours on plastic (Figure 1C). Estimated differences in the half-lives of the two viruses were small except for those on cardboard (Figure 1C). Individual replicate data were noticeably “noisier” (i.e., there was more variation in the experiment, resulting in a larger standard error) for cardboard than for other surfaces (Fig. S1 through S5), so we advise caution in interpreting this result.

We found that the stability of SARS-CoV-2 was similar to that of SARS-CoV-1 under the experimental circumstances tested. This indicates that differences in the epidemiologic characteristics of these viruses probably arise from other factors, including high viral loads in the upper respiratory tract and the potential for persons infected with SARS-CoV-2 to shed and transmit the virus while asymptomatic.3,4 Our results indicate that aerosol and fomite transmission of SARS-CoV-2 is plausible, since the virus can remain viable and infectious in aerosols for hours and on surfaces up to days (depending on the inoculum shed). These findings echo those with SARS-CoV-1, in which these forms of transmission were associated with nosocomial spread and super-spreading events,5 and they provide information for pandemic mitigation efforts.

Neeltje van Doremalen, Ph.D.
Trenton Bushmaker, B.Sc.
National Institute of Allergy and Infectious Diseases, Hamilton, MT

Dylan H. Morris, M.Phil.
Princeton University, Princeton, NJ

Myndi G. Holbrook, B.Sc.
National Institute of Allergy and Infectious Diseases, Hamilton, MT

Amandine Gamble, Ph.D.
University of California, Los Angeles, Los Angeles, CA

Brandi N. Williamson, M.P.H.
National Institute of Allergy and Infectious Diseases, Hamilton, MT

Azaibi Tamin, Ph.D.
Jennifer L. Harcourt, Ph.D.
Natalie J. Thornburg, Ph.D.
Susan I. Gerber, M.D.
Centers for Disease Control and Prevention, Atlanta, GA

James O. Lloyd-Smith, Ph.D.
University of California, Los Angeles, Los Angeles, CA, Bethesda, MD

Emmie de Wit, Ph.D.
Vincent J. Munster, Ph.D.
National Institute of Allergy and Infectious Diseases, Hamilton, MT 
vincent.munster@nih.gov

Supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and by contracts from the Defense Advanced Research Projects Agency (DARPA PREEMPT No. D18AC00031, to Drs. Lloyd-Smith and Gamble), from the National Science Foundation (DEB-1557022, to Dr. Lloyd-Smith), and from the Strategic Environmental Research and Development Program of the Department of Defense (SERDP, RC-2635, to Dr. Lloyd-Smith).

Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.

The findings and conclusions in this letter are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention (CDC). Names of specific vendors, manufacturers, or products are included for public health and informational purposes; inclusion does not imply endorsement of the vendors, manufacturers, or products by the CDC or the Department of Health and Human Services.

This letter was published on March 17, 2020, at NEJM.org.

Dr. van Doremalen, Mr. Bushmaker, and Mr. Morris contributed equally to this letter.

 

 

 

plastic and steel: viable virus after 72 hours

copper: no viable virus 8 hours 

cardboard: no viable virus after 24 hours

...and how about granite or stone?

[Anastasis 23469]

1 hour ago, BradInATX said:

For those asking the day care question, we pulled our son out as of yesterday (his last day prior to that was last Friday). But it was a very tough decision, and our family situation is very, very conducive to making it work. Do what works for your family. Our day care admin said that more than half of families are still enrolled. 

Day care should be reserved for children of front lines medical personnel and those with no other options. 

[ChickenSandwich 9832]

6 hours ago, Hate said:

This is 100% correct and something I've been espousing since the early days of this pandemic. The Chinese probably knew this was an issue by mid November or so.  Fuck them.  They need to feel the pain the rest of the world will feel from this. We need to re-patriot as much of our manufacturing as we possibly can and what can't be brought back to the US should go to Mexico, Central and South America.  Fuck China!

We also need to re-evaluate population density. The problems way out pace any potential benefits. Use our resources and innovation to use one of our biggest resources. Land. 
 

Stop trying to find solutions to cram every individual into the same shoebox and use those resources to better connect communities. A dollar spent to solve transportation issues benefits exponentially more individuals than that same dollar spent on forced housing in overcrowded cities. 
 

Space is a strength. Maximize resources. Fuck density. 

Edited March 18, 2020 by ChickenSandwich

[Anastasis 23469]

7 minutes ago, NoName said:

talk about out of touch...

The Verge: Medical company threatens to sue volunteers that 3D-printed valves for life-saving coronavirus treatments

Full Text:

  Reveal hidden contents

 

Medical company threatens to sue volunteers that 3D-printed valves for life-saving coronavirus treatments
39
The valve typically costs about $11,000 — the volunteers made them for about $1

By Jay Peters@jaypeters  Mar 17, 2020, 5:51pm CDT
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Image: Massimo Temporelli
A medical device manufacturer has threatened to sue a group of volunteers in Italy that 3D printed a valve used for life-saving coronavirus treatments. The valve typically costs about $11,000 from the medical device manufacturer, but the volunteers were able to print replicas for about $1 (via Techdirt).

A hospital in Italy was in need of the valves after running out while treating patients for COVID-19. The hospital’s usual supplier said they could not make the valves in time to treat the patients, according to Metro. That launched a search for a way to 3D print a replica part, and Cristian Fracassi and Alessandro Ramaioli, who work at Italian startup Isinnova, offered their company’s printer for the job, reports Business Insider.

However, when the pair asked the manufacturer of the valves for blueprints they could use to print replicas, the company declined and threatened to sue for patent infringement, according to Business Insider Italia. Fracassi and Ramaioli moved ahead anyway by measuring the valves and 3D printing three different versions of them.

 
The new coronavirus is spreading through the US, and several states have made emergency declarations. The World Health Organization has declared it a pandemic. Here are the basics:

EVERYTHING YOU NEED TO KNOW ABOUT THE CORONAVIRUS
So far, the valves they made have worked on 10 patients as of March 14th, according to Massimo Temporelli, the founder of Italian manufacturing solutions company FabLab who helped recruit Fracassi and Ramaioli to print the replica valves.

“[The patients] were people in danger of life, and we acted. Period,” said Fracassi in a Facebook post. He also said that “we have no intention of profit on this situation, we are not going to use the designs or product beyond the strict need for us forced to act, we are not going to spread the drawing.”

Here’s a good look at the valves, shared by Italy’s Minister of Technological Innovation Paola Pisano on Twitter.

 

Italy has more than 31,500 confirmed infections of COVID-19, the disease caused by the novel coronavirus, and more than 2,500 confirmed deaths. Both figures trail only China.

 

 

They should fuck off and go to hell. 

[NoName 16351]

1 minute ago, Chewy's Hairy Horn said:

...and how about granite or stone?

Quote

This new report shows the stability of the virus in aerosols, plastic, stainless steel, copper, and cardboard and estimate their decay rates over time.

 

[JOSEYWALES66 1801]

17 minutes ago, Sandman said:

About 5 years or so ago, I tried to get my office to move into the 21st century and move most of our processes online. Yeah, my main goal was to try to work from home but my point was valid, our shit is incredibly outdated. Nobody wanted to hear it, everything was fine, it would be a disaster to change anything. Now they're scrambling to figure out how to get shit done remotely. We had the $$$ to implement this plan and nobody could be bothered to do anything. They always seem to figure this shit out after it's too late. 

Around that same time we had a third party evaluate our disaster recovery procedures and they found them severely lacking. Based on their recommendations we instituted a major upgrade and now everyone that can is working from home.   IT and management who supported them deserve a lot of credit.  

[MissingInAction 25037]

20 minutes ago, Sandman said:

About 5 years or so ago, I tried to get my office to move into the 21st century and move most of our processes online. Yeah, my main goal was to try to work from home but my point was valid, our shit is incredibly outdated. Nobody wanted to hear it, everything was fine, it would be a disaster to change anything. Now they're scrambling to figure out how to get shit done remotely. We had the $$$ to implement this plan and nobody could be bothered to do anything. They always seem to figure this shit out after it's too late. 

Do you work for the public sector? Because that describes exactly what is happening in my environment now. I am a senior IT support employee and I JUST got a laptop so I can help people from home. 

[riloh05 107]

12 minutes ago, NoName said:

talk about out of touch...

The Verge: Medical company threatens to sue volunteers that 3D-printed valves for life-saving coronavirus treatments

Full Text:

  Reveal hidden contents

 

Medical company threatens to sue volunteers that 3D-printed valves for life-saving coronavirus treatments
39
The valve typically costs about $11,000 — the volunteers made them for about $1

By Jay Peters@jaypeters  Mar 17, 2020, 5:51pm CDT
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Image: Massimo Temporelli
A medical device manufacturer has threatened to sue a group of volunteers in Italy that 3D printed a valve used for life-saving coronavirus treatments. The valve typically costs about $11,000 from the medical device manufacturer, but the volunteers were able to print replicas for about $1 (via Techdirt).

A hospital in Italy was in need of the valves after running out while treating patients for COVID-19. The hospital’s usual supplier said they could not make the valves in time to treat the patients, according to Metro. That launched a search for a way to 3D print a replica part, and Cristian Fracassi and Alessandro Ramaioli, who work at Italian startup Isinnova, offered their company’s printer for the job, reports Business Insider.

However, when the pair asked the manufacturer of the valves for blueprints they could use to print replicas, the company declined and threatened to sue for patent infringement, according to Business Insider Italia. Fracassi and Ramaioli moved ahead anyway by measuring the valves and 3D printing three different versions of them.

 
The new coronavirus is spreading through the US, and several states have made emergency declarations. The World Health Organization has declared it a pandemic. Here are the basics:

EVERYTHING YOU NEED TO KNOW ABOUT THE CORONAVIRUS
So far, the valves they made have worked on 10 patients as of March 14th, according to Massimo Temporelli, the founder of Italian manufacturing solutions company FabLab who helped recruit Fracassi and Ramaioli to print the replica valves.

“[The patients] were people in danger of life, and we acted. Period,” said Fracassi in a Facebook post. He also said that “we have no intention of profit on this situation, we are not going to use the designs or product beyond the strict need for us forced to act, we are not going to spread the drawing.”

Here’s a good look at the valves, shared by Italy’s Minister of Technological Innovation Paola Pisano on Twitter.

 

Italy has more than 31,500 confirmed infections of COVID-19, the disease caused by the novel coronavirus, and more than 2,500 confirmed deaths. Both figures trail only China.

 

 

guess we found out where the bastid that likes to sue a family with a sick child works...

[smuggs 9353]

32 minutes ago, NoName said:

  Reveal hidden contents

Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1
March 17, 2020
DOI: 10.1056/NEJMc2004973
Metrics 

TO THE EDITOR:
A novel human coronavirus that is now named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (formerly called HCoV-19) emerged in Wuhan, China, in late 2019 and is now causing a pandemic.1 We analyzed the aerosol and surface stability of SARS-CoV-2 and compared it with SARS-CoV-1, the most closely related human coronavirus.2

We evaluated the stability of SARS-CoV-2 and SARS-CoV-1 in aerosols and on various surfaces and estimated their decay rates using a Bayesian regression model (see the Methods section in the Supplementary Appendix, available with the full text of this letter at NEJM.org). SARS-CoV-2 nCoV-WA1-2020 (MN985325.1) and SARS-CoV-1 Tor2 (AY274119.3) were the strains used. Aerosols (<5 μm) containing SARS-CoV-2 (105.25 50% tissue-culture infectious dose [TCID50] per milliliter) or SARS-CoV-1 (106.75-7.00 TCID50 per milliliter) were generated with the use of a three-jet Collison nebulizer and fed into a Goldberg drum to create an aerosolized environment. The inoculum resulted in cycle-threshold values between 20 and 22, similar to those observed in samples obtained from the upper and lower respiratory tract in humans.

Our data consisted of 10 experimental conditions involving two viruses (SARS-CoV-2 and SARS-CoV-1) in five environmental conditions (aerosols, plastic, stainless steel, copper, and cardboard). All experimental measurements are reported as means across three replicates.

Figure 1.

Viability of SARS-CoV-1 and SARS-CoV-2 in Aerosols and on Various Surfaces.
SARS-CoV-2 remained viable in aerosols throughout the duration of our experiment (3 hours), with a reduction in infectious titer from 103.5 to 102.7 TCID50 per liter of air. This reduction was similar to that observed with SARS-CoV-1, from 104.3 to 103.5 TCID50 per milliliter (Figure 1A).

SARS-CoV-2 was more stable on plastic and stainless steel than on copper and cardboard, and viable virus was detected up to 72 hours after application to these surfaces (Figure 1A), although the virus titer was greatly reduced (from 103.7 to 100.6 TCID50 per milliliter of medium after 72 hours on plastic and from 103.7 to 100.6 TCID50 per milliliter after 48 hours on stainless steel). The stability kinetics of SARS-CoV-1 were similar (from 103.4 to 100.7 TCID50 per milliliter after 72 hours on plastic and from 103.6 to 100.6 TCID50 per milliliter after 48 hours on stainless steel). On copper, no viable SARS-CoV-2 was measured after 4 hours and no viable SARS-CoV-1 was measured after 8 hours. On cardboard, no viable SARS-CoV-2 was measured after 24 hours and no viable SARS-CoV-1 was measured after 8 hours (Figure 1A).

Both viruses had an exponential decay in virus titer across all experimental conditions, as indicated by a linear decrease in the log10TCID50 per liter of air or milliliter of medium over time (Figure 1B). The half-lives of SARS-CoV-2 and SARS-CoV-1 were similar in aerosols, with median estimates of approximately 1.1 to 1.2 hours and 95% credible intervals of 0.64 to 2.64 for SARS-CoV-2 and 0.78 to 2.43 for SARS-CoV-1 (Figure 1C, and Table S1 in the Supplementary Appendix). The half-lives of the two viruses were also similar on copper. On cardboard, the half-life of SARS-CoV-2 was longer than that of SARS-CoV-1. The longest viability of both viruses was on stainless steel and plastic; the estimated median half-life of SARS-CoV-2 was approximately 5.6 hours on stainless steel and 6.8 hours on plastic (Figure 1C). Estimated differences in the half-lives of the two viruses were small except for those on cardboard (Figure 1C). Individual replicate data were noticeably “noisier” (i.e., there was more variation in the experiment, resulting in a larger standard error) for cardboard than for other surfaces (Fig. S1 through S5), so we advise caution in interpreting this result.

We found that the stability of SARS-CoV-2 was similar to that of SARS-CoV-1 under the experimental circumstances tested. This indicates that differences in the epidemiologic characteristics of these viruses probably arise from other factors, including high viral loads in the upper respiratory tract and the potential for persons infected with SARS-CoV-2 to shed and transmit the virus while asymptomatic.3,4 Our results indicate that aerosol and fomite transmission of SARS-CoV-2 is plausible, since the virus can remain viable and infectious in aerosols for hours and on surfaces up to days (depending on the inoculum shed). These findings echo those with SARS-CoV-1, in which these forms of transmission were associated with nosocomial spread and super-spreading events,5 and they provide information for pandemic mitigation efforts.

Neeltje van Doremalen, Ph.D.
Trenton Bushmaker, B.Sc.
National Institute of Allergy and Infectious Diseases, Hamilton, MT

Dylan H. Morris, M.Phil.
Princeton University, Princeton, NJ

Myndi G. Holbrook, B.Sc.
National Institute of Allergy and Infectious Diseases, Hamilton, MT

Amandine Gamble, Ph.D.
University of California, Los Angeles, Los Angeles, CA

Brandi N. Williamson, M.P.H.
National Institute of Allergy and Infectious Diseases, Hamilton, MT

Azaibi Tamin, Ph.D.
Jennifer L. Harcourt, Ph.D.
Natalie J. Thornburg, Ph.D.
Susan I. Gerber, M.D.
Centers for Disease Control and Prevention, Atlanta, GA

James O. Lloyd-Smith, Ph.D.
University of California, Los Angeles, Los Angeles, CA, Bethesda, MD

Emmie de Wit, Ph.D.
Vincent J. Munster, Ph.D.
National Institute of Allergy and Infectious Diseases, Hamilton, MT 
vincent.munster@nih.gov

Supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health, and by contracts from the Defense Advanced Research Projects Agency (DARPA PREEMPT No. D18AC00031, to Drs. Lloyd-Smith and Gamble), from the National Science Foundation (DEB-1557022, to Dr. Lloyd-Smith), and from the Strategic Environmental Research and Development Program of the Department of Defense (SERDP, RC-2635, to Dr. Lloyd-Smith).

Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.

The findings and conclusions in this letter are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention (CDC). Names of specific vendors, manufacturers, or products are included for public health and informational purposes; inclusion does not imply endorsement of the vendors, manufacturers, or products by the CDC or the Department of Health and Human Services.

This letter was published on March 17, 2020, at NEJM.org.

Dr. van Doremalen, Mr. Bushmaker, and Mr. Morris contributed equally to this letter.

 

 

 

plastic and steel: viable virus after 72 hours

copper: no viable virus 8 hours 

cardboard: no viable virus after 24 hours

 

6 minutes ago, Chewy's Hairy Horn said:

...and how about granite or stone?

 

Any info on leather or silicone?

[Loco 3752]

[Js1 85311]

1 minute ago, smuggs said:

 

 

Any info on leather or silicone?

I think your dildo will be okay 

[utee94 15811]

3 minutes ago, smuggs said:

 

 

Any info on leather or silicone?

Or PVC...?

[mchookem 16327]

thanks to the responses to my mini meltdown last night. i realize our situation is just one of billions at this point, and it could be so much worse...we have used the grill, and we are 'camping' on our patio w/ the fridge and microwave...just the thought of being shut in/shut off for months without having a fully functioning house got to me a bit yesterday. 

[Loco 3752]

16 minutes ago, Captainant said:

For profit healthcare institution (the IP holder) putting their profits above the health outcomes of their patients?? I don't believe it!

For profit medicine has been a thing for a long time.   Just think of prescription medicine... same fucking thing, just a lot less attention paid to it.

[Newdoc 3439]

17 minutes ago, Chewy's Hairy Horn said:

...and how about granite or stone?

Surly Covid humblebrag?

[XYZ 2154]

We gonna have to gamble and release a coronavirus vaccine much earlier than the 18 months that is the protocol.

[Skipper 6133]

8 hours ago, C-Man said:

 

Talked to my doctor's PA yesterday and they weren't concerned at all. I think I'm actually taking an ARB as opposed to ACE inhibitor but maybe those are one and the same.

You are probably going to be able to better stay on top of state of evidence via independent research.  Just FYI, MD Peter Attia (via his instagram) had a 6 or 7 minute clip posted Tues night regarding their current  thinking.  Seems it is very patient specific but to the extent you are able to able to regulate BP at an equal level via an alternative mechanism it might be worth trying in the interim but still not enough data for anyone to know if really beneficial.

[jeevsie 3733]

29 minutes ago, NoName said:

talk about out of touch...

The Verge: Medical company threatens to sue volunteers that 3D-printed valves for life-saving coronavirus treatments

Full Text:

  Reveal hidden contents

 

Medical company threatens to sue volunteers that 3D-printed valves for life-saving coronavirus treatments
39
The valve typically costs about $11,000 — the volunteers made them for about $1

By Jay Peters@jaypeters  Mar 17, 2020, 5:51pm CDT
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Image: Massimo Temporelli
A medical device manufacturer has threatened to sue a group of volunteers in Italy that 3D printed a valve used for life-saving coronavirus treatments. The valve typically costs about $11,000 from the medical device manufacturer, but the volunteers were able to print replicas for about $1 (via Techdirt).

A hospital in Italy was in need of the valves after running out while treating patients for COVID-19. The hospital’s usual supplier said they could not make the valves in time to treat the patients, according to Metro. That launched a search for a way to 3D print a replica part, and Cristian Fracassi and Alessandro Ramaioli, who work at Italian startup Isinnova, offered their company’s printer for the job, reports Business Insider.

However, when the pair asked the manufacturer of the valves for blueprints they could use to print replicas, the company declined and threatened to sue for patent infringement, according to Business Insider Italia. Fracassi and Ramaioli moved ahead anyway by measuring the valves and 3D printing three different versions of them.

 
The new coronavirus is spreading through the US, and several states have made emergency declarations. The World Health Organization has declared it a pandemic. Here are the basics:

EVERYTHING YOU NEED TO KNOW ABOUT THE CORONAVIRUS
So far, the valves they made have worked on 10 patients as of March 14th, according to Massimo Temporelli, the founder of Italian manufacturing solutions company FabLab who helped recruit Fracassi and Ramaioli to print the replica valves.

“[The patients] were people in danger of life, and we acted. Period,” said Fracassi in a Facebook post. He also said that “we have no intention of profit on this situation, we are not going to use the designs or product beyond the strict need for us forced to act, we are not going to spread the drawing.”

Here’s a good look at the valves, shared by Italy’s Minister of Technological Innovation Paola Pisano on Twitter.

 

Italy has more than 31,500 confirmed infections of COVID-19, the disease caused by the novel coronavirus, and more than 2,500 confirmed deaths. Both figures trail only China.

 

 

The dudes who made these knock offs are bad asses.

[Newdoc 3439]

8 hours ago, Anastasis said:

ACEI and ARBs have similar effects in terms of ACE2 upregulation. They work mechanistically differently, but in this specific regard they have the same relevant effect wrt ACE 2. 

My change of thinking is based on re-evaluation of the time frames that we are looking at. My earlier assessment was based on a 7-10 day exposure time frame.  We have (hopefully) flattened that, which means the exposure window is significantly increased. I think that we are socially isolated for many weeks at this point, and exposures could occur downstream.  Might make a difference.  Makes sense by my reasoning to consider tapering off the ACEI or ARBs and monitor BP levels.  If you are diabetic, or have kidney disease, or have other complicating factors the risk dynamic is different.  But for myself, I just have essential hypertension and some mildly elevated LFTs. Over the next couple of weeks, I am not particularly worried about either. 

This appears to be a reasonable assessment. The short term variation in blood pressure from switching agents may have short term benefits that outweigh long term risks. I wonder how long it would take the body to down regulate ACE 2 receptors however?  This can probably be done over the phone or with a virtual visit with your doctor.  Looks like many people are going with amlodipine instead of their ACE or ARB which aside from some ankle edema, appears to be a cheap and effective alternative.

[utee94 15811]

6 minutes ago, mchookem said:

thanks to the responses to my mini meltdown last night. i realize our situation is just one of billions at this point, and it could be so much worse...we have used the grill, and we are 'camping' on our patio w/ the fridge and microwave...just the thought of being shut in/shut off for months without having a fully functioning house got to me a bit yesterday. 

I feel for you.  Your situation, and those with kids that are currently stuck in other countries, or folks with kids that are seniors that are looking at missing out on prom/graduation/sports-- those are all tough situations.  They're not life of death but they're human stories and they're meaningful stories.

It's going to take ALL of us, knowing we're in it together, to get through it okay.  And the scars aren't only going to be physical.

But you're going to manage.  It might even be fun to pretend you're homeless or something, challenge yourself to get by with as few comforts as possible.

 

[Wally Pryor 5261]

More uplifting news / projections:

https://www.businessinsider.com/us-coronavirus-warning-pandemic-will-last-18-months-multiple-waves-2020-3

 

 

[Pancho 44757]

3 minutes ago, XYZ said:

We gonna have to gamble and release a coronavirus vaccine much earlier than the 18 months that is the protocol.

Is 18 months a protocol or just the time frame to see whether or not a vaccine actually works combined with producing enough for worldwide use?

They’ve already skipped protocol by injecting a prototype vaccine directly into humans without doing a trial on mice.  I thought 18 months was just the time frame to produce, see if it works, then it if works, send it out worldwide,

[Onboard 2.0 9083]

1 hour ago, TXSG8R said:

Not taking a shot at you, but why do you think it was such a simple, voluntary decision to move manufacturing there?  Americans don’t want to pay for goods with American labor tacked onto them. It would be great if this caused a great awakening, but it’s more likely that a handful of companies shift things to a different country (Mexico, Taiwan, etc) to diversify.  Ultimately China undercuts everyone on labor again and companies line back up to get shit made there.  That place has been an IP chop shop for a while now and companies still roll their shit in there. 

Yep, I know it wasn't that simple. It's been a move occurring over the years to lots of offshore locations. Free enterprise, cheaper costs are the driver. The BLATANT  intellectual theft is the thing that really pisses me off.

[XYZ 2154]

Can somebody explain how a virus infection works generally? Like, let’s say that somebody how is contagious coughs on you and passes the virus to you. That’s day zero. Then what, the virus starts multiplying inside of you? How many days until you become contagious yourself? Does becoming contagious coincide with feeling symptoms, or are those two separate things? What happens when you recover? Is your body killing the virus? Do you have no virus left alive in your body after you recovered, or you still have it but are immune to it?

[Pancho 44757]

 

[NoName 16351]

 

full size:

Spoiler

 

 

 

[Onboard 2.0 9083]

1 minute ago, XYZ said:

Can somebody explain how a virus infection works generally? Like, let’s say that somebody how is contagious coughs on you and passes the virus to you. That’s day zero. Then what, the virus starts multiplying inside of you? How many days until you become contagious yourself? Does becoming contagious coincide with feeling symptoms, or are those two separate things? What happens when you recover? Is your body killing the virus? Do you have no virus left alive in your body after you recovered, or you still have it but are immune to it?

With this virus you can be contagious before showing symptoms of the illness from the reading I've done, and comments seen posted here.

[utee94 15811]

Just now, Onboard 2.0 said:

Yep, I know it wasn't that simple. It's been a move occurring over the years to lots of offshore locations. Free enterprise, cheaper costs are the driver. The BLATANT  intellectual theft is the thing that really pisses me off.

I've visited our ODM's factories.  Massive assembly lines side-by-side, where they produce Lenovo, HP, Dell, Apple, and their own-branded products.  IP wanders across those lines on a daily basis, and they DGAF.  

But, Americans like our $200 laptops and bigscreen TVs, so it will continue.

[Loco 3752]

5 minutes ago, Pancho said:

Is 18 months a protocol or just the time frame to see whether or not a vaccine actually works combined with producing enough for worldwide use?

They’ve already skipped protocol by injecting a prototype vaccine directly into humans without doing a trial on mice.  I thought 18 months was just the time frame to produce, see if it works, then it if works, send it out worldwide,

Narrator:  That was because mice aren't susceptible to the C-19 virus

[Sandman 3403]

26 minutes ago, MissingInAction said:

Do you work for the public sector? Because that describes exactly what is happening in my environment now. I am a senior IT support employee and I JUST got a laptop so I can help people from home. 

Yes, I work for a state agency (not texas). We're so far behind, tech-wise, that it's embarrassing. I have to use Lotus notes for one of my jobs. We just got rid of a DOS option for another. There's a terminal in here that's running Windows 3.1 because the program won't work on newer versions.

[XYZ 2154]

3 minutes ago, Pancho said:

Is 18 months a protocol or just the time frame to see whether or not a vaccine actually works combined with producing enough for worldwide use?

They’ve already skipped protocol by injecting a prototype vaccine directly into humans without doing a trial on mice.  I thought 18 months was just the time frame to produce, see if it works, then it if works, send it out worldwide,

What I understood from reading above on this same page is that when they do trials of a new vaccine on humans, they want to monitor them for 14 months to make sure the vaccine doesn’t give them the disease. So between that and actually ramping up production to inoculate the whole world, at least 18 months. My guess is that they’re gonna have to cut down the 14-month observation period.

[Onboard 2.0 9083]

1 minute ago, Loco said:

Narrator:  That was because mice aren't susceptible to the C-19 virus

So we should just eat more cheese ?

[Incredulity 11665]

45 minutes ago, Sandman said:

About 5 years or so ago, I tried to get my office to move into the 21st century and move most of our processes online. Yeah, my main goal was to try to work from home but my point was valid, our shit is incredibly outdated. Nobody wanted to hear it, everything was fine, it would be a disaster to change anything. Now they're scrambling to figure out how to get shit done remotely. We had the $$$ to implement this plan and nobody could be bothered to do anything. They always seem to figure this shit out after it's too late. 

that's the essence of humanity

[Loco 3752]

 

[NoName 16351]

41 minutes ago, NoName said:

talk about out of touch...

The Verge: Medical company threatens to sue volunteers that 3D-printed valves for life-saving coronavirus treatments

Full Text:

  Reveal hidden contents

 

Medical company threatens to sue volunteers that 3D-printed valves for life-saving coronavirus treatments
39
The valve typically costs about $11,000 — the volunteers made them for about $1

By Jay Peters@jaypeters  Mar 17, 2020, 5:51pm CDT
Share this story
Share this on Facebook
Share this on Twitter
SHARE
All sharing options
 
Image: Massimo Temporelli
A medical device manufacturer has threatened to sue a group of volunteers in Italy that 3D printed a valve used for life-saving coronavirus treatments. The valve typically costs about $11,000 from the medical device manufacturer, but the volunteers were able to print replicas for about $1 (via Techdirt).

A hospital in Italy was in need of the valves after running out while treating patients for COVID-19. The hospital’s usual supplier said they could not make the valves in time to treat the patients, according to Metro. That launched a search for a way to 3D print a replica part, and Cristian Fracassi and Alessandro Ramaioli, who work at Italian startup Isinnova, offered their company’s printer for the job, reports Business Insider.

However, when the pair asked the manufacturer of the valves for blueprints they could use to print replicas, the company declined and threatened to sue for patent infringement, according to Business Insider Italia. Fracassi and Ramaioli moved ahead anyway by measuring the valves and 3D printing three different versions of them.

 
The new coronavirus is spreading through the US, and several states have made emergency declarations. The World Health Organization has declared it a pandemic. Here are the basics:

EVERYTHING YOU NEED TO KNOW ABOUT THE CORONAVIRUS
So far, the valves they made have worked on 10 patients as of March 14th, according to Massimo Temporelli, the founder of Italian manufacturing solutions company FabLab who helped recruit Fracassi and Ramaioli to print the replica valves.

“[The patients] were people in danger of life, and we acted. Period,” said Fracassi in a Facebook post. He also said that “we have no intention of profit on this situation, we are not going to use the designs or product beyond the strict need for us forced to act, we are not going to spread the drawing.”

Here’s a good look at the valves, shared by Italy’s Minister of Technological Innovation Paola Pisano on Twitter.

 

Italy has more than 31,500 confirmed infections of COVID-19, the disease caused by the novel coronavirus, and more than 2,500 confirmed deaths. Both figures trail only China.

 

 

[XYZ 2154]

2 minutes ago, Incredulity said:

that's the essence of humanity

That’s exactly what I was gonna say. Sandman basically described humans in action.

[Pancho 44757]

6 minutes ago, Loco said:

Narrator:  That was because mice aren't susceptible to the C-19 virus

That’s not what I got from reading one of the articles posted here.  I knew about the dogs not getting it thing.  Regardless....

[MissingInAction 25037]

5 minutes ago, Sandman said:

Yes, I work for a state agency (not texas). We're so far behind, tech-wise, that it's embarrassing. I have to use Lotus notes for one of my jobs. We just got rid of a DOS option for another. There's a terminal in here that's running Windows 3.1 because the program won't work on newer versions.

Wow! And I thought I had it rough supporting Foxpro on a win95 machine. Our customer facing tech is the latest available, but everything the Luddite execs can't see or understand is easily 20 years out of date. 

[Fudge Nuggets 19190]

I wonder how much they had to pay thr fucker that got the first injection with no prior animal testing?

[Coelenterate Fuccboi 13091]

32 minutes ago, Loco said:

Maybe some us have been dressing like this all along.

[Loco 3752]

1 minute ago, Pancho said:

That’s not what I got from reading one of the articles posted here.  I knew about the dogs not getting it thing.  Regardless....

Another reason it shouldn't be rushed is the results of '76 Swine Flu vaccine that was rushed into production...  Guillian-Barre

https://www.smithsonianmag.com/smart-news/long-shadow-1976-swine-flu-vaccine-fiasco-180961994/

[Constant 6731]

2 minutes ago, Fudge Nuggets said:

I wonder how much they had to pay thr fucker that got the first injection with no prior animal testing?

A year supply of Ramen.