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Formerly DT: COVID-19 - Featuring Lots of Politics, now CR because political talk not going away

InkaUtexas

By InkaUtexas
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Uncle Boobs
Uncle Boobs

Against my better judgment and several beers deep, I have taken you up on this, potentially ending my streak of totally worthless posts. I have done 3 and 7 day averages only on the Worldometer data. 

Brisketexan
Brisketexan

Daughter’s home. A little PTSD, we’re picking up Whataburger to help.

Coelenterate Fuccboi
Coelenterate Fuccboi

Just try and imagine GreenspointTexas being the person to intubate you as you fight for your life against COVID-19. You’re laying there gasping for air while he chastises you for all the things you li

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conVINCEd

conVINCEd 21469

Posted
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4 minutes ago, NateHitch said:


 

 


Circling back to this one, turns out this guy might not be a loon. The chloroquine treatment is gaining some traction, something to keep an eye on

 

When I read that there was a shortage because docs were prescribing it to each other it piqued my interest.

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Hagbard Celine

Hagbard Celine 10858

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Treatment: Chloroquine phosphate (marketed by Bayer as Resochin®)

Type: Phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Resochin was discovered by Bayer and introduced into clinical practice in 1947 to treat malaria.

Status: Chloroquine has “shown fairly good efficacy” according to Sun Yanrong, deputy head of the China National Center for Biotechnology Development under the Ministry of Science and Technology (MOST), the state-owned Xinhua news agency reported on February 17, following clinical trials in over 10 hospitals in Beijing, as well as in south China’s Guangdong Province and central China’s Hunan Province.

On March 16, researchers at the University of Queensland in Australia said they hoped to launch large-scale trials of chloroquine, as well as AbbVie’s Kaletra®(See above), after both drugs successfully treated patients with COVID-19.

Chinese news outlet Shine reported March 10 that Bayer had donated about €1.5 million (about $1.7 million) in medicines and additional financial aid to the Chinese Red Cross to support prevention, diagnosis, treatment, and containment of COVID-19 in China. Bayer’s Kunming, China factory mobilized 50,000 disposable surgical masks and 10,000 R95 medical masks to donate to the Kunming Red Cross Society, in response to a call from the Yunnan Provincial Department of Commerce.

Chloroquine and remdesivir were “highly effective in the control of 2019-nCoV infection in vitro,” a team of Chinese researchers reported in a study published February 4 in Cell Research. After China’s National Health Commission included chloroquine phosphate in its latest treatment guidelines for COVID-19 pneumonia, eight Chinese companies sped up manufacturing and supply of the drug, Shanghai Daily reported February 20.

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Hagbard Celine

Hagbard Celine 10858

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Treatment: Favipiravir (marketed by Fujifilm as Avigan and by Hisun in China as Favilavir)

Type: Broad spectrum anti-viral agent that is designed to selectively and potently inhibit the RNA-dependent RNA polymerase (RdRp) of RNA viruses. Japan has approved Avigan for novel or re-emergent influenza and was previously used to treat Ebola patients in Guinea.

Status: Zhang Xinmin, an official at China’s Science and Technology Ministry, told reporters March 17 that favipiravir produced positive results in clinical trials in Wuhan and Shenzhen involving 340 patients—including a shortening of the time after treatment that patients tested negative for COVID-19 from 11 days to four, and improved lung conditions in 91% of treated patients vs. 62% of untreated patients, as measured via x-rays.

Japan’s Health Minister Katsunobu Kato said February 22 that his ministry would recommend Avigan, developed by Fujifilm-owned Toyama Chemical, for use as a coronavirus treatment after test dosages appeared effective in mild and asymptomatic cases at least two medical institutions. In China, the National Health Commission on February 17 approved Hisun’s version of the drug as an investigational treatment for SARS-CoV-2 in an upcoming clinical trial being conducted in Shenzhen.

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Incredulity

Incredulity 11669

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Japan’s Health Minister Katsunobu Kato said February 22 that his ministry would recommend Avigan, developed by Fujifilm-owned Toyama Chemical, for use as a coronavirus treatment after test dosages appeared effective in mild and asymptomatic cases at least two medical institutions.

 

it’s a miracle.

also effective in asymptotic cases... everything.

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Neonmoon

Neonmoon 38129

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I watched some doctor on CNN say Chloroquine has not been trialed to treat Covid and people need to be patient. Yes it’s a FDA approved medicine for malaria but not for Covid. Ummm who gives a fuck. I understand there could be unforeseen consequences but if someone is between living or dying, I doubt the patient gives a fuck that Chloloquine hasn’t been approved to treat Covid 

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conVINCEd

conVINCEd 21469

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10 minutes ago, Pato del Muerto said:

I know someone who takes it for RA and she is a little concerned about being able to refill her prescription. 

What’s RA?  It’s a malaria medication, correct?  I briefly looked into all of the malaria shit before I went to Africa a few years ago.  I made the determination that I was better getting treated if I got it, rather than taking the preventatives because I was going to a somewhat lower risk area.  It also piqued my interest when one of the surl did a deep dive into this shit and determined that he needed to get a scrip for it by any means necessary, took it, and started feeling better.

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DalTxHornFan

DalTxHornFan 3101

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Posted (edited)
2 minutes ago, Neonmoon said:

I watched some doctor on CNN say Chloroquine has not been trialed to treat Covid and people need to be patient. Yes it’s a FDA approved medicine for malaria but not for Covid. Ummm who gives a fuck. I understand there could be unforeseen consequences but if someone is between living or dying, I doubt the patient gives a fuck that Chloloquine hasn’t been approved to treat Covid 

I'm not a physician, but it is my understanding that there is no requirement for additional FDA testing of "off label" uses of an otherwise FDA approved script.  Docs chime in.

Edited by DalTxHornFan
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dcar00

dcar00 14181

Posted
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2 minutes ago, Brisketexan said:


And be wondered about CPAP machines - can those be adapted?

I saw something about that but those just really keep your airway open they don't really breathe for you.  worth a shot I suppose.  nothing should be off the table.

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dcar00

dcar00 14181

Posted
Posted
Just now, tjhooker said:

Yes, off label you don't have to test but often times won't be covered by insurance and opens docs up to liability. 

"I think I've got malaria doc, cough, cough"

"yes I do believe you might have malaria good sir, here take this drug that we know doesn't kill anyone"

seriously though, the only thing I can think of is using in it combination with some other drug could be a potential issue.

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Hmmm

Hmmm 155

Posted
Posted
13 minutes ago, Modessit said:

I wonder if some enterprising folks could figure out how to make portable or temporary ventilators from aquarium aerators?

i've heard of this device that filters smoke through h2o.  could be bong.

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Newdoc

Newdoc 3439

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17 minutes ago, DalTxHornFan said:

I'm not a physician, but it is my understanding that there is no requirement for additional FDA testing of "off label" uses of an otherwise FDA approved script.  Docs chime in.

This is correct and there really isn’t an increased liability if we are using a drug off label with good standard of care and informed patient consent.  The insurance company doesn’t care either unless it’s an expensive branded drug which the chloroquines are not. At least not now, and if you can get it.

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RockyMountainHighHorn

RockyMountainHighHorn 890

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As a temporary “Californian” this is absolutely mind blowing. Saw some madness this week but nothing like the past 2 hours since the news. A few notes-on the scrolling bar of the news it said “local health officials predict that 56% of all of California residents will eventually get the virus”. Yeah that was cool to read. Second, during the online summit I posted about yesterday, a specialist said that they have found that copper does kill the virus. Thought that was interesting there wasn’t more media on that. A roll of copper tape online is actually pretty cheap. He urged buildings to cover buttons and handles with copper tape to stop the spread. Do with that info as you will. Thirdly, with people being “safe at home” for a month now, any divorce lawyer sure is going to make some bank here soon...sadly. And lastly, be safe and good luck. No, no, lastly, Hook em.

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gmr548

gmr548 16576

Posted
Posted
This is where federal gov't needs to come in and shut it down. Letting the states piece meal this while still allowing  air travel is not going to work.
Shut down all the airports, close all non-essential businesses, etc etc
Too many dipshits out there.

Seriously. You can't have states and localities on different pages AND have air travel. That's stupid. Cat's out of the bag it seems though.
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bernorange

bernorange 8361

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Quote

Argentina imposed a nationwide lockdown to stem the coronavirus pandemic, marking one of the strictest measures taken by any Latin American nation.

Starting Friday, citizens are only permitted to leave their homes for essential services such as supermarkets and pharmacies, President Alberto Fernandez said. The lockdown, which will be enforced by security forces, lasts until March 31.

“We’ll be absolutely inflexible in the enforcement,” Fernandez said. “This is an exceptional measure in an exceptional time -- and yet still under the framework of democracy.”
...

https://www.bloomberg.com/news/articles/2020-03-20/argentina-orders-exceptional-lockdown-in-bid-to-contain-virus

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Shaggybevo

Shaggybevo 353

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Teva to Donate Potential COVID-19 Treatment, Hydroxychloroquine Sulfate Tablets to Hospitals Nationwide

Teva will donate 6 Million tablets through wholesalers to hospitals by March 31, and more than 10 Million within a month

TEL AVIV, Israel & PARSIPPANY, N.J.--(BUSINESS WIRE)-- Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) announced today the immediate donation of more than 6 million doses of hydroxychloroquine sulfate tablets through wholesalers to hospitals across the U.S. to meet the urgent demand for the medicine as an investigational target to treat COVID-19. The company is also looking at additional ways to address the global need.

https://www.tevausa.com/news-and-media/press-releases/teva-to-donate-potential-covid-19-treatment-hydroxychloroquine-sulfate-tablets-to-hospitals-nationwide-/

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dcbc

dcbc 14478

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34 minutes ago, Hmmm said:

i've heard of this device that filters smoke through h2o.  could be bong.

If the pot heads save us all in reverse by making a ventilator out of a bong, I'll be like, oh, wow!

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Texas Jeff

Texas Jeff 1945

Posted
Posted (edited)

Some good news, Italy's new case rate is bending down a bit if you look at the log scale.  It's still exponential but the rate of growth is slowing.  It took them 6 days to go from 100 to 1K, 10 days to go from 1K to 10K, and they are now right at 10 days without hitting 100k.  Of course, it's possible they have reached the limit of their ability to test per day.  But still it appears to be slowing but still exponential.

Meanwhile in the US, we are right on a log-linear track.  Eight days to go from 100 to 1K, eight days to go from 1K to 10K, and we are now seven days away from 100K.  I think we will see a knee in the log-linear curve sometime in the next week as the effects of self-isolation start to show.  Hopefully we don't hit 100K cases by next Thursday.  If we keep it under 100K through the end of the month, that is real progress and a sign that all of the stay at home efforts are paying off.

If we hit 100K prior to next Thursday, well then you can say that maybe testing is ramping up and catching more cases but our growth rate is still exponential and speeding up.  Not great, Bob...

Edited by Texas Jeff
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Anastasis

Anastasis 23469

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17 minutes ago, Shaggybevo said:

Teva to Donate Potential COVID-19 Treatment, Hydroxychloroquine Sulfate Tablets to Hospitals Nationwide

Teva will donate 6 Million tablets through wholesalers to hospitals by March 31, and more than 10 Million within a month

TEL AVIV, Israel & PARSIPPANY, N.J.--(BUSINESS WIRE)-- Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) announced today the immediate donation of more than 6 million doses of hydroxychloroquine sulfate tablets through wholesalers to hospitals across the U.S. to meet the urgent demand for the medicine as an investigational target to treat COVID-19. The company is also looking at additional ways to address the global need.

https://www.tevausa.com/news-and-media/press-releases/teva-to-donate-potential-covid-19-treatment-hydroxychloroquine-sulfate-tablets-to-hospitals-nationwide-/

This is good shit. More of it from Pharma please. 

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tx 3 putt

tx 3 putt 76928

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Posted
18 minutes ago, Shaggybevo said:

Teva to Donate Potential COVID-19 Treatment, Hydroxychloroquine Sulfate Tablets to Hospitals Nationwide

Teva will donate 6 Million tablets through wholesalers to hospitals by March 31, and more than 10 Million within a month

TEL AVIV, Israel & PARSIPPANY, N.J.--(BUSINESS WIRE)-- Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) announced today the immediate donation of more than 6 million doses of hydroxychloroquine sulfate tablets through wholesalers to hospitals across the U.S. to meet the urgent demand for the medicine as an investigational target to treat COVID-19. The company is also looking at additional ways to address the global need.

https://www.tevausa.com/news-and-media/press-releases/teva-to-donate-potential-covid-19-treatment-hydroxychloroquine-sulfate-tablets-to-hospitals-nationwide-/

 

jam up of them 

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Hate

Hate 20108

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Anyone else think (without clicking the link) why on Earth does a sandal company have that many malaria tablets??  It may also be because I'm nearing drunk, but still.

Edited by Hate
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triplehorn

triplehorn 2664

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37 minutes ago, Newdoc said:

This is correct and there really isn’t an increased liability if we are using a drug off label with good standard of care and informed patient consent.  The insurance company doesn’t care either unless it’s an expensive branded drug which the chloroquines are not. At least not now, and if you can get it.

Correct.  As you are likely aware, there are many examples of medications that are commonly prescribed for off-label purposes, several of which do have legitimate potential side effects down the line but are used for things like insomnia or anxiety - second generation antipsychotics in particular.  Documenting informed consent involving risks and benefits while not going Daktari on your patient is sufficient.

The chloroquines are appropriate for off-label use because they are well established with a long track record.  The theoretical mechanism has been demonstrated in vitro and there are early emerging accounts out of China, SoKo, and France with basic protocols that appear to offer benefit, if not dramatic benefit.  That said, I'd pull stock and funnel it immediately to health care providers in the high exposure acute care settings to have if desired.  The potential prophylactic benefits of chloroquine for exposed contacts needs to be considered.

edit: holy crap just saw the Teva news.  could be a real game changer.  couldn't be more timely 

Edited by triplehorn
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Not a cat

Not a cat 5655

Posted
Posted
29 minutes ago, Shaggybevo said:

Teva to Donate Potential COVID-19 Treatment, Hydroxychloroquine Sulfate Tablets to Hospitals Nationwide

Teva will donate 6 Million tablets through wholesalers to hospitals by March 31, and more than 10 Million within a month

TEL AVIV, Israel & PARSIPPANY, N.J.--(BUSINESS WIRE)-- Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) announced today the immediate donation of more than 6 million doses of hydroxychloroquine sulfate tablets through wholesalers to hospitals across the U.S. to meet the urgent demand for the medicine as an investigational target to treat COVID-19. The company is also looking at additional ways to address the global need.

https://www.tevausa.com/news-and-media/press-releases/teva-to-donate-potential-covid-19-treatment-hydroxychloroquine-sulfate-tablets-to-hospitals-nationwide-/

Insert the Jews did this gif.

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Texas Jeff

Texas Jeff 1945

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Looking at the data some more, we are now at the point where China was on Feb 1st.  China got to zero new cases yesterday, about 46 days later, with a massive lockdown.  For the US, 46 days from today is May 4th.  We could get this under control and be at the same spot sometime in May, but April is going to suck.

 

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Pasken

Pasken 1309

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Posted
11 minutes ago, Texas Jeff said:

Looking at the data some more, we are now at the point where China was on Feb 1st.  China got to zero new cases yesterday, about 46 days later, with a massive lockdown.  For the US, 46 days from today is May 4th.  We could get this under control and be at the same spot sometime in May, but April is going to suck.

 

Did you not see the massive crowds in Florida???

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ChiTownDoc

ChiTownDoc 21152

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Posted
1 hour ago, Hagbard Celine said:

@ChiTownDoc

Others did a good job.  I'm not an ID doc and getting down to cell bio is not my thing but I'll give it a stab in layman's terms.  Chloroquine is old as dirt and cheap.  Should definitely ramp up production as it has some use, likely more in early treatment and maybe protection.  Think more like tamiflu in that it won't necessarily treat the flu but getting it on board early or prophylactically helps. 

Favipiravir is a newer 'more exotic' anti-viral that is showing a lot of promise...along with a few others.  It's difficult to tell where we are with all these as very few good studies exist but many studies that will eventually be good are underway...not enough time yet to validate results, get appropriate numbers for statistical significance etc.  

The problem is SO MANY fucking people are going to get this that even if those drugs show promise, just 3% of people not responding to these drugs and eventually progressing to respiratory failure is a complete disaster for our country/healthcare system.  So 97% efficacy for a drug actually will not bail us out...it will definitely help a lot but this is how far behind the 8ball we are. 

 

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atomheartbevo

atomheartbevo 89656

Posted
Posted (edited)
12 minutes ago, RockyMountainHighHorn said:

Very interesting that now a few of my military friends tonight were just made active. Hearing my fiancé theorize why that happened was also gold. Something something Marshall law something war on the streets something something it’s like one of those purge movies on purge night. 

We don’t have a large enough military, even with NG, in this country for this stuff.   Like I and others said, we really couldn’t even isolate a city the physical size of Houston.  

I do expect the military’s mobile hospitals to be pulled out and setup.  

Edited by atomheartbevo
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SA-KC_Horn

SA-KC_Horn 1295

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Posted (edited)

Was at SPECs and this old fuck decided to all of a sudden start whistling right in front of me as he walked right past me in the middle of the bourbon aisle, held my breath in when I saw him walking my direction, then walked away from the section.

Fuck that dude, trying slobber all over the damn place.  

Edited by SA-KC_Horn
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clapclapclap

clapclapclap 9000

Posted
Posted (edited)
1 hour ago, Modessit said:

I wonder if some enterprising folks could figure out how to make portable or temporary ventilators from aquarium aerators?

Or maybe a manual option:

3a89444f985901c2e96113cc0e6e4710.jpg

*Manuel

Edited by clapclapclap
Mama's got a squeeze box, daddy never sleeps at night
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