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Tell me about Ozempic (Wegovy, etc)


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I’m down about 33 pounds in 12 weeks. For me the worst side effect has been insomnia: I fall asleep fine but tend to wake up around 2 or 3 and have trouble getting back to sleep. It’s worst right after the injection and gets better as the week goes on.

Welcome to perimenopause! How are the hot flashes?
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On 12/3/2024 at 4:39 PM, tigol said:


Welcome to perimenopause! How are the hot flashes?

No hot flashes but down 46 lbs in 21 weeks. I’m no longer obese, just overweight. I still have a gut but I’m into smaller clothes (no more XL) and Ive retired a couple of belts. Even my eyeglasses don’t fit any more. 2 more lbs and I’ll be under 200 for the first time in decades. 

At 5’ 10” and 175 lbs I’ll be considered a healthy weight so that’s the goal, which I could possibly reach by March. I need to start building back some muscle and strength, I can tell I’ve lost some, but that’s typical for any weight loss journey. 

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On 6/7/2024 at 11:36 PM, Viper said:

Then how did 30% of Americans genetics change in the 80s and 90s?

As a semi-professional medical scientist, I'd speculate that the amount of shit ingredients and substitutes put into processed food and beverages has increased at a similar trend to obesity. Perhaps some people's genetics are minimally effected, while others store excess calories. Some of these ingredients have neurological effects, such as craving/addiction and behavioral disorders in children. Most European countries ban these ingredients or slap warning labels all over it, which could relate to Europeans not being as obese as Americans. Also, the poorer you are, the more cheap food you buy, which has more of the crap ingredients. Switching all Americans to fresh meat, produce, dairy, and baked goods and eliminating processed sweets, pasta, sauces, etc. would probably result in a significant decline in obesity without watching calories.

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21 hours ago, Hate said:

So how does this impact your alcohol intake? Any side effects when drinking copious amounts of bourbon?

I’d suggest staying away from anything with carbonation or sugar, and take it easy on your first outing. Even at a low dose I get quite a bit of heartburn, and all that makes it worse for me. Accidentally double dosed myself once. That was a bad 4-5 days. 

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On 12/5/2024 at 4:04 PM, Hate said:

So how does this impact your alcohol intake? Any side effects when drinking copious amounts of bourbon?

In my past experience, drinking alcohol turns off Ozempic's ability to make me want to stop eating.  

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On 12/5/2024 at 2:55 PM, Murfdogg21 said:

As a semi-professional medical scientist, I'd speculate that the amount of shit ingredients and substitutes put into processed food and beverages has increased at a similar trend to obesity. Perhaps some people's genetics are minimally effected, while others store excess calories. Some of these ingredients have neurological effects, such as craving/addiction and behavioral disorders in children. Most European countries ban these ingredients or slap warning labels all over it, which could relate to Europeans not being as obese as Americans. Also, the poorer you are, the more cheap food you buy, which has more of the crap ingredients. Switching all Americans to fresh meat, produce, dairy, and baked goods and eliminating processed sweets, pasta, sauces, etc. would probably result in a significant decline in obesity without watching calories.


All of a sudden I have a craving for Hostess Donuts.

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On 12/5/2024 at 3:55 PM, Murfdogg21 said:

As a semi-professional medical scientist, I'd speculate that the amount of shit ingredients and substitutes put into processed food and beverages has increased at a similar trend to obesity. Perhaps some people's genetics are minimally affected, while others store excess calories. Some of these ingredients have neurological effects, such as craving/addiction and behavioral disorders in children. Most European countries ban these ingredients or slap warning labels all over it, which could relate to Europeans not being as obese as Americans. Also, the poorer you are, the more cheap food you buy, which has more of the crap ingredients. Switching all Americans to fresh meat, produce, dairy, and baked goods and eliminating processed sweets, pasta, sauces, etc. would probably result in a significant decline in obesity without watching calories.

I lost 30 lbs in 10 weeks on an anti-inflammatory diet - lean protein, whole grain, fruits, vegetables, nuts, seeds, some dairy, eggs, salt, pepper and healthy oils - everything not on the list was strictly off limits. Total added sugar per day was 3-4 grams max. If my family would join me I could stay on that diet, the flavors exploded after about 4 weeks. Didn’t watch calories, ate as much as I wanted. 

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4 minutes ago, troph said:

I lost 30 lbs in 10 weeks on an anti-inflammatory diet - lean protein, whole grain, fruits, vegetables, nuts, seeds, some dairy, eggs, salt, pepper and healthy oils - everything not on the list was strictly off limits. Total added sugar per day was 3-4 grams max. If my family would join me I could stay on that diet, the flavors exploded after about 4 weeks. Didn’t watch calories, ate as much as I wanted. 

 

I'm doing a starvation diet for the heck of it - I don't really need to lose weight but I'm kind of nostalgic for the days when I had a 6 pack and no body fat. I'm transitioning towards retirement and have a sandwich and sun chips for lunch and go work out on the way home and then just have some nuts and fruit for dinner. I'm real hungry in the morning, but in the evening I'm pretty good. Unfortunately, I think I have only lost about 7lbs in a month and a half and I'll probably gain it back in a weekend, but at least I'm putting in the effort. The interesting thing is that up until I started the diet, I ate a whole lot more but now I don't miss it. It feels like my stomach has shrunk.

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11 hours ago, Bevo said:

 

I'm doing a starvation diet for the heck of it - I don't really need to lose weight but I'm kind of nostalgic for the days when I had a 6 pack and no body fat. I'm transitioning towards retirement and have a sandwich and sun chips for lunch and go work out on the way home and then just have some nuts and fruit for dinner. I'm real hungry in the morning, but in the evening I'm pretty good. Unfortunately, I think I have only lost about 7lbs in a month and a half and I'll probably gain it back in a weekend, but at least I'm putting in the effort. The interesting thing is that up until I started the diet, I ate a whole lot more but now I don't miss it. It feels like my stomach has shrunk.

Starvation diets will mess up your system based on what I’ve read. Better to just course correct on your diet. There is some mixed evidence for fasting for 2-3 days once a month, but straight up starvation isn’t a great idea. For most if you follow a diet like I outlined you (1) can’t really over eat bc is fiber filled, high volume low calorie foods, and (2) absence of inflammatory foods lets your body heal and rest from these foods that create a chronic state of inflammation which triggers weight retention.  

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13 hours ago, troph said:

I lost 30 lbs in 10 weeks on an anti-inflammatory diet - lean protein, whole grain, fruits, vegetables, nuts, seeds, some dairy, eggs, salt, pepper and healthy oils - everything not on the list was strictly off limits. Total added sugar per day was 3-4 grams max. If my family would join me I could stay on that diet, the flavors exploded after about 4 weeks. Didn’t watch calories, ate as much as I wanted. 

So basically just eat with common sense. I think….. I can do this one?  

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26 minutes ago, Kennythetiger said:

So basically just eat with common sense. I think….. I can do this one?  

I think it's a lot more than that. only lean proteins, whole grains, nuts, seeds, eggs, limited dairy, fruits and vegetables.

common sense eating generally means under 50g (absurd USDA guideline), under 20g of added sugar and generally avoiding animal based saturated fats. that's skipping ice cream, potato chips, crackers, bread, pizza, burgers (buns), tex-mex, cheap pasta, no butter, limited cheeses, choosing wisely at restaurants, etc. That's not too hard to do. 20-50g of added sugar and generally avoiding animal based saturated fats isn't getting any of us to very healthy status in our 50s - 80s ... our genetics might protect us some, exercise too, but if you want to be lean and fit as you age it's sleep, exercise, diet as described, relationships, and hope you've got the good genes. 

5 grams or less of added sugar, eat 2 cups of cheerios with no added sugar milk or no added sugar oat milk and you're at 4 grams for the day.  added sugar is everywhere except the produce section, nuts, seeds, eggs and unprepared raw meats, fish and poultry.  whole grains, you have to scrutinize the label. go to the cereal aisle. you'll find maybe 3-4 selections in the entire aisle that have under 5g of added sugar in a small serving size. it's insane.

if your household isn't on board with an anti-inflammatory diet, it's really hard to accomplish. simply put - in the US, an under 5g per day of added sugar and virtually no animal based saturated fat diet is ridiculously difficult - but it is doable.

all of that said, my 5 months on this diet was incredible. I never felt more healthy in my life, all the while I was still pretty ill with covid but recovering. I would stay on this diet if I could convince my family, but I can't. So I'm going to try and manage through it.  this week is a strict week as I added 5 pounds the last month.

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5 hours ago, troph said:

Starvation diets will mess up your system based on what I’ve read. Better to just course correct on your diet. There is some mixed evidence for fasting for 2-3 days once a month, but straight up starvation isn’t a great idea. For most if you follow a diet like I outlined you (1) can’t really over eat bc is fiber filled, high volume low calorie foods, and (2) absence of inflammatory foods lets your body heal and rest from these foods that create a chronic state of inflammation which triggers weight retention.  

Yeah, I’m not talking about true starvation, more like eating lunch and then having nuts and fruit when I get home. I say starvation simply because I’m use to eating a whole lot more.

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17 hours ago, troph said:

I lost 30 lbs in 10 weeks on an anti-inflammatory diet - lean protein, whole grain, fruits, vegetables, nuts, seeds, some dairy, eggs, salt, pepper and healthy oils - everything not on the list was strictly off limits. Total added sugar per day was 3-4 grams max. If my family would join me I could stay on that diet, the flavors exploded after about 4 weeks. Didn’t watch calories, ate as much as I wanted. 

What kind of meals would you have, how often, and what were the portions if you don't mind me inquiring?

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1 hour ago, chainsaw said:

What kind of meals would you have, how often, and what were the portions if you don't mind me inquiring?

I didn't have the energy to really learn to cook on this diet, I was really, really sick when I was in the thick of it..... but here's some typical meals:

breakfast:
- smoothie - spinach, organic peanut butter (no sugar added), dates, peaches, bananas, oat milk.
- yogurt with berries - plain yogurt, strawberries, blueberries, sometimes grapes, nuts (pecans, walnuts, cashews), seeds (pepitas, sunflower)
- small bowl of muesli with oat milk (look at the ingredients, there are low added sugar brands out there)
- eggs and leftover veggies the night before (often potatoes - resistant starches (chilled and reheated potatoes are one of them) are great for gut health)

lunch:
- left overs from dinner the night before
- eggs if not for breakfast
- raw veggies - cucumbers, carrots, radishes, celery
- fruit - watermelon, apples, pears, peaches, cherries

favorite snacks:
- fresh okra sliced and baked with salt, pepper, olive oil and dash of cayenne (I'd eat as much as I could until I wasn't hungry)
- popcorn - organic nothing added except healthy oil and salt
- that smoothie for breakfast if I didn't have it for breakfast
- spoonful of almond butter.

dinner:
- chicken breast pan sauteed, broccoli, poatoes, green beans all boiled or steamed then pan sauteed with garlic, oil, salt/pepper
- pork tenderloin roasted in the oven, sweet potatoes and squash (cooked the same as the veggies above)
- fresh fish pan sauteed with asparagus and carrots and rice (veggies cooked the same way as above)
- big garden salad with all the veggies I could throw in there - micro greens too! make a olive oil based vinaigrette.
- 4 oz beef filet usually in a steak salad for a cheat. filet because it's lean.

desert:
- WATERMELON!!!
- GRAPES!!!
- sometimes that yogurt bowl above.
- I would sneak a spoonful of honey peanut butter from HEB (2g of added sugar) if I just had to have a sugar hit.
- maybe another smoothie but with the honey peanut butter instead of regular.

late night snack:
- if hungry and my added sugar was low enough and I didn't have cereal that morning I might sneak a bowl of museli or cheerios with oat milk.

I later added mootopia HEB branded milk which has less sugar and I used 2% so less fat too instead of oat milk.  too much milk would throw me off so I would not do cereal, smoothie and cereal again in one day.

my dinners were large portions. I'd cook as much broccoli and potatoes as I could eat along with my sensible cut of protein. I'd eat a whole sweet potato (peeled and cut up). 2-3 eggs at a time. lots of olive oil. the absolute key is to watch dairy/animal saturated fat and added sugar. you really have to have your added sugar at near zero - I'd say even actual zero for a few weeks. the carbs in my diet were plentiful and they are harmless even good for you until you have too much added sugar, at that point it all seems to go rancid and weight gain is inevitable. but with virtually zero added sugar, the natural carbs become a non issue.  I devoured potatoes and fruit, lost weight without trying.

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1 minute ago, troph said:

I didn't have the energy to really learn to cook on this diet, I was really, really sick when I was in the thick of it..... but here's some typical meals:

breakfast:
- smoothie - spinach, organic peanut butter (no sugar added), dates, peaches, bananas, oat milk.
- yogurt with berries - plain yogurt, strawberries, blueberries, sometimes grapes, nuts (pecans, walnuts, cashews), seeds (pepitas, sunflower)
- small bowl of muesli with oat milk (look at the ingredients, there are low added sugar brands out there)
- eggs and leftover veggies the night before (often potatoes - resistant starches (chilled and reheated potatoes are one of them) are great for gut health)

lunch:
- left overs from dinner the night before
- eggs if not for breakfast
- raw veggies - cucumbers, carrots, radishes, celery
- fruit - watermelon, apples, pears, peaches, cherries

favorite snacks:
- fresh okra sliced and baked with salt, pepper, olive oil and dash of cayenne
- popcorn - organic nothing added except healthy oil and salt
- that smoothie for breakfast if I didn't have it for breakfast
- spoonful of almond butter.

dinner:
- chicken breast pan sauteed, broccoli, poatoes, green beans all boiled or steamed then pan sauteed with garlic, oil, salt/pepper
- pork tenderloin roasted in the oven, sweet potatoes and squash (cooked the same as the veggies above)
- fresh fish pan sauteed with asparagus and carrots and rice (veggies cooked the same way as above)
- big garden salad with all the veggies I could throw in there - micro greens too! make a olive oil based vinaigrette.
- 4 oz beef filet usually in a steak salad for a cheat. filet because it's lean.

desert:
- WATERMELON!!!
- sometimes that yogurt bowl above.
- I would sneak a spoonful of honey peanut butter from HEB (2g of added sugar)
- maybe another smoothie but with the honey peanut butter instead of regular.

late night snack:
- if hungry and my added sugar was low enough and I didn't have cereal that morning I might sneak a bowl of museli or cheerios with oat milk.

I later added mootopia HEB branded milk which has less sugar and I used 2% so less fat too instead of oat milk.  too much milk would throw me off so I would not do cereal, smoothie and cereal again in one day.

the absolute key is to watch dairy/animal saturated fat and added sugar. the carbs in my diet were plentiful and they are harmless even good for you until you have too much added sugar, at that point it all seems to go rancid and weight gain is inevitable. but with virtually zero added sugar, the natural carbs become a non issue.  I devoured potatoes and fruit, lost weight without trying.

Thank you!

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47 minutes ago, chainsaw said:

Are there any spices you can't use? I saw salt, pepper, cayenne listed and presumably okay

well, I was focused on not harming a recovery (and so I added low histamine to my diet which kicked out a lot of spices), but I think most spices are going to be fine and are anti-inflammatory. so you could actually get really creative with the cooking especially if your household would buy into it. I was alone in that diet so it didn't work as well.

on a low histamine diet even garlic is off limits, avocados, tomatoes, a number of fruits - all citrus, beans, legumes, the list goes on and I don't want to drudge that up, so what meals I described above is more restrictive than an anti-inflammatory diet. what is exactly on point though is the base description of lean proteins, nuts, seeds, limited dairy, eggs, fruits, good oils, vegetables and whole grains. That's exactly anti-inflammatory and our bodies (I think) crave this diet.

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19 minutes ago, troph said:

well, I was focused on not harming a recovery (and so I added low histamine to my diet which kicked out a lot of spices), but I think most spices are going to be fine and are anti-inflammatory. so you could actually get really creative with the cooking especially if your household would buy into it. I was alone in that diet so it didn't work as well.

on a low histamine diet even garlic is off limits, avocados, tomatoes, a number of fruits - all citrus, beans, legumes, the list goes on and I don't want to drudge that up, so what meals I described above is more restrictive than an anti-inflammatory diet. what is exactly on point though is the base description of lean proteins, nuts, seeds, limited dairy, eggs, fruits, good oils, vegetables and whole grains. That's exactly anti-inflammatory and our bodies (I think) crave this diet.

as far as portioning goes, is there a X grams per Y lbs body weight type of rule?

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Just now, chainsaw said:

as far as portioning goes, is there a X grams per Y lbs body weight type of rule?

these foods are so fiber rich and the exact opposite of calorie dense I don't think you really have to worry about it. I would not go crazy on meat and dairy especially at first. but as long as you are heavy on the vegetables at dinner a 6-8 ounce piece of chicken isn't going to mess you up. and you will be full on cooked broccoli or sweet potatoes long before you max out on calories. I had heaping plates of sweet potatoes and green beans and I was just too full to keep going and then I had my resistant starches for the next day. 

If I was going to do this diet again for weight loss, I would first focus on eliminating the bad stuff and only eating the good stuff. I would not limit portions at all. I would go all in on it and eat as much as you want - BUT I would make for damn sure you were at zero added sugars and no animal saturated fat. Don't cheat with that honey peanut butter at HEB, don't put a smidge of butter in your oatmeal, don't pinch some brown sugar in there. don't. do it.

4 weeks in of no added sugar and no animal fat, then take a look and see what's going on. In theory you could be eating too much but again once your body is off the shit, it has a lot of room for good carbs and a lot of room for good fat.

If I recall correctly I also added yogurt later, I definitely added milk later, so limited dairy for sure at the beginning.

on meat - I'd not go past one chicken breast for dinner, or on pork tenderloin I would have 5 or 6 slices. Fish an HEB filet even if 1.5 servings is fine. I would not eat those meat servings twice a day. 

whole grains does not mean whole grain pasta or whole grain bread, I mean oatmeal, museli stuff like that.

strict is the key.

a month in you might find like I did that I actually craved certain healthy foods. my go to's were roasted okra, watermelon, grapes and potatoes. god I would just devour potatoes.

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24 minutes ago, chainsaw said:

Thanks. I'm less interested in weight loss than I am in feeling reduced inflammation and the secondary effects that could have

I'll add that I did some calorie counting and holy shit a heaping plate of vegetables even with the oil and the lean protein for dinner, 800 calories is the max I could get to. 

as for the health side of it? a lot of it you can't see but my blood work was absolutely perfect and my blood pressure was under 120/80. the rest of the benefits don't show up until later in life when you are still kicking it healthy wise.

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43 minutes ago, troph said:

I'll add that I did some calorie counting and holy shit a heaping plate of vegetables even with the oil and the lean protein for dinner, 800 calories is the max I could get to. 

as for the health side of it? a lot of it you can't see but my blood work was absolutely perfect and my blood pressure was under 120/80. the rest of the benefits don't show up until later in life when you are still kicking it healthy wise.

And of course no alcohol on its own does a few good things as well

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On 1/27/2025 at 5:13 PM, troph said:

I'll add that I did some calorie counting and holy shit a heaping plate of vegetables even with the oil and the lean protein for dinner, 800 calories is the max I could get to. 

as for the health side of it? a lot of it you can't see but my blood work was absolutely perfect and my blood pressure was under 120/80. the rest of the benefits don't show up until later in life when you are still kicking it healthy wise.

While not as strict as your discipline, I have been eating only fresh foods the last few days. Last night a friend of mine gave me a handful of thin mint Girl Scout cookies. I have been up since 3 this morning. My body doesn’t feel good. I think you might be on to something. 

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It's not until you try to commit to one of these diets that you realize how frequently life brings you junk food, candy, and other "bad" foods. So fucking many bachelor parties, birthdays, family gatherings, work functions, game watch parties, the list goes on. Life's much easier when you aren't having to think about what goes in your mouth. That's probably why ozempic has been such a success. If what they say is true, it takes the mental burden away by neutering one's desire for food

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1 hour ago, chainsaw said:

It's not until you try to commit to one of these diets that you realize how frequently life brings you junk food, candy, and other "bad" foods. So fucking many bachelor parties, birthdays, family gatherings, work functions, game watch parties, the list goes on. Life's much easier when you aren't having to think about what goes in your mouth. That's probably why ozempic has been such a success. If what they say is true, it takes the mental burden away by neutering one's desire for food

Pretty much. I can walk by a bowl of Doritos at a party and just not be interested. 
 

You do have to make sure you’re getting enough protein, exercising, and hydrating like crazy. The constipation can be really bad. 

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I’ve lost 22 pounds since September.  All the doctors and clinics we send our clients to constantly send us cakes and donuts and cookies and fudge brownies to the point I gained 20 pounds after working there a year and a half.   I started on Wegovy (sp) and noticed I could walk by the gourmet muffins and not grab one, and instead grab a banana and have that for lunch.

One nice benefit is that I’ve lost my desire to have a second third or fourth drink.   I don’t feel sick, I just no longer have the desire. And I’m sure part of it is I finally decided I wanted to lose weight and get in better shape, and so I don’t know how to separate the psychological - with me intentionally shopping to make sure I have a lot more salads and vegetables to steam for dinner - or the longer digestion period and reduction of my hunger in general from the drug

I have noticed my chest freezer is getting full, because instead of finishing a big plate or having seconds I now consider them leftovers and throw them in the freezer.  The freezer is getting annoyed as I don’t have room for anything.  All in all I’m happy I’m doing it.

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17 hours ago, Kennythetiger said:

While not as strict as your discipline, I have been eating only fresh foods the last few days. Last night a friend of mine gave me a handful of thin mint Girl Scout cookies. I have been up since 3 this morning. My body doesn’t feel good. I think you might be on to something. 

I wouldn’t give me any credit. Before the onslaught of fake food, you didn’t have to call it anti inflammatory it was just a healthy diet. Research is really pretty clear, added sugar which includes processed carbs is a disaster for your health.  If you cut those out, get exercise, sleep well, have good relationships, then you’re way ahead of the game. I’d add focusing on brain health too since you might make it to your 90s with those other factors.  It’s straight up science, it’s rather indisputable at this point. 

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2 minutes ago, chainsaw said:

The answer is greed

I meant more about are all of the drugs coming out of shortage, will insurance cover name brand? Saw an article that suggests a lot of folks will lose access bc it’s not going to be covered. Is that a legit concern?

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7 hours ago, troph said:

What’s the deal with the FDA pulling the shortage designation on these drugs which would eliminate the the cheaper alternatives ?  

Saw an article where they were talking about side effects from what these drugs are being compounded with. How true that is I couldn't say. 

As far as greed, I can understand the companies wanting to recoup those development costs and drugs that failed to pan out, but hasn't ozempic been out for awhile to treat diabetes? Is it still not past the patent stage yet or do they get a new one to treat weight loss?

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9 hours ago, troph said:

I wouldn’t give me any credit. Before the onslaught of fake food, you didn’t have to call it anti inflammatory it was just a healthy diet. Research is really pretty clear, added sugar which includes processed carbs is a disaster for your health.  If you cut those out, get exercise, sleep well, have good relationships, then you’re way ahead of the game. I’d add focusing on brain health too since you might make it to your 90s with those other factors.  It’s straight up science, it’s rather indisputable at this point. 

Sometimes all it takes is one person speaking up. 

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