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Psychedelic Mushrooms on FDA Fast Track

F250

By F250
in Daily Texan

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F250

F250 28823

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Posted (edited)

I've been reading about hallucinogens being used to treat depression, anxiety and PTSD. It will be interesting to see how the final approval looks. I imagine it wouldn't be people selling a plastic baggy of mushrooms.

 

https://www.rollingstone.com/culture/culture-news/psilocybin-legal-therapy-mdma-753946/

 

 

 

Edited by F250
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Anastasis

Anastasis 23484

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These are HUGE effect sizes in a treatment resistant population. Still a ways to go, only phase II. But a promising signal. 

 

https://www.statnews.com/2021/11/09/largest-psilocybin-trial-finds-psychedelic-effective-treating-serious-depression/

https://ir.compasspathways.com/news-releases/news-release-details/compass-pathways-announces-positive-topline-results

 

Eagerly awaited results of the largest-ever study of psilocybin were announced Tuesday, with Compass Pathways revealing the psychedelic drug was highly efficacious as a therapy for treatment-resistant depression. Still, the company’s stock price dropped 16.4% by the close of trading, perhaps because of safety concerns among investors.

The Phase 2b study is the largest randomized, controlled, double-blind trial of psilocybin, the psychedelic compound in magic mushrooms. The company said it found that patients who were given the highest dose, 25 milligrams, had a significant decrease in depressive symptoms compared to those given 1 milligram, which is such a low dose it functions as a placebo.

Overall, 29.1% of patients in the highest-dose group were in remission three weeks after treatment, compared to 7.6% of those in the control group, and more than a quarter of the patients in the 25-milligram arm were still in remission three months after treatment.

Those who received the highest dose also experienced an average reduction on a measure of clinical depression (the Montgomery-Asberg Depression Rating Scale) that was 6.6 points greater than those who took 1 milligram. Other patients were given a 10-milligram dose, but there was not a statistically significant impact for those patients compared with the 1-milligram arm.

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WhatTheBuck

WhatTheBuck 28798

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3 hours ago, Deej said:

Made the mistake once of brewing tea with a quarter ounce of mushrooms. Just two of us. Best day of my life. 

Doesn’t sound like a mistake to me.

A friend and I split a quarter once. And they were really potent. We just ate them. That was a great night.

My most vivid memory was listening to the Beatles Past Masters Vol. II album. Sitting on opposite ends of the couch, I had my eyes closed and during Let it Be I realized I was crying, tears streaming down my face. It was just so beautiful. I thought it was curious that I should have that response so I turned to my friend to show him. And there he sat, eyes closed, with tears streaming down his face. It was wild. 

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Homercles

Homercles 10206

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Most I recall taking was 7g, which I do not recommend…but I wanted to push it, as tripping had become a 2-3x per month experience at that time given how easy they are to grow (this was 20 years ago) and having nothing better to do.  Then again I had control over set/setting, roommates knew to leave me alone, and a few Valium if needed.  
 

Typical dose for a Friday night was an eighth…never understand how people could be so chill like ‘eat a handful of caps and stems’…motherfucker I want to make damn sure how much I’m taking and not get surprised with a monster, unwanted crawl through The Other Side.  
 

Glad that there are some people with the brains and drive to explore medicinal use, and having it schedule 1 is regarded.   Same with MDMA for PTSD.  My only problems with either were being unable to sleep afterwards, and inevitable jacked up serotonin for a day that comes with the territory.  Too many children of Reefer Madness in power and still hold certain chemicals in fearful reverence.  

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Deej

Deej 76933

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11 hours ago, WhatTheBuck said:

Doesn’t sound like a mistake to me.

A friend and I split a quarter once. And they were really potent. We just ate them. That was a great night.

My most vivid memory was listening to the Beatles Past Masters Vol. II album. Sitting on opposite ends of the couch, I had my eyes closed and during Let it Be I realized I was crying, tears streaming down my face. It was just so beautiful. I thought it was curious that I should have that response so I turned to my friend to show him. And there he sat, eyes closed, with tears streaming down his face. It was wild. 

It felt like a mistake for the first 30 minutes after drinking that tea. I thought the little alien thing was going to burst out of my stomach. Then, *poof*...and it was all good. 

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