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Texas Jeff

By Texas Jeff
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Dontshootrude
Dontshootrude

Reading the last couple pages of this thread, I can't help but jump in here.  I'm a molecular biologist.  I'm happy to verify with the mods, just PM me so I don't dox myself.  I have not read most of

EE2B
EE2B

This was posted by an ER doc from a local hospital: I have been mostly silent on the COVID surge but I feel it’s a duty and responsibility for healthcare professionals to report what we are seeing an

Somnio
Somnio

You're a fascist who wishes death and suffering upon people.  You're why genocide has happened throughout history.  I've seen your vile posts before.  You need help.  Seriously, I'll swallow my pride

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shadetree

shadetree 66

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Posted

The booster discussed is officially only for Pfizer right now, correct? I haven’t seen any official directives on a monderna booster, but maybe I missed that.
I have seen moderna has studied a booster that is half the regular dose. So people getting moderna boosters now, are they getting the full third dose? Getting that booster without any official guidance/recommendations from any of the federal agencies?

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Anastasis

Anastasis 23498

Posted
Posted (edited)
1 minute ago, shadetree said:

The booster discussed is officially only for Pfizer right now, correct? I haven’t seen any official directives on a monderna booster, but maybe I missed that.
I have seen moderna has studied a booster that is half the regular dose. So people getting moderna boosters now, are they getting the full third dose? Getting that booster without any official guidance/recommendations from any of the federal agencies?

The broader set of recommendations being discussed right now is for PFE, correct.  No guidance on MRNA yet. That being said, the previous guidance for immunocompromised related to both PFE and MRNA.  And yes, the people boosting MRNA right now are getting the elite level dosing, MRNA testing half dose for boosters. 

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Satoshi

Satoshi 129

Posted
Posted
49 minutes ago, pearlandhorn said:

So what was the advisory panel for?

 

30 minutes ago, Liquor and Poker said:

Advice

Pretty much. Which was disregarded/overruled by a political appointee. My impression is that is pretty rare although others here will know better than me. It’s unfortunate because this decision likely leads to mandates for potentially millions of people without much evidence to justify it. 

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Satoshi

Satoshi 129

Posted
Posted
1 minute ago, kevwun said:

Keep slinging that misinformation GRUHorn.

It’s not misinformation to say there is little evidence showing benefit as it relates to improvement in outcomes, especially in younger people. Especially as the protection against severe illness and death appears to be intact.
 

If you’re a 25 year old nurse that has had Covid and has had 2 shots you will likely now be mandated to get a booster in several jurisdictions. Is that justified? We don’t know the risk/benefit for these types of people. I hope it all goes smoothly. 

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Foosters

Foosters 17918

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You have made hundreds of posts on this website over the past 18 months with false information and anti-vax propaganda. You have consistently downplayed the virus and have encouraged people to ignore medical advice under the guise of "just asking questions." You can get fucked. 

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kevwun

kevwun 15943

Posted
Posted (edited)

Do you think the bullshit you've posted on the internet throughout the pandemic has directly led to someone's death?  You've had hundreds of posts of lies and I'm sure this website isn't the only place you infect.  I bet you have killed someone.  There's a special place in hell for scum like you.

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Chewbacca

Chewbacca 7793

Posted
Posted
30 minutes ago, Satoshi said:

It’s not misinformation to say there is little evidence showing benefit as it relates to improvement in outcomes, especially in younger people. Especially as the protection against severe illness and death appears to be intact.
 

If you’re a 25 year old nurse that has had Covid and has had 2 shots you will likely now be mandated to get a booster in several jurisdictions. Is that justified? We don’t know the risk/benefit for these types of people. I hope it all goes smoothly. 

We don't know the risk?  What fucking risk?  Well over 6 billion shots have been administered.  If there were risks, we would know about them by now.

 

Get fucked with that bullshit.

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Guest

Guest

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Posted

Long time listener (from the old site... and the even older site), first time caller.

Moderna second dose in mid-April.
Texas Cares study last month with 1,600. 
COVID as of Sunday after kid brought it home from school.

He was fine in a day. I had a pretty rough 3-4 days. Don't "feel" sick now, but still have a lingering cough and sense of smell is 100% gone. Wife had the same vaccine schedule and had about 1,200 on Texas Cares and still testing negative.

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Guest

Guest

Posted
Posted
37 minutes ago, Deej said:

Russian Reaction GIF

Yeah with the kid going to school, we just assumed it would eventually hit our house despite us trying to be careful for the past 18 months. But really thought the 1600 antibody count meant that I wouldn't get it when it did make the rounds.

I will say that the first at-home test we used on the kid showed bright positive within just a minute. Mine showed so faint that I wasn't even sure it was positive until confirmed with PCR. Maybe the brightness of the positive on the antigen test has to do with the amount of virus? Doesn't matter. That faint line turned into a decent case that knocked me down. Kid coughed for about two minutes and had a slight fever. Now he is bouncing off the walls.

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DaysOff

DaysOff 8002

Posted
Posted
It’s not misinformation to say there is little evidence showing benefit as it relates to improvement in outcomes, especially in younger people. Especially as the protection against severe illness and death appears to be intact.
 
If you’re a 25 year old nurse that has had Covid and has had 2 shots you will likely now be mandated to get a booster in several jurisdictions. Is that justified? We don’t know the risk/benefit for these types of people. I hope it all goes smoothly. 

Jesus, you really don't want people to get this free shot that has statistically zero risk. Why are you a piece of shit? Are you Greg Abbott?
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Satoshi

Satoshi 129

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Posted
6 hours ago, Chewbacca said:

We don't know the risk?  What fucking risk?  Well over 6 billion shots have been administered.  If there were risks, we would know about them by now.

 

Get fucked with that bullshit.

 

1 hour ago, DaysOff said:


Jesus, you really don't want people to get this free shot that has statistically zero risk. Why are you a piece of shit? Are you Greg Abbott?

This from the Lancet lays out why boosters aren’t justified without further testing. It’s signed by multiple prominent people including the two FDA officials that are resigning in protest after devoting their careers to advancing vaccines. This isn’t a fringe position. 
 

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02046-8/fulltext

 

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Bookman

Bookman 4722

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Posted

Can't wait to get my mom the booster shot. All these unvaxxed assholes have let covid linger. This is a crisis yet so many Americans have their fingers up their ass.

It's really no wonder a failed businessman got elected President of the United States. C students fucking vote.

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Guest Lobo

Guest Lobo

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Posted
6 minutes ago, Bookman said:

Can't wait to get my mom the booster shot. All these unvaxxed assholes have let covid linger. This is a crisis yet so many Americans have their fingers up their ass.

It's really no wonder a failed businessman got elected President of the United States. C students fucking vote.

Dude, Cloak Room is that way ----------->

You can brand water, vodka, wine, steaks, casinos, airlines, USFL teams, board games, magazines, hotels, condo towers, universities, chocolates, menswear, and even vitamins.  But it never occurred to anyone to brand vaccinations.  All anybody needed to do was, "The Moderna Vaccine...Brought to you by So-and-So." 6 billion shots in arms worldwide in the last year...and the most brilliant branding expert on Earth failed to seize on the opportunity.  It would have saved countless lives and made him hundreds of millions.  How did they not grab onto this chance?  

Oh yeah.  Right, right, right.  Wouldn't have been ethical.  My bad.

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Captainant

Captainant 27970

Posted
Posted
23 minutes ago, Herbie Hancock said:

Satoshi is a shit stain and should be crowdsourced, but y’all gotta lay off the fucking hyperbole. And even if it isn’t hyperbole and somehow posts on the internet by a known idiot led to someone’s demise, well then strike up the band and play one for Darwin.

Well it's more that he's on his fourth sock at this point. The community keeps telling him he's not welcome to post his disinformation here but he is on a mission

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SizzleChest

SizzleChest 8291

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On 9/24/2021 at 8:22 PM, Satoshi said:

 

This from the Lancet lays out why boosters aren’t justified without further testing. It’s signed by multiple prominent people including the two FDA officials that are resigning in protest after devoting their careers to advancing vaccines. This isn’t a fringe position. 
 

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02046-8/fulltext

 

You've been on this site for the last 18 months advocating anti-vaxx / let's suffer and die our way out of this pandemic / 'wait, it really isn't a pandemic,  just a bad flu' / Hydrochloroquine and Ivermectin will fix this because vaccines are just corporations exercising greed positions.

Now, you are here, of course, supporting a position where there happen to be legit scientific disagreements about vaxx boosting and how we shouldn't be harming people without however-the-fuck-long-it-takes-to-get-more-data while the virus mutates and keeps coming back.  Not to mention defending FDA officials who left their positions because the administration is listening to Fauci and others instead of them?  Oh, the horror.

You're just a snappy little bitch on their second (maybe third or fourth) handle because the community has repeatedly shown you they're sick of your shit.  But you are a disinformation warrior and will not be denied.  You are an adult male chiropractor probably with a shitty Youtube channel popping wheelies on a tricycle.

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Bevo

Bevo 13633

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Posted
2 hours ago, SizzleChest said:

Now, you are here, of course, supporting a position where there happen to be legit scientific disagreements about vaxx boosting and how we shouldn't be harming people without however-the-fuck-long-it-takes-to-get-more-data while the virus mutates and keeps coming back.  Not to mention defending FDA officials who left their positions because the administration is listening to Fauci and others instead of them?  Oh, the horror.

I don't know anything about the poster, but the article is good.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02046-8/fulltext

 

Although the benefits of primary COVID-19 vaccination clearly outweigh the risks, there could be risks if boosters are widely introduced too soon, or too frequently, especially with vaccines that can have immune-mediated side-effects (such as myocarditis, which is more common after the second dose of some mRNA vaccines,or Guillain-Barre syndrome, which has been associated with adenovirus-vectored COVID-19 vaccines. If unnecessary boosting causes significant adverse reactions, there could be implications for vaccine acceptance that go beyond COVID-19 vaccines. Thus, widespread boosting should be undertaken only if there is clear evidence that it is appropriate.

Current evidence does not, therefore, appear to show a need for boosting in the general population, in which efficacy against severe disease remains high. Even if humoral immunity appears to wane, reductions in neutralising antibody titre do not necessarily predict reductions in vaccine efficacy over time, and reductions in vaccine efficacy against mild disease do not necessarily predict reductions in the (typically higher) efficacy against severe disease. This effect could be because protection against severe disease is mediated not only by antibody responses, which might be relatively short lived for some vaccines, but also by memory responses and cell-mediated immunity, which are generally longer lived.The ability of vaccines that present the antigens of earlier phases of the pandemic (rather than variant-specific antigens) to elicit humoral immune responses against currently circulating variants indicates that these variants have not yet evolved to the point at which they are likely to escape the memory immune responses induced by those vaccines. Even without any changes in vaccine efficacy, increasing success in delivering vaccines to large populations will inevitably lead to increasing numbers of breakthrough cases, especially if vaccination leads to behavioural changes in vaccinees.

To date, none of these studies has provided credible evidence of substantially declining protection against severe disease, even when there appear to be declines over time in vaccine efficacy against symptomatic disease.

 

Conclusion:

If boosters (whether expressing original or variant antigens) are ultimately to be used, there will be a need to identify specific circumstances in which the direct and indirect benefits of doing so are, on balance, clearly beneficial. Additional research could help to define such circumstances. Furthermore, given the robust booster responses reported for some vaccines, adequate booster responses might be achievable at lower doses, potentially with reduced safety concerns. Given the data gaps, any wide deployment of boosters should be accompanied by a plan to gather reliable data about how well they are working and how safe they are. Their effectiveness and safety could, in some populations, be assessed most reliably during deployment via extremely large-scale randomisation,17 preferably of individuals rather than of groups.
 
Thus, any decisions about the need for boosting or timing of boosting should be based on careful analyses of adequately controlled clinical or epidemiological data, or both, indicating a persistent and meaningful reduction in severe disease, with a benefit–risk evaluation that considers the number of severe cases that boosting would be expected to prevent, along with evidence about whether a specific boosting regimen is likely to be safe and effective against currently circulating variants. As more information becomes available, it may first provide evidence that boosting is needed in some subpopulations. However, these high-stakes decisions should be based on peer-reviewed and publicly available data and robust international scientific discussion.
 
The vaccines that are currently available are safe, effective, and save lives. The limited supply of these vaccines will save the most lives if made available to people who are at appreciable risk of serious disease and have not yet received any vaccine. Even if some gain can ultimately be obtained from boosting, it will not outweigh the benefits of providing initial protection to the unvaccinated. If vaccines are deployed where they would do the most good, they could hasten the end of the pandemic by inhibiting further evolution of variants. Indeed, WHO has called for a moratorium on boosting until the benefits of primary vaccination have been made available to more people around the world.18 This is a compelling issue, particularly as the currently available evidence does not show the need for widespread use of booster vaccination in populations that have received an effective primary vaccination regimen.
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Guest Lobo

Guest Lobo

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Posted

It's truly the first Catch-22 I've seen in my lifetime.  You need more vaccinated adults to get some kinda herd immunity.  But we're literally getting to watch hundreds of thousands of stupid people die and improve overall society.  I guess "addition by subtraction"? 

If I'm being insensitive, I'll apologize when this is all over.  

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dcbc

dcbc 14568

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Posted
27 minutes ago, Lobo said:

It's truly the first Catch-22 I've seen in my lifetime.  You need more vaccinated adults to get some kinda herd immunity.  But we're literally getting to watch hundreds of thousands of stupid people die and improve overall society.  I guess "addition by subtraction"? 

If I'm being insensitive, I'll apologize when this is all over.  

Well, as the antivaxxers succumb, the percentage of vaccinated goes up.

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Dontshootrude

Dontshootrude 374

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9 hours ago, Bevo said:

I don't know anything about the poster, but the article is good.

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02046-8/fulltext

 

Although the benefits of primary COVID-19 vaccination clearly outweigh the risks, there could be risks if boosters are widely introduced too soon, or too frequently, especially with vaccines that can have immune-mediated side-effects (such as myocarditis, which is more common after the second dose of some mRNA vaccines,or Guillain-Barre syndrome, which has been associated with adenovirus-vectored COVID-19 vaccines. If unnecessary boosting causes significant adverse reactions, there could be implications for vaccine acceptance that go beyond COVID-19 vaccines. Thus, widespread boosting should be undertaken only if there is clear evidence that it is appropriate.

Current evidence does not, therefore, appear to show a need for boosting in the general population, in which efficacy against severe disease remains high. Even if humoral immunity appears to wane, reductions in neutralising antibody titre do not necessarily predict reductions in vaccine efficacy over time, and reductions in vaccine efficacy against mild disease do not necessarily predict reductions in the (typically higher) efficacy against severe disease. This effect could be because protection against severe disease is mediated not only by antibody responses, which might be relatively short lived for some vaccines, but also by memory responses and cell-mediated immunity, which are generally longer lived.The ability of vaccines that present the antigens of earlier phases of the pandemic (rather than variant-specific antigens) to elicit humoral immune responses against currently circulating variants indicates that these variants have not yet evolved to the point at which they are likely to escape the memory immune responses induced by those vaccines. Even without any changes in vaccine efficacy, increasing success in delivering vaccines to large populations will inevitably lead to increasing numbers of breakthrough cases, especially if vaccination leads to behavioural changes in vaccinees.

To date, none of these studies has provided credible evidence of substantially declining protection against severe disease, even when there appear to be declines over time in vaccine efficacy against symptomatic disease.

 

Conclusion:

If boosters (whether expressing original or variant antigens) are ultimately to be used, there will be a need to identify specific circumstances in which the direct and indirect benefits of doing so are, on balance, clearly beneficial. Additional research could help to define such circumstances. Furthermore, given the robust booster responses reported for some vaccines, adequate booster responses might be achievable at lower doses, potentially with reduced safety concerns. Given the data gaps, any wide deployment of boosters should be accompanied by a plan to gather reliable data about how well they are working and how safe they are. Their effectiveness and safety could, in some populations, be assessed most reliably during deployment via extremely large-scale randomisation,17 preferably of individuals rather than of groups.
 
Thus, any decisions about the need for boosting or timing of boosting should be based on careful analyses of adequately controlled clinical or epidemiological data, or both, indicating a persistent and meaningful reduction in severe disease, with a benefit–risk evaluation that considers the number of severe cases that boosting would be expected to prevent, along with evidence about whether a specific boosting regimen is likely to be safe and effective against currently circulating variants. As more information becomes available, it may first provide evidence that boosting is needed in some subpopulations. However, these high-stakes decisions should be based on peer-reviewed and publicly available data and robust international scientific discussion.
 
The vaccines that are currently available are safe, effective, and save lives. The limited supply of these vaccines will save the most lives if made available to people who are at appreciable risk of serious disease and have not yet received any vaccine. Even if some gain can ultimately be obtained from boosting, it will not outweigh the benefits of providing initial protection to the unvaccinated. If vaccines are deployed where they would do the most good, they could hasten the end of the pandemic by inhibiting further evolution of variants. Indeed, WHO has called for a moratorium on boosting until the benefits of primary vaccination have been made available to more people around the world.18 This is a compelling issue, particularly as the currently available evidence does not show the need for widespread use of booster vaccination in populations that have received an effective primary vaccination regimen.

That is a good article. This one is pretty good too.

 

https://www.bmj.com/content/374/bmj.n2320

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Al Bundy's Napoleon Hand

Al Bundy's Napoleon Hand 13596

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Posted

Wasn't surprised when I got a notification Friday night from a mutual friend that one of our friends whom I had cut off contact after he went full Evang-MAGA anti-vax had died from Covid. Took it as the second shoe drop. Matter-of-fact. But now as it's processing, I'm just getting angrier and angrier. 

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Bevo

Bevo 13633

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Posted
12 hours ago, MissingInAction said:

Is the WHO taking into account the millions of stupid cunts not getting g even one shot here in the great ole Merica?

No, more of what the articles are saying is that without knowing when someone can benefit from a booster, the world would be better off shipping the vaccine to a third world country. The more people in the world who get vaccinated (at least with the first series), the lower the chance of breakthrough infections and the lower the chance of new, more infectious variants. And the articles aren't saying that boosters are bad. They are saying that there could be potential side-effects like carditis so more data is necessary to determine booster dosage and timing for subpopulations.

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Guest Lobo

Guest Lobo

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Posted

Probably fighting each other over supplies in a horse stable somewhere.

Only think I know is 35% of this country would have found another way to kill themselves and take some innocents out with them.  

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OneOfTheOutOfFocusGuys

OneOfTheOutOfFocusGuys 2117

Posted
Posted
6 hours ago, Pato del Muerto said:

Anyone else given a minute of thought as to where we’d be right now if delta had happened and there was no vaccine prophylaxis?  Pretty grim, I’d say. 

i remember some back of the envelope math when this all started saying we might ultimately end up with a 2% death rate.  6MM in the US.

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