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CR: COVID-19 --Political Talk


Mrs Whiggins

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2 hours ago, Brisketexan said:


The second-worst one.

The worst one is the one where we end up in a nuclear conflict, too.

And actually, I’m not sure which one this is yet. There’s still time for it to get WAY worse. And if there’s one rule that this admin has NEVER broken, it’s the rule of “it can and will get worse.”

OG Ledger checking in. Its looking nuke free for you friends as you close out your Tuesday. Happy to see it. Hang in there. 

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4 hours ago, Anastasis said:

Yeah, this line of argument wrt a Sanofi grift specifically doesn't make much sense.  Read the article that Twice posted on the last page or the one I posted earlier today.  The federal government is buying this stuff it appears from regional generic drug manufacturers. It's a non-exclusive off patent drug and everybody with the capability is ramping it up on the faintest of hopes. The ability to actually move the market for Sanofi or Bayer or Teva and all the other much smaller companies is extremely limited.  If this is a grift play, it is one of the dumber ones ever.  Which maybe means it's on brand. The much smarter grift play imo woudl be an antibody diagnostic.  Once one of those are out there is a market of about 300MM americans who will be lining up for one.  

Much more likely in my opinion is that Trump has simply committed to the notion of a deus ex machina in a pill bottle, based on Rudy G, a few quacks, and some very weak french clinical data. 

The dumbfuck just has a habit of speaking where he treats things he wants to be true as though they were facts. He gives less of a shit about even appearing credible or trustworthy than anyone I've ever seen. 

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Thanks Bama Chic - 

Mayo has provided physician guidance on sudden cardiac death with the med: 

Guidance on patients at risk of drug-induced sudden cardiac death from off-label COVID-19 treatments - https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-provides-urgent-guidance-approach-to-identify-patients-at-risk-of-drug-induced-sudden-cardiac-death-from-use-of-off-label-covid-19-treatments/

Spoiler

 

ROCHESTER, Minn. ― SARS-CoV-2, the virus that causes COVID-19, continues to spread, leading to more than 20,000 deaths worldwide in less than four months. Efforts are progressing to develop a COVID-19 vaccine, but it's still likely 12 to 18 months away. 

In the meantime, the pandemic, with over 400,000 confirmed cases worldwide already, is driving researchers to find safe and effective therapies for patients with COVID-19, and an antimalarial drug is potentially on the front lines of that effort. While new and repurposed drugs are being tested in clinical trials, some of these promising drugs are simultaneously being used off-label for compassionate use to treat patients. 

Some of the medications being used to treat COVID-19 are known to cause drug-induced prolongation of the QTc of some people. The QTc is an indicator of the health of the heart's electrical recharging system. Patients with a dangerously prolonged QTc are at increased risk for potentially life-threatening ventricular rhythm abnormalities that can culminate in sudden cardiac death. 

"Correctly identifying which patients are most susceptible to this unwanted, tragic side effect and knowing how to safely use these medications is important in neutralizing this threat," says Michael J. Ackerman, M.D., Ph.D., a Mayo Clinic genetic cardiologist. Dr. Ackerman is director of the  Windland Smith Rice Sudden Death Genomics Laboratory at Mayo Clinic. 

A study published in Mayo Clinic Proceedings details more information about potential dangers and the application of QTc monitoring to guide treatment when using drugs that can cause heart rhythm changes. Dr. Ackerman is the senior author of the study.

Hydroxychloroquine is a long-standing preventive and treatment drug for malaria. It also is used to manage and minimize symptoms of inflammatory immune diseases, such as lupus and rheumatoid arthritis. In laboratory tests, hydroxychloroquine can prevent the SARS-CoV and SARS-CoV-2 viruses from attaching to and entering cells. If these antiviral abilities work the same way in animals and humans, the drug could be used to treat patients and limit the number of COVID-19 deaths.

On a cellular level, potential QT-prolonging medications, like hydroxychloroquine, block one of the critical potassium channels that control the heart's electrical recharging system. This interference increases the possibility that the heart's rhythm could degenerate into dangerous erratic heart beats, resulting ultimately in sudden cardiac death. 

Accordingly, Mayo Clinic cardiologists and physician-scientists have provided urgent guidance on how to use a 12-lead ECG, telemetry or smartphone-enabled mobile ECG to determine the patient's QTc as a vital sign to identify those patients at increased risk and how to ultimately minimize the chance of drug-induced sudden cardiac death. 

"Right now, it is the Wild West out there, ranging from doing no QTc surveillance whatsoever and just accepting this potential tragic side effect as part of 'friendly fire,' to having ECG technicians going into the room of a patient with COVID-19 daily, exposing them to coronavirus and consuming personal protective equipment," says Dr. Ackerman. "Here Mayo Clinic has stepped forward to provide timely and critical guidance." 

Guidelines for QTc monitoring during treatment

The antimalarial drugs chloroquine and hydroxychloroquine, as well as the HIV drugs lopinavir and ritonavir, all carry a known or possible risk of drug-induced ventricular arrhythmias and sudden cardiac death. Prior to starting treatment with these medications, it is important to get a baseline ECG to be able to measure changes. This starting point measurement could be from a standard 12-lead ECG, telemetry or a smartphone-enabled mobile ECG device. On Monday, March 20, the Food and Drug Administration (FDA) granted emergency approval of AliveCor's Kardia 6L mobile ECG device as the only FDA-approved mobile device for QTc monitoring with COVID-19. 

The mobile device's ability to remotely provide the patient's heart rhythm and QTc value does not require an extra ECG technician to take the measurement in person, thus saving increased exposure to COVID-19 and the need for more personal protective equipment. 

Using the algorithm developed by Dr. Ackerman and colleagues, the potential risk of drug-induced arrhythmias can be rated and used to modify treatment accordingly. For example, patients with a baseline QTc value greater than or equal to 500 milliseconds and those that experience an acute QTc reaction with a QTc greater than or equal to 60 milliseconds from baseline after starting treatment with one or more QTc-prolonging drugs are at greatest risk for drug-induced arrhythmias. Simple QTc countermeasures can be implemented for patients with a cautionary "red light" QTc status if the decision is made to proceed with the intended COVID-19 therapies.

Information guides decisions

There are a number of considerations around the use of off-label drugs to treat COVID-19. The drugs may or may not be available in large enough supply to treat a worldwide pandemic, even at the current compassionate use stage of testing. 

It will take careful consideration of COVID-19 patients' circumstances for treating clinicians and patients to decide on the use of drugs or drug combinations that may treat their infection, but which potentially could cause harmful drug-induced side effects. 

Dr. Ackerman says that patients under 40 with mild symptoms and a QTc greater than or equal to 500 milliseconds may choose to avoid treatment altogether, as the arrhythmia risk may far outweigh the risk of developing COVID-19-related acute respiratory distress syndrome. However, in COVID-19 patients with a QTc greater than or equal to 500 milliseconds who have progressively worsening respiratory symptoms or are at greater risk of respiratory complications due to advanced age, immunosuppression or having another high-risk condition, the potential benefit of QTc-prolonging medicines may exceed the arrhythmia risk.

"Importantly, the vast majority of patients ― about 90% ― are going to be QTc cleared with a 'green light go' and can proceed, being at extremely low risk for this side effect," says Dr. Ackerman.

Ultimately, the weighing of risks to benefits depends on whether hydroxychloroquine, with or without azithromycin, is truly an effective treatment against COVID-19. 

"If it is, we hope that this simple QTc surveillance strategy, enabled by innovation and the FDA's emergency approval, will help prevent or at least significantly minimize drug-induced ventricular arrhythmias and sudden cardiac death, particularly if the treatment is widely adopted and used to treat COVID-19," says Dr. Ackerman. 

Other contributors to the study are John Giudicessi, M.D., Ph.D., first author; Peter Noseworthy, M.D.; and Paul Friedman, M.D. ― all Mayo Clinic cardiologists. Drs. Ackerman, Friedman and Noseworthy have a financial interest in AliveCor.

 

 

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2 hours ago, Longhorn_Fan68 said:

I remember reporting not too long ago that the death total in the US was higher than 9/11. Today NYC passed that total alone:
https://apnews.com/6e506c4f105670b8fa8eb5531aadf2c1

Edit: they passed it yesterday. whatever.

Is that two or three days ago? :)

 

did anyone ever ask trump if he took hcq since he has nothing to lose?

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NSIAP:

Quote

Last week, a story about a teenager in Lancaster, California, who appeared to have died from COVID-19 after an urgent care clinic denied him treatment because he didn’t have health insurance, ripped through social media. The story was covered by dozens of news outlets, earned thousands of anguished tweets, and quickly became a symbol of Americans’ fears and the failures of the U.S. health care system.

But the truth, it turns out, is more complicated.

https://time.com/5813731/teen-denied-insurance-coronavirus/

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10 minutes ago, EMAWesome said:

Another update, projected death down another 20,000.  Now down to 60,415.  But Trump has no idea what he's doing.

https://covid19.healthdata.org/united-states-of-america

If you ended up being one of the deaths I would give Trump credit for making Surly a better place.

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"Who could have known" and "no one saw this coming".

US Intelligence.  But we all know what is thought of that.

November.  2019.  For fucks sake.

https://abcnews.go.com/Politics/intelligence-report-warned-coronavirus-crisis-early-november-sources/story?id=70031273&cid=clicksource_4380645_4_heads_hero_live_twopack_hed

 

Quote

As far back as late November, U.S. intelligence officials were warning that a contagion was sweeping through China’s Wuhan region, changing the patterns of life and business and posing a threat to the population, according to four sources briefed on the secret reporting.

Concerns about what is now known to be the novel coronavirus pandemic were detailed in a November intelligence report by the military's National Center for Medical Intelligence (NCMI), according to two officials familiar with the document’s contents.

 

Quote

The report was the result of analysis of wire and computer intercepts, coupled with satellite images. It raised alarms because an out-of-control disease would pose a serious threat to U.S. forces in Asia -- forces that depend on the NCMI’s work. And it paints a picture of an American government that could have ramped up mitigation and containment efforts far earlier to prepare for a crisis poised to come home.

"Analysts concluded it could be a cataclysmic event," one of the sources said of the NCMI’s report. "It was then briefed multiple times to" the Defense Intelligence Agency, the Pentagon’s Joint Staff and the White House.

 

Quote

From that warning in November, the sources described repeated briefings through December for policy-makers and decision-makers across the federal government as well as the National Security Council at the White House. All of that culminated with a detailed explanation of the problem that appeared in the President’s Daily Brief of intelligence matters in early January, the sources said. For something to have appeared in the PDB, it would have had to go through weeks of vetting and analysis, according to people who have worked on presidential briefings in both Republican and Democratic administrations.

"The timeline of the intel side of this may be further back than we’re discussing," the source said of preliminary reports from Wuhan. "But this was definitely being briefed beginning at the end of November as something the military needed to take a posture on."

 

 

Spoiler

The NCMI report was made available widely to people authorized to access intelligence community alerts. Following the report’s release, other intelligence community bulletins began circulating through confidential channels across the government around Thanksgiving, the sources said. Those analyses said China’s leadership knew the epidemic was out of control even as it kept such crucial information from foreign governments and public health agencies.

"It would be a significant alarm that would have been set off by this," former Deputy Assistant Defense Secretary Mick Mulroy, now an ABC News contributor, said of the NCMI report. "And it would have been something that would be followed up by literally every intelligence-collection agency."

Mulroy, who previously served as a senior official at the CIA, said NCMI does serious work that senior government leaders do not ignore.

"Medical intelligence takes into account all source information -- imagery intelligence, human intelligence, signals intelligence," Mulroy said. "Then there’s analysis by people who know those specific areas. So for something like this to have come out, it has been reviewed by experts in the field. They’re taking together what those pieces of information mean and then looking at the potential for an international health crisis."

NCMI is a component of the Pentagon's Defense Intelligence Agency. Together, the agencies’ core responsibilities are to ensure U.S. military forces have the information they need to carry out their missions -- both offensively and defensively. It is a critical priority for the Pentagon to keep American service members healthy on deployments.

Asked about the November warning last Sunday on ABC’s "This Week," Defense Secretary Mark Esper told Chief Anchor George Stephanopoulos, "I can't recall, George. But we have many people who watch this closely. We have the premier infectious disease research institute in America, within the United States Army. So, our people who work these issues directly watch this all the time."

Pressing the secretary, Stephanopoulos asked, "So, you would have known if there was briefed to the National Security Council in December, wouldn't you?"

Esper said, "Yes. I'm not aware of that."

The Pentagon, White House National Security Council and the Office of the Director of National Intelligence each declined to comment Tuesday.

Critics have charged the Trump administration with being flat-footed and late in its response to a pandemic that, after sweeping through Wuhan and then parts of Europe, has now killed more than 12,000 in the U.S.

For his part, President Donald Trump has alternated between taking credit for early action and claiming that the coronavirus was a surprise to him and everyone else. He has repeatedly touted his Jan. 31 decision to restrict air travel with China, but at the same time, he spent weeks telling the public and top administration officials that there was nothing for Americans to fear.

On Jan. 22, for instance, Trump made his first comments about the virus when asked in a CNBC interview, "Are there worries about a pandemic at this point?" The president responded, "No. Not at all. And we have it totally under control. It’s one person coming in from China, and we have it under control. It’s going to be just fine."

As late as Feb. 19, Trump was offering positive reviews for the way China’s leaders had handled the coronavirus.

"I'm confident that they're trying very hard," Trump told an interviewer from Fox 10 in Phoenix. "They're working it -- they built, they built a hospital in seven days, and now they're building another one. I think it's going to work out fine."

It was not until March 13 when Trump declared a national emergency and mobilized the vast resources of the federal government to help public-health agencies deal with the crisis that was poised to crash on to the homeland.

If it were true that America’s spy agencies were caught that off guard, one intelligence official told ABC News, "that would be a massive intel failure on the order of 9/11. But it wasn’t. They had the intelligence."

ABC News contributor John Cohen, who used to oversee intelligence operations at the Department of Homeland Security, said even the best information would be of no use if officials do not act on it.

"When responding to a public health crisis or any other serious security threat, it is critical that our leaders react quickly and take steps to address the threat identified in the intelligence reporting," said Cohen, the former acting undersecretary of DHS. "It’s not surprising to me that the intelligence community detected the outbreak; what is surprising and disappointing is that the White House ignored the clear warning signs, failed to follow established pandemic response protocols and were slow to put in place a government-wide effort to respond to this crisis."

 

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11 hours ago, UDontKnow said:

Still missing the fucking point. It doesn't matter if it's for a penny. It's still unbecoming of the Office of the President and a clear violation of the Hatch Act (something he has violated innumerable times). Donald Trump has a known history of cheating people for less than $99. Furthermore, if it could be worth as little as $99, but then how high could it be? 

Anyone defending Donald Trump at this point is either brain dead or being purposefully obtuse. 

Is this coming from a member of the swarm defending Hunter Biden being paid $600, 000 per year by an Ukranian natural gas company?  Or the millions and millions of "donations" made to the Clinton Foundation before 2016?  The Borg on this forum calling anyone else brain dead is like Keith Richards accusing someone of living an unhealthy lifestyle.

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10 hours ago, JimmyJames said:

Well I already knew he claimed he was rich in here and had a better life than the rest of us, but I didn’t know until this day that he was claiming he was a physician as well. Interesting. If he’s being truthful, which I kind of doubt, that would lower my opinion of physicians quite a bit.

Hes an internet troll hell bent on supporting trump narratives at all costs. He’s simply worthless.

Your epitaph is going to be "Everyone that disagreed with me was a troll."

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16 minutes ago, EMAWesome said:

I think people that call activists scientists don't understand what a scientist is either.

People who actually listen to scientists (note the plural) and comprehend when they say "data trumps models" as they speak during a task force briefing understand that as the data from the home country (America) begins to rise in amount and substance, models can be adjusted which is exactly what 'they' were and are doing. Have you not been listening to what the two leading infectious disease specialists in the country are reporting? These two have been presenting scenarios based on different hypotheticals, but as data came in, every day they have discussed how to interpret that data to the public (each state has different problems/positives), some states have been more successful at distancing, some states have unique demographics.

The WSJ had a very good podcast with Dr. Fauci on their journal series recently. Look it up if you like to listen to podcasts. This issue is discussed as well as steps to get people back out and working until a vaccine is developed.

 

Edit to add--lot of anti-Fauci talk coming from Steve Bannon. He is not a person I would  trust when it comes to infectious diseases and/or agendas.

Edit to add --nor Laura Ingraham who has the qualifications of being an attorney and media personality. She may be exposed to a lot of infectious diseases, but that doesn't make her a scientist nor an expert in the field.

Edited by Mrs Whiggins
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15 minutes ago, EMAWesome said:

I think people that call activists scientists don't understand what a scientist is either.

Quote

Christopher Murray is a researcher in global health and public health at the University of Washington in Seattle and is the institute director of the Institute for Health Metrics and Evaluation (IHME). Beginning in 1990, he has worked on ways to measure the burden of disease and disability around the globe. He has led several projects to gather that data, disease-by-disease, country by country. The aim of these efforts, which involve the work of hundreds of researchers, is to provide data for policy makers around the world to allocate healthcare resources.

He previously served as Director of the Harvard Initiative for Global Health and as Executive Director of the Evidence and Information for Policy Cluster at the World Health Organization. He graduated from Harvard University in 1984 and was a Rhodes Scholar, attending Oxford University, where he earned a DPhil in International Health Economics.[1] In 1988, he returned to Harvard, where he specialized in internal medicine and earned a Medical Doctorate. Since, he has worked on measurement of health and health outcomes. He was a part of the Disease Control Priorities Project. From 2005-2007, Murray was director of the Harvard Center for Population and Development Studies.[citation needed]

In 2007, he moved from Harvard to the University of Washington to head the Institute for Health Metrics and Evaluation with the help of former Mexican Secretary of Health, Julio Frenk, who serves as Chair of the Board of Directors.[2] At the institute, Murray's work has included studying adult and child mortality, costs of various health interventions, and continuing work with colleagues at Harvard, the WHO and elsewhere on projects that conduct research and mine data to improve public health....

 

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13 minutes ago, DefinitelyNotHollywoodColt said:

“They did a great job!”

- Bizarro Sack of Shit

Isn't it great that you (JS) are posting a video account by a 'newsclipping' company that is owned by a man who was the executive producer for Laura Ingraham and would create a cut video ad with a particular bias for a client? I'm thinking I disagree, I also think it is odd that the owner of the company lives in Spain when President Trump was explicit that product needs to be made in America.

What a faux patriot you are.

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19 minutes ago, Johnny Sack said:

Yeah, now do the same one where they were given confidential briefings in January that said the disease was more dangerous than we were being told. Oh wait, you can't do it. They weren't given that information. Trump was. I wonder if that would have changed things. . .

P.S. You'll note that there are almost no dates in that video. I can't imagine why that would be (oh yeah, it would give context). 

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4 minutes ago, Francisco 2.0 said:

I'm assuming our President will come out this afternoon and call this fake news.

 

 

 

Sounds like they did a follow up with an ECG and a risk was detected and stopped the trial but I couldn't tell if that was for all or for one patient. Many French are smokers, but I don't know if that was accounted.

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1 minute ago, F250 said:

Do you not realize that you your words present you as one of the dumbest fuckers on all of Surly? This has nothing to do with politics there are conservative posters here that are clearly intelligent. You are not one of those posters. I really don't mean this as an insult but based on your opinions,  you appear to be really fucking stupid.

 

Es verdad, amigo.

38 minutes ago, EMAWesome said:

Your epitaph is going to be "Everyone that disagreed with me was a troll."

But then he busts out with this.

So, I am going to conclude that EMAW really isn't that dumb.  It's just what happens when you try to defend the indefensible.

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Complicated as in 100% bullshit.  As in the kid was insured and no urgent care clinic was involved.

This sort of shit is infuriating because it simply bolsters cognitive dissonance. “Fake news!” Sometimes is true. Here it’s more indicative that it so hard to undo the damage of a mistaken report.
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1 hour ago, EMAWesome said:

Another update, projected death down another 20,000.  Now down to 60,415.  But Trump has no idea what he's doing.

https://covid19.healthdata.org/united-states-of-america

Thank God Harris and Travis county made the unpopular decision early on of canceling the Houston Rodeo and SXSW 

those unpopular decisions saved lives 

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24 minutes ago, Dahobbs said:

Yeah, now do the same one where they were given confidential briefings in January that said the disease was more dangerous than we were being told. Oh wait, you can't do it. They weren't given that information. Trump was. I wonder if that would have changed things. . .

P.S. You'll note that there are almost no dates in that video. I can't imagine why that would be (oh yeah, it would give context). 

If Trump comes out and drives hysteria in the US during the impeachment process, he'd get castrated for trying to create an event to avoid impeachment -- especially when at the time WHO was saying there was no person to person transmission.  Fauci and the CDC were telling everyone in late February the risk to Americans was low.  Isn't Adam Schiff chair of the intelligence oversight committee with access to intelligence?  Maybe had he spent time on the intelligence role instead of an impeachment that did not even allege a crime and had zero chance of removing the president, things would have been different.

If we get out of this with 60,000 deaths as is now modeled, that is a huge win for the country.  And there will be a lot of credit going around to federal, state and local governments.

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1 minute ago, Johnny Sack said:

If Trump comes out and drives hysteria in the US during the impeachment process, he'd get castrated for trying to create an event to avoid impeachment -- especially when at the time WHO was saying there was no person to person transmission.  Fauci and the CDC were telling everyone in late February the risk to Americans was low.  Isn't Adam Schiff chair of the intelligence oversight committee with access to intelligence?  Maybe had he spent time on the intelligence role instead of an impeachment that did not even allege a crime and had zero chance of removing the president, things would have been different.

If we get out of this with 60,000 deaths as is now modeled, that is a huge win for the country.  And there will be a lot of credit going around to federal, state and local governments.

BWHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHA

What a maroon. 

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26 minutes ago, Mrs Whiggins said:

Sounds like they did a follow up with an ECG and a risk was detected and stopped the trial but I couldn't tell if that was for all or for one patient. Many French are smokers, but I don't know if that was accounted.

Obesity is as significant of a risk factor as smoking is for heart and blood pressure issues. 

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13 minutes ago, DDD Dad said:


This sort of shit is infuriating because it simply bolsters cognitive dissonance. “Fake news!” Sometimes is true. Here it’s more indicative that it so hard to undo the damage of a mistaken report.

I laughed out loud at this part of that time article.

So the story that had gone viral simply wasn’t true: the teenager did not go to an urgent care clinic and he wasn’t uninsured. But one reason the story exploded on social media is that it felt emblematic of a broader, societal failing because it easily could have been true.

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5 minutes ago, Johnny Sack said:

If Trump comes out and drives hysteria in the US during the impeachment process, he'd get castrated for trying to create an event to avoid impeachment -- especially when at the time WHO was saying there was no person to person transmission.  Fauci and the CDC were telling everyone in late February the risk to Americans was low.  Isn't Adam Schiff chair of the intelligence oversight committee with access to intelligence?  Maybe had he spent time on the intelligence role instead of an impeachment that did not even allege a crime and had zero chance of removing the president, things would have been different.

If we get out of this with 60,000 deaths as is now modeled, that is a huge win for the country.  And there will be a lot of credit going around to federal, state and local governments.

If only there was some pre-existing pandemic response team that could have non-politically sounded the alarm bells. But if trump disbanded such a team years ago it's totally not his fault, right?

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3 minutes ago, Dahobbs said:

BWHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHAHA

What a maroon. 

Trump will never get credit from the TDS deranged lunatics on this board.  But the majority of Americans will consider it a huge win if the current model projection of 60,000 deaths comes to fruition.

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3 minutes ago, Anastasis said:

I laughed out loud at this part of that time article.

So the story that had gone viral simply wasn’t true: the teenager did not go to an urgent care clinic and he wasn’t uninsured. But one reason the story exploded on social media is that it felt emblematic of a broader, societal failing because it easily could have been true.

That's where I stopped reading. 

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